Intergenerational Transmission of Deficits In Self-Regulatory Control

自律控制缺陷的代际传递

• 批准号: 10409776
• 负责人: RACHEL MARSH
• 金额: $ 74.34万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10409776
• 关键词: Adult; Age; Age-Months; Behavior; Behavioral; Biological; Biomedical Research; Birth; Brain; Child; Childhood; Cognitive; Conduct Disorder; Conflict (Psychology); Corpus striatum structure; Data; Development; Emotional; Emotions; Enrollment; Epigenetic Process; Family; Functional Magnetic Resonance Imaging; Future; Generations; Healthcare; Individual Differences; Infant; Intervention; Latina; Life; MRI Scans; Magnetic Resonance Imaging; Measures; Mediating; Medical center; Mental disorders; Methods; Mothers; National Institute of Mental Health; Neonatal; Nursery Schools; Outcome; Parietal; Partner in relationship; Patient Self-Report; Pattern; Performance; Population; Populations at Risk; Precision Medicine Initiative; Pregnancy; Pregnant Women; Prevention strategy; Process; Process Measