Lake Erie Center for the Great Lakes and Human Health

伊利湖五大湖与人类健康中心

• 批准号: 10427310
• 负责人: George S Bullerjahn
• 金额: $ 30.39万
• 依托单位: BOWLING GREEN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10427310
• 关键词: Address; Area; Attention; Boat; Chronic; Coast Guard; Collaborations; Communities; Complement; Core Facility; Data; Detection; Development; Environment; Environmental Health; Environmental Science; Event; Faculty; Forestry; Fostering; Fresh Water; Funding Opportunities; Goals; Grant; Habitats; Health; Human; Human Resources; Institution; Interdisciplinary Study; International; Investments; Journals; Laboratory Research; Lead; Leadership; Michigan; Monitor; National Oceanic and Atmospheric Administration; North Carolina; Nutrient; Oceans; Ohio; Policies; Productivity; Publications; Recording of previous events; Research; Research Activity; Research Project Grants; Risk; Role; Science; Services; Shapes; Solid; Structure; System; Tennessee; Toxic effect; Toxin; Universities; Vision; Water; Water Supply; Work; anthropogenesis; biomedical scientist; citizen science; climate change; climate impact; college; community engaged research; community engagement; drinking water; foodborne; harmful algal blooms; improved; innovation; inter-institutional; lipidomics; medical schools; metabolomics; metatranscriptomics; multidisciplinary; operation; programs; research facility; response; symposium; technology development; tool; water quality

OVERALL: SUMMARY The Lake Erie Center for Fresh Waters and Human Health at Bowling Green State University (BGSU) seeks five years of support from the Centers for Oceans and Human Health 3: Impacts of Climate Change on Oceans and Great Lakes program (COHH3) (P01). Support is requested for research, facilities operations and community engagement activities that build on academic and agency partnerships that have developed in the wake of the 2014 Toledo Water Crisis. Locating this COHH3 at BGSU reflects a leading role assumed by BGSU personnel studying the chronic cyanobacterial Harmful Algal Blooms (cHABs) of Lake Erie and complements significant ongoing investments made by BGSU. A COHH3 Lake Erie Center for Fresh Waters and Human Health will promote inter-institution collaboration to generate cutting-edge research toward identifying environmental drivers of cHABs and the effect of climate change on the proliferation and toxicity of bloom events and their impact on human health. This Center will shape the national research agenda; promote community engagement; and leverage strong institutional and agency support. Presently aligned as a multi-disciplinary research area in Lake Erie and Watershed Studies at BGSU, this effort seeks to formalize relations with affiliates active in cHAB research elsewhere. BGSU personnel were pressed into action to help lead the scientific response to the 2014 Toledo Water Crisis following contamination of Toledo's water supply by cHAB toxins. With the crisis still unfolding, BGSU coordinated with Center affiliates to study the bloom event and communicate issues related to the crisis to a concerned public. With the water crisis still receiving national attention, BGSU assumed the lead in organizing an international symposium held at BGSU in April 2015 which provided a forum to share ideas related to cHABs and their mitigation. BGSU also worked closely with federal legislators in the aftermath of the crisis to address issues of water quality in Lake Erie leading to the passing of H.R. 212, The Drinking Water Protection Act. The proposed research activities of Center affiliates are consistent with the goals and structure outlined for COHH3 with projects addressing human health effects of cHABs in the framework of climate change, toxin discovery and toxicity, enhanced monitoring/forecasting and community engagement. This application pursues four overarching goals: 1) Create an integrated, multi-disciplinary Center facilitating collaboration between biomedical scientists and limnologists; 2) Heighten the scientific influence, innovation, and productivity of Center affiliates; 3) Support development of Center affiliates including junior faculty; and 4) Energize cHAB science with new data and research tools. These goals will be accomplished through integration of projects and by supporting four complementary cores: Administrative, Research, Community Engagement, and Facilities. Center affiliates are providing national leadership, and our vision is to continue to foster an environment of innovation and collaboration that yields high impact research on cutting-edge issues related to climate change and its effect on cHABs and their impact on human health.

