Nutrition-specific interventions to improve long-term maternal-child health outcomes

改善长期母婴健康结果的营养针对性干预措施

• 批准号: 10413872
• 负责人: NANCY F KREBS
• 金额: $ 60.66万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-05 至 2023-08-06
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10413872
• 关键词: Address; Americas; Aspirin; Awareness; Cessation of life; Child; Child Health; Child Mortality; Child Nutrition; Clinical Trials; Colorado; Communities; Complementary Feeding; Country; Development; Dose; Exposure to; Follow-Up Studies; Fostering; Funding; Goals; Growth; Growth and Development function; Guatemala; Guatemalan; Health; Health Policy; Human; Infant; Infant Health; Information Dissemination; Institution; Intervention; Intervention Trial; Lead; Leadership; Link; Long-Term Effects; Malnutrition; Maternal Health; Maternal Mortality; Maternal and Child Health; Mentors; Mentorship; Mission; Monitor; Morbidity - disease rate; National Institute of Child Health and Human Development; Observational Study; Outcome; Panama; Participant; Policies; Pregnancy; Productivity; Protocols documentation; Public Health; Publications; Publishing; Registries; Reporting; Research; Research Personnel; Resource-limited setting; Role; Safety; Site; Solid; Study Section; Sustainable Development; Testing; Training Support; Universities; Vulnerable Populations; Woman; Zika Virus; career development; cost effective; data quality; data registry; evidence base; executive function; field study; follow-up; improved; improved functioning; improved outcome; infant morbidity/mortality; meetings; member; mortality; mother nutrition; multidisciplinary; neonatal health; nutrition; offspring; public health intervention; research and development; secondary outcome; skills; support network

PROJECT SUMMARY Meeting the Sustainable Development Goals' 2030 targets for maternal and child morbidity and mortality will require sustained and effective public health interventions for the most vulnerable populations. The broad goal of this application is to continue to participate in all collaborative activities relevant to the mission of the Global Network (GN), which aims to develop and test potential sustainable interventions through collaborative, large- scale, high-impact, multi-site common research protocols. The primary objective of our research unit (RU), which represents a partnership between the University of Colorado and Guatemala, is to develop and implement nutrition-specific interventions to mitigate the effects of pre- and post-natal malnutrition and thereby to improve maternal and infant health outcomes. This objective will be met through the following specific aims: 1) continue to maintain a strong research record and productivity as GN members; 2) continue to foster a progressively stronger research partnership with our colleagues in Guatemala and other GN sites; and 3) continue to develop nutrition-specific interventions as GN common protocols. During the past 5-yr cycle, this RU has built a strong research record, as evidenced by having led two major nutrition-specific common protocols, including the preconception maternal nutrition intervention trial; having strengthened the research capacity in Guatemala; participation in the development and implementation of all GN-initiated common protocols with contribution of a high percentage of cluster/participant numbers to each study; strong productivity in publications (total of 60 with GN co-authors) that report findings of GN supported trials; and having successfully obtained major external funding to support common protocol implementation. Major contributions to the GN by this RU include co-chairing the Protocol Review Sub-committee and the oversight committee for the ongoing Maternal Newborn Health Registry. Successful mentoring and capacity building for the RU is evidenced from invitation by NICHD for the Sr. Foreign Investigator to be site lead for a multi-country observational study of Zika virus exposure during pregnancy. The positive impact of our continued participation in the GN will be to strengthen the multi-disciplinary capacity of the Global Network by identifying nutrition- specific interventions to improve maternal and infant health. Such collaborative research will accelerate the development of evidence-based policies to reduce the global burden of malnutrition and other adverse health outcomes.

项目摘要 实现可持续发展目标的2030年目标目标和儿童发病率和死亡率的目标 为最脆弱的人群需要持续有效的公共卫生干预措施。广泛的目标 该应用程序的内容是继续参与与全球使命相关的所有协作活动 网络（GN），旨在通过协作，大型 - 比例尺，高影响，多站点的共同研究方案。我们研究部门（RU）的主要目标， 代表科罗拉多大学和危地马拉大学之间的合作伙伴关系是发展和 实施特定营养的干预措施，以减轻产前和产后营养不良的影响，从而减轻 改善孕产妇和婴儿的健康结果。该目标将通过以下特定目的实现： 1）继续保持强大的研究记录和GN成员的生产力； 2）继续养育 与我们在危地马拉和其他GN站点的同事逐步更强大的研究合作伙伴关系； 3） 继续开发营养特定的干预措施作为GN通用方案。在过去的5年周期中， Ru建立了强大的研究记录，这证明了两个主要营养特定的普通 方案，包括孕妇营养干预试验；加强了研究 危地马拉的能力；参与所有GN引发的共同的开发和实施 每项研究的群集/参与者数量的贡献很高；强的 出版物中的生产力（总共有60个与GN合着者）报告了GN支持试验的结果；和 成功获得了主要的外部资金以支持共同的协议实施。主要的 此RU对GN的贡献包括共同主持协议审查小组委员会和监督 正在进行的孕产妇卫生注册表委员会。成功的指导和能力建设 NICHD的邀请证明了RU。 寨卡病毒在怀孕期间暴露的观察性研究。我们继续参与的积极影响 在GN中，将通过识别营养来增强全球网络的多学科能力 - 具体的干预措施以改善孕产妇和婴儿健康。这样的协作研究将加速 制定基于循证的政策，以减轻全球营养不良负担和其他不利健康的负担 结果。