1/1 INIA Stress and Chronic Alcohol Interactions: Administrative Resource

1/1 INIA 压力和慢性酒精相互作用：行政资源

• 批准号: 10409279
• 负责人: KATHLEEN A GRANT
• 金额: $ 29.72万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10409279
• 关键词: Abstinence; Address; Alcohol consumption; Alcohol dependence; Alcoholism; Alcohols; Amygdaloid structure; Animal Model; Anxiety; Arousal; Behavioral; Behavioral Model; Brain; Brain Stem; Chronic; Cognitive; Collection; Communities; Data; Development; Diagnostic; Endocrine; Executive Dysfunction; Exposure to; Functional Imaging; Gene Activation; Genetic; Goals; Grant; Heavy Drinking; Human; Hypothalamic structure; Impairment; Individual; Individual Differences; Knowledge; Lead; Leadership; Link; Mediating; Memory; Motivation; Neurons; Neurosciences; Neurotransmitters; Output; Perception; Pharmacotherapy; Physiological; Predisposition; Prevention; Process; Recovery; Relapse; Research; Research Activity; Research Project Grants; Resources; Risk; Sensory; Spectrum Analysis; Stress; Stressful Event; Structure; System; Techniques; Technology; Time; alcohol exposure; alcohol measurement; alcohol research; alcohol risk; alcohol use disorder; allostasis; animal data; anxiety states; anxiety-like behavior; brain circuitry; brain magnetic resonance imaging; comorbidity; drinking; effective therapy; executive function; flexibility; hazardous drinking; hypothalamic-pituitary-adrenal axis; indexing; individualized medicine; innovation; longitudinal design; multidisciplinary; negative emotional state; neural circuit; neuroadaptation; neuromechanism; personalized medicine; relating to nervous system; response; sensor; social; stress reactivity; stress related disorder; stress state; stressor; treatment strategy

PROJECT SUMMARY The consortium Integrative Neuroscience Initiative on Alcoholism: Stress and Chronic Alcohol Interactions (a.k.a. INIAstress) is a collection of highly integrative and innovative projects and cores. The overarching goal of INIAstress is elucidating the changes in brain circuitry and mechanisms that underlie how chronic alcohol alters response to stress, which in turn can facilitate the transition from moderate/social drinking to heavy/hazardous drinking and associated problems. The consortium has defined factors that contribute to an individual's risk for the development of alcohol use disorder (AUD), revealed underlying mechanisms and conditions that promote excessive and harmful drinking, and forged progress towards discovering more effective and tailored treatment strategies. In the next renewal, the overarching goal of the INIAstress Consortium is to apply cutting-edge technologies towards elucidating mechanisms of neural adaptation in key brain circuitry that underlie how alcohol and stress interact to facilitate a trajectory toward excessive drinking, a negative emotional state, cognitive (executive) function deficits, and harmful abstinence/relapse cycles. Through this knowledge the consortium will advance personalized medicine approaches to facilitate recovery from AUD and, in particular, stress-related excessive alcohol consumption. Collectively, these collaborative, cross-species studies directly integrate behavioral, endocrine, neural, and genetic data within a scope of expertise and thematic inquiry that would not be possible using more traditional grant mechanisms. As the lead application, the Administrative Resource Core will provide scientific leadership on the consortium's main goals and serve as a centralized administrative structure to facilitate and coordinate the overall management, direction and integration of research activities within the INIAstress Consortium.

项目摘要 酗酒的联盟综合神经科学倡议：压力和慢性酒精相互作用 （又名Iniastress）是高度综合和创新的项目和核心的集合。总体 非洲血统的目标是阐明脑电路的变化和机制的变化，这些机制是慢性如何 酒精会改变对压力的反应，这又可以促进从中等/社交饮酒到 沉重/危险的饮酒和相关问题。该财团已定义了有助于 个人发生饮酒障碍（AUD）的风险，揭示了潜在的机制和 促进过度和有害饮酒的条件，并伪造了进步，以发现更有效 和量身定制的治疗策略。在下一个续约中，非洲人财团的总体目标是 在关键脑电路中阐明神经适应机制的尖端技术， 酒精和压力如何相互作用以促进过度饮酒的轨迹，一种负面情绪 状态，认知（执行）功能缺陷以及有害的禁欲/复发周期。通过这些知识 财团将推进个性化医学方法，以促进从AUD恢复，尤其是 与压力有关的过度饮酒。总的来说，这些合作的跨物种研究直接 将行为，内分泌，神经和遗传数据整合到专业知识范围内 使用更传统的赠款机制是不可能的。作为领导应用程序， 行政资源核心将为财团的主要目标提供科学领导，并将其作为 一种集中的行政结构，以促进和协调整体管理，方向和 在无罪群体中的研究活动的整合。