总体：摘要 鲍灵格林州立大学（BGSU）的伊利湖新鲜水域和人类健康中心寻求五个 海洋与人类健康中心的多年支持3：气候变化对海洋和海洋的影响 大湖计划（COHH3）（P01）。请求支持研究，设施运营和社区 建立在学术和代理机构伙伴关系之后的参与活动 2014托莱多水危机。在BGSU上找到此COHH3反映了BGSU人员承担的主要作用 研究伊利湖的慢性蓝细菌有害藻类花朵（CHABS），并补充了重要 BGSU进行的正在进行的投资。 COHH3伊利湖新鲜水域和人类健康中心将 促进机构间的合作，以产生尖端的研究以识别环境驱动力 CHAB和气候变化对Bloom事件的增殖和毒性的影响及其对 人类健康。该中心将塑造国家研究议程；促进社区参与；和 利用强大的机构和代理支持。目前以湖泊的多学科研究区域对齐 BGSU的伊利和流域研究，这项努力旨在正式与活跃于CHAB的关联公司的关系形式化 在其他地方进行研究。 BGSU人员采取行动，以帮助领导2014年的科学回应 托莱多水危机污染了Chab毒素的托莱多供水。危机仍然 展开，BGSU与中心分支机构协调研究Bloom事件并交流与 对关心的公众危机。随着水危机仍引起全国关注，BGSU取得了领先 2015年4月在BGSU举行的国际研讨会上，该研讨会提供了一个论坛来分享想法 与CHAB及其缓解有关。 BGSU还与联邦立法者紧密合作。 解决伊利湖水质问题的危机，导致H.R. 212逝世，饮用水 保护法。中心分支机构的拟议研究活动与目标和结构一致 针对COHH3概述了针对气候变化框架中CHAB的人类健康影响的项目， 毒素发现和毒性，增强监测/预测和社区参与。此应用程序 追求四个总体目标：1）创建一个综合的，多学科的中心促进合作 在生物医学科学家和林木学家之间； 2）提高科学影响力，创新和生产力 中心分支机构； 3）支持包括初级教师在内的中心分支机构的发展； 4）chab充满活力 具有新数据和研究工具的科学。这些目标将通过集成项目和 通过支持四个互补的核心：行政，研究，社区参与和设施。 中心分支机构正在提供国家领导，我们的愿景是继续营造一个环境 对与气候变化有关的尖端问题产生高影响研究的创新与协作 及其对CHAB的影响及其对人类健康的影响。

项目成果

Insight Into the Molecular Mechanisms for Microcystin Biodegradation in Lake Erie and Lake Taihu

• DOI: 10.3389/fmicb.2019.02741
• 发表时间: 2019-12-10
• 期刊: FRONTIERS IN MICROBIOLOGY
• 影响因子: 5.2
• 作者: Krausfeldt, Lauren E.;Steffen, Morgan M.;Wilhelm, Steven W.
• 通讯作者: Wilhelm, Steven W.

Metagenome-Assembled Genome of a Pseudanabaena sp. from a Crimson Cyanobacterial Bloom in Lake Salubria, New York, USA.

• DOI: 10.1128/mra.00494-22
• 发表时间: 2022-09-15
• 期刊: MICROBIOLOGY RESOURCE ANNOUNCEMENTS
• 影响因子: 0.8
• 作者: Martin, Robbie M.;Gann, Eric R.;Truchon, Alex R.;Boyer, Gregory L.;Wilhelm, Steven W.
• 通讯作者: Wilhelm, Steven W.

The “Neglected Viruses” of Taihu: Abundant Transcripts for Viruses Infecting Eukaryotes and Their Potential Role in Phytoplankton Succession

• DOI: 10.3389/fmicb.2020.00338
• 发表时间: 2020-03
• 期刊: Frontiers in Microbiology
• 影响因子: 5.2
• 作者: H. Pound;Eric R. Gann;Xiangming Tang;Lauren E. Krausfeldt;M. Huff;M. Staton;D. Talmy;S. Wilhelm

Limnological Differences in a Two-Basin Lake Help to Explain the Occurrence of Anatoxin-a, Paralytic Shellfish Poisoning Toxins, and Microcystins.

• DOI: 10.3390/toxins12090559
• 发表时间: 2020-08-30
• 期刊: Toxins
• 影响因子: 4.2
• 作者: Smith ZJ;Conroe DE;Schulz KL;Boyer GL
• 通讯作者: Boyer GL

Cool temperature acclimation in toxigenic Microcystis aeruginosa PCC 7806 and its non-toxigenic mutant.

产毒铜绿微囊藻 PCC 7806 及其非产毒突变体的低温驯化。

• DOI: 10.1101/2023.08.28.555099
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Stark,GwendolynF;Martin,RobbieM;Smith,LauraE;Wei,Bofan;Hellweger,FerdiL;Bullerjahn,GeorgeS;McKay,RMichaelL;Boyer,GregoryL;Wilhelm,StevenW
• 通讯作者: Wilhelm,StevenW