Training Program on Genetic Variation and Human Phenotypes

遗传变异和人类表型培训计划

• 批准号: 10420390
• 负责人: Nancy J Cox
• 金额: $ 31.22万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10420390
• 关键词: Genetic Variation; Human; Phenotype; Training Programs

Project Summary: The Vanderbilt Training Program in Genetic Variation and Human Phenotypes supports predoctoral students in human genetics. We request funding for 8 predoctoral students, funded for two years. The mission of this program is to prepare these students for a successful career in human genetics in an academic, industrial, or public service capacity. We prepare our students beginning with skills-focused classroom instruction and transitioning to experienced- based learning through research and active collaboration with more experienced mentors. Students are regularly exposed to leaders in human genetics research through their collaborations, research seminars, and attendance at national and international meetings. This training program has enjoyed broad success, with our students achieving excellent productivity (mean 5.1, range 2-11, publications during graduate school by recently funded students). Student excitement for human genetics training has rapidly increased, demonstrated by a 3-fold increase in the number of students entering the Vanderbilt Human Genetics (HGEN) PhD program over the past 5 years. Much of that increased excitement has grown from the unprecedented data available now to students. Previously, it could take years of career advancement to assemble even a single large-scale cohort of a single phenotype. However, with the advent of large biobanks with clinical data, cohorts can now be assembled relatively quickly by graduate students with the proper training, which our program provides. The Vanderbilt HGEN program has been at the forefront of training graduate students in this new type of research. With Vanderbilt’s own large- scale biobank (BioVU), and now the Data and Research Center for the NIH “All of Us” program located in the Vanderbilt University Medical Center, our graduate students have been getting both hands-on and formal didactic training in this new and groundbreaking type of research. With the establishment in 2015 of the Vanderbilt Genetics Institute, Vanderbilt has committed substantial resources for recruitment of faculty in genetics and genomics and additional investment in genotyping of biobank subjects. Our graduate students are well-rounded biologists, with most matriculating through the Interdisciplinary Graduate Program (IGP) at Vanderbilt and the rest from the Quantitative & Chemical Biology Program (QCB). They conduct research in an amazing variety of topics and publish as graduate students in the top scientific journals. Their education is clearly empowering them, as the students themselves are major designers of their own collaborative research within Vanderbilt, and they rightly feel that they are not just benefitting from the excitement in the field of human genetics today but are also driving it.

项目摘要：遗传变异和人类表型的范德比尔特培训计划 支持人类遗传学中的专业学生。我们要求为8位学生提供资金， 资助两年。该计划的任务是为这些学生做好准备 在学术，工业或公共服务能力的人类遗传学职业。我们准备我们的 从以技能为重点的课堂教学和过渡到经验的学生 - 通过研究和与经验丰富的导师的积极合作进行基于学习。 学生经常通过人类遗传学研究领导者 合作，研究中心以及参加国家和国际会议的出席。这 培训计划取得了广泛的成功，我们的学生取得了出色的产品 （平均5.1，范围2-11，研究生院期间的出版物由最近资助的学生提供）。学生 人类遗传学训练的兴奋迅速增加，这是3倍的增长证明 进入范德比尔特人遗传学（HGEN）博士学位计划的学生人数 过去5年。这种增加的兴奋已经从前所未有的数据增长 现在可供学生使用。以前，组装可能需要数年的职业发展 即使是单个表型的一个大型队列。但是，随着大型生物库的冒险 有了临床数据，研究生现在可以相对较快地组装 我们计划提供的适当培训。 Vanderbilt HGE计划一直在 在这项新型研究中，培训研究生的最前沿。与范德比尔特自己的大型 比例生物库（BIOVU），现在是NIH“我们所有人”计划的数据与研究中心 我们的研究生位于范德比尔特大学医学中心 在这项新型和开创性的研究中，动手和正式的教学培训。与 范德比尔特（Vanderbilt）于2015年成立于2015年范德比尔特遗传学研究所 招募遗传学和基因组学教师的资源以及在 生物库受试者的基因分型。我们的研究生是全面的生物学家，大多数 通过范德比尔特的跨学科研究生课程（IGP）和其余的 定量与化学生物学计划（QCB）。他们以惊人的 各种各样的主题，并在高级科学期刊上出版。他们的教育是 显然会增强他们的能力，因为学生自己是自己的主要设计师 范德比尔特（Vanderbilt）的合作研究，他们正确地认为他们不仅受益 当今人类遗传学领域的兴奋，但也在推动它。