Longitudinal Study of Health and Ageing in Kenya (LOSHAK)

肯尼亚健康与老龄化纵向研究 (LOSHAK)

• 批准号: 10427945
• 负责人: Joshua Robert Ehrlich
• 金额: $ 33.86万
• 依托单位: AGA KHAN UNIVERSITY (KENYA)
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-15 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10427945
• 关键词: Accounting; Address; Adopted; Adult; Africa; Africa South of the Sahara; African; Age; Aging; Air Pollution; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Area; Climate; Cognition; Cohort Studies; Collection; Community Health; Complex; Computer Assisted; Computer software; Consumption; Country; Data; Data Collection; Demographic Transitions; Development; Droughts; Economics; Elderly; Enrollment; Environmental Exposure; Epidemiologic Monitoring; Epidemiology; Family; Floods; Future; Goals; Health; Health and Retirement Study; Heat Waves; Home; Human Resources; Income; Individual; Infrastructure; Intervention; Interview; Kenya; Knowledge; Longitudinal Studies; Measurement; Measures; Mental Health; Michigan; Modeling; Participant; Personal Satisfaction; Persons; Physiological; Population; Population Growth; Population Study; Probability Samples; Procedures; Process; Protocols documentation; Research; Research Support; Resources; Risk Factors; Sampling; Sister; South Africa; Strategic Planning; Surveys; System; Training; Universities; Work; age group; aged; aging population; blood-based biomarker; climate change; climate impact; cognitive testing; cohort; computer infrastructure; computerized data processing; data harmonization; data sharing; design; disability; experience; follow-up; health economics; infrastructure development; instrument; low and middle-income countries; molecular marker; pilot test; population based; recruit; success; trend

The proposed project aims to build the infrastructure needed to successfully field the Longitudinal Study of Health and Ageing in Kenya (LOSHAK), a population-based cohort study of adults age ≥45 years in Kenya. This will be a new study in the Health and Retirement Study (HRS) network of harmonized studies on aging. Key focus areas of LOSHAK will include Alzheimer’s disease and related dementias (ADRD), mental health, the health and economic impacts of climate change and air pollution, and factors influencing late-life economic well-being. Kenya currently has a relatively young population, but is poised to experience very rapid aging of its population over the next 30 years. Accordingly, it is vitally important to begin studying both population-level trends, as well as individual aging trajectories in order to characterize risk factors for health, disability, and well-being in the Kenyan context. Importantly, there is a major gap in population-level data on aging in Sub-Saharan Africa, and LOSHAK will be only the second study in the HRS Network from the region. In order to carry out the proposed infrastructure development aims, we will leverage our study team’s ongoing epidemiologic surveillance platform, the Kaloleni/Rabai Community Health and Demographic Surveillance System (KRHDSS) in coastal Kenya, which includes more than 14,000 individuals age ≥45 years. In this application we propose the following aims: 1) to adapt and validate existing HRS network measures and new survey and data collection protocols (molecular biomarkers, physiological measures) within the KRHDSS; 2) To design Wave 1 of LOSHAK, including a sampling strategy to draw a regionally-representative probability sample; and 3) To develop a long-term strategic plan for expansion towards a nationally-representative panel study of aging in Kenya for Wave 2 of LOSHAK. The KRHDSS platform will enable us to efficiently recruit and enroll participants and will contribute to our success carrying out these aims. Throughout the infrastructure development process, we will work closely with the HRS and the HRS Sister Studies Network in order to maximize comparability with the measures and processes (e.g., training in HRS interview administration, use of computer-assisted personal interviewing software, data processing, etc) used in other HRS network studies. Thus, LOSHAK will ultimately provide key population-based and comprehensive measures on health and economic well-being from mid- to late-life. These data will be harmonized in order to enable cross-national comparisons with high-income and other low- and middle-income countries, thereby expanding opportunities to understand health and aging in a global context.

拟议的项目旨在建立成功实施健康纵向研究所需的基础设施 肯尼亚（Loshak）的衰老，这是一项基于人群的队列研究，对肯尼亚的成年人≥45岁。这将是 健康和退休研究（HRS）的一项新研究，统一研究。关键重点领域 Loshak将包括阿尔茨海默氏病和相关痴呆症（ADRD），心理健康，健康和 气候变化和空气污染的经济影响，以及因素影响晚期经济福祉。 肯尼亚目前有相对年轻的人口，但被毒死以经历其人口的迅速衰老 在接下来的30年中。据认为，开始研究这两个人口级趋势至关重要 作为个体衰老轨迹，以表征健康，残疾和幸福感的风险因素 肯尼亚语境。重要的是，撒哈拉以南非洲衰老的人口水平数据存在很大的差距，以及 Loshak将只是该地区HRS网络中的第二项研究。为了执行提议 基础设施发展的目的是，我们将利用研究团队正在进行的流行病学监视平台， 肯尼亚海岸 其中包括14,000多名年龄≥45岁的人。在此应用程序中，我们提出以下目的： 1）适应和验证现有的HRS网络测量结果以及新的调查和数据收集协议（分子 生物标志物，物理措施）KRHDSS； 2）设计Loshak的第1波，包括抽样 绘制区域代表性样本的策略； 3）制定长期战略计划 扩展了肯尼亚衰老的全国代表性小组研究。这 KRHDSS平台将使我们能够有效地招募和注册参与者，并为我们的成功做出贡献 执行这些目标。通过基础设施开发过程，我们将与人力资源管理 以及HRS姊妹研究网络，以最大程度地与措施和过程进行比较（例如， HRS访谈管理中的培训，使用计算机辅助的个人访谈软件，数据 处理等其他人力资源网络研究中使用的处理等。那，Loshak最终将提供基于人群的关键 以及从中期到后期的健康和经济福祉的全面措施。这些数据将是 为了与高收入和其他低收入和中等收入进行跨国比较 国家，从而扩大了在全球环境中了解健康和衰老的机会。