Longitudinal study of sleep deficiency mechanisms among Filipino migrants

菲律宾移民睡眠不足机制的纵向研究

基本信息

批准号：
10418716
负责人：
Gilbert Gee
金额：
$ 27.1万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-23 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10418716
关键词：
Accidental Injury Acculturation Adult Affect African American population Alaska American Area Asian Americans Asian population Belief Biological Markers Blood Buffers Cardiometabolic Disease Centers for Disease Control and Prevention (U.S.)Circadian Rhythms Cities Custom Data Data Collection Diabetes Mellitus Diet Discrimination Economics Emigrant Environment Filipino Filipino American Health Healthy People 2020 Heart Diseases Heterogeneity High Prevalence Immigrant Insulin Resistance Intervention Studies Interview Lead Learning Light Longitudinal Studies Measures Mediating Mediator of activation protein Migrant Minority Groups National Health Interview Survey Noise Obesity Occupational Participant Patient Self-Report Personal Satisfaction Persons Philippines Physical activity Play Population Public Health Qualitative Research Reporting Research Resources Risk Sleep Sleep Deprivation Sleep Disorders Sleep disturbances Social support Spottings Stimulus Stress Subgroup Sunlight Texas Time Translational Research Travel United States National Institutes of Health Variant actigraphy biopsychosocial disparity reduction environmental stressor health goals high risk improved informant insight longitudinal design mortality novel occupational stressor poor sleep psychosocial psychosocial stressors residence rumination shift work sleep onset sleep pattern sleep quality social capital stressor

项目摘要

ABSTRACT Sleep deficiency is a major public health concern. The Centers for Disease Control and Prevention shows that about 20% of American adults have insufficient sleep. Short sleep duration and irregular sleep timing is related to increased risk for health problems ranging from obesity to diabetes to earlier mortality, as well as other problems such increased unintentional injuries and decreased ability to concentrate. Per Healthy People 2020, understanding the burden sleep deficiencies among minority populations is an important public health goal. Filipino Americans are a significant population from which to study sleep because they have relatively high rates of diabetes, obesity, and heart disease, and preliminary studies have suggested that they also have shorter sleep duration compared with African Americans and Whites. A major unanswered question relates to the mechanisms that may drive shorter sleep duration and irregular sleep timing. We hypothesize that stress plays a key role, and that several important mechanisms mediate the association between stressors and sleep disparities. These mechanisms include rumination, diet, physical activity, disrupted routines, and environmental stimuli, such as noise and light. The present study builds on an ongoing 3-year longitudinal study of Filipino American immigrants titled, Health of Philippine Emigrants Study (HoPES; R01HD083574). HoPES is currently in its first year and collects detailed information regarding stressors, diet, physical activity, anthropometrics and biomarkers obtained from dried blood spots. This application seeks to add objective measures of sleep activity via actigraphy, and comprehensive sleep quality questions. We will also study the effects of sunlight variability as another mechanism that may disrupt circadian rhythms. Our study will integrate a biopsychosocial framework from which to longitudinally study sleep patterns of Filipinos (n=832) across the U.S. over 4 years of new data collection. We will also conduct key-informant interviews and re-interviews with 60 participants in 6 cities across the nation to understand the cultural mechanisms that may affect sleep disturbances.

抽象的睡眠不足是一个主要的公共卫生问题。疾病控制和预防中心表明约20％的美国成年人睡眠不足。短睡眠时间和不规则的睡眠时机相关从肥胖到糖尿病到早期死亡率的健康问题的风险增加，以及其他问题增加了无意的伤害和浓缩能力的降低。在2020年健康的人中了解少数族裔人口中的睡眠不足是一个重要的公共卫生目标。菲律宾美国人是研究睡眠的重要人群，因为他们的人数相对较高糖尿病，肥胖和心脏病的发生率以及初步研究表明，它们也有与非洲裔美国人和白人相比，睡眠持续时间较短。一个主要的未解决的问题与可能促进较短睡眠持续时间和不规则的机制有关睡眠时间。我们假设压力起着关键作用，并且几种重要机制介导压力源与睡眠差异之间的关联。这些机制包括反省，饮食，身体活动，例程和环境刺激，例如噪声和光线。本研究基于对菲律宾美国移民的持续3年纵向研究，名为《健康》菲律宾移民研究（Hopes; R01HD083574）。希望目前已经进入第一年，并收集有关压力源，饮食，体育锻炼，拟人化和生物标志物的详细信息干血点。该应用程序旨在通过艺术学添加客观的睡眠活动衡量，并全面的睡眠质量问题。我们还将研究阳光变异性的影响可能破坏昼夜节律的机制。我们的研究将从在4年的新数据中，纵向研究菲律宾人的睡眠模式（n = 832）收藏。我们还将与6个城市的60名参与者进行密钥信息面试和重新审视在全国范围内了解可能影响睡眠障碍的文化机制。