Multidisciplinary Training in the Biology of Alcohol Addiction

酒精成瘾生物学的多学科培训

• 批准号: 10412007
• 负责人: BRIAN A MCCOOL
• 金额: $ 47.6万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10412007
• 关键词: Alcohol dependence; Biology; Training; multidisciplinary

This renewal application is for a T32 training grant which provides support for five predoctoral and three postdoctoral trainees in basic alcohol research at Wake Forest School of Medicine. The objectives of the training program are to 1) provide multi-disciplinary training in the neurobiology of alcohol abuse and addiction and 2) produce independent, productive scientists for the alcohol research community. Our rationale for the proposed training arises from our diverse training faculty - a group of well-funded alcohol investigators with solid expertise in basic, preclinical, and human-subjects research - who have successfully trained young scientists within this program for over twenty-five years. Our highly collaborative and multidisciplinary environment fosters trainees to gather the necessary skills to become independent investigators and to operate within interdisciplinary teams that will increasingly characterize the future of biomedical research. The alcohol research that characterizes our training environment is also highly translational. First, virtually all of our training labs employ, examine, and publish in alcohol self- administration; this has characterized the training program from its inception. The training program now also spans experimental model systems from mice and rats, monkeys, individual humans, to human populations. Finally, many of our training faculty employ overlapping experimental approaches, examine some of the same experimental end points, and/or employ the some of the same behavioral models across multiple species. Our training design therefore consists of both rigorous didactic instruction as well as intensive laboratory-based research. It is augmented by a robust curriculum in career development, including teaching, grant- and manuscript-writing courses, and ethics. There are multiple opportunities for students and postdoctoral fellows to hone presentation skills including journal clubs, data clubs, and required research seminar presentations both at the institution and at national meetings. As a condition for reappointment to the training program, we require our all trainees apply for individual NRSAs (or independent private support) during their training and to publish in peer-reviewed journals. This requirement helps sharpen grant and manuscript writing skills that are critical in today's research environment. We also attempt to limit predoctoral trainees to less than three years of support on the training grant. This time-limit ensures that the training grant provides support to the best, brightest, and most productive students and fellows at Wake Forest School of Medicine. Our program also benefits from distinct school resources that include a Clinical Translational Science Institute which offers courses in translational research, a nationally-recognized primate center with several different populations of monkeys including a fully pedigreed and genotyped vervet colony, and state-of-the-art imaging facilities that can accommodate humans, non-human primates, and rodents. Finally, we partner with resident psychiatrists and psychologists to give our students clinical exposure to current and long-abstinent patients. This enhances their understanding of alcohol abuse disorders and grounds their research in the real world.

此续订申请是用于T32培训补助金，该培训赠款为五个五次和三个 维克森林医学院基本酒精研究的博士后学员。目标的目标 培训计划是1）在酗酒和 成瘾和2）为酒精研究界创造独立的生产科学家。我们的 拟议培训的理由来自我们多样化的培训学院 - 一群资金充足的酒精 在基本，临床前和人类受试者研究方面具有扎实专业知识的研究人员 - 成功 在该计划中培训了年轻的科学家二十五年以上。我们高度协作和 多学科环境培养学员，以收集必要的技能以成为独立 调查人员并在跨学科团队中运作，这些团队将越来越多地描述 生物医学研究。我们培训环境的特征的酒精研究也很高 翻译。首先，我们几乎所有的培训实验室都采用，检查和出版在酒精中 行政;这是从其成立开始的培训计划的特征。培训计划现在也 跨越小鼠和大鼠，猴子，单个人类的实验模型系统，到人类人群。 最后，我们的许多培训教师采用重叠的实验方法，检查其中的一些 实验性终点和/或在多种物种中采用了一些相同的行为模型。我们的 因此，培训设计包括严格的教学教学以及基于密集的实验室 研究。它在职业发展中的强大课程增强了，包括教学，授予和 手稿编写课程和道德规范。学生和博士后研究员有很多机会 磨练演示技巧，包括期刊俱乐部，数据俱乐部和必需的研究研讨会演示文稿 在机构和国家会议上。作为重新任命培训计划的条件，我们 要求我们的所有受训者在培训期间申请单独的NRSA（或独立私人支持）， 在同行评审的期刊上发布。这项要求有助于提高赠款和手稿写作技巧 在当今的研究环境中至关重要。我们还试图将少量学员限制在少于三个 多年支持培训补助金。这个时间限制可确保培训赠款为 Wake Forest医学院最好，最聪明，最有生产力的学生和研究员。我们的计划 还从不同的学校资源中受益，包括临床转化科学研究所 转化研究课程，一个全国认可的灵长类动物中心，有几个不同的人群 猴子在内，包括一个完全的基因型和基因型的vervet殖民地以及最先进的成像设施 可以容纳人类，非人类灵长类动物和啮齿动物。最后，我们与常驻精神科医生合作 和心理学家，使我们的学生临床接触当前和长期的患者。这增强了 他们对酗酒障碍的理解和在现实世界中的研究为基础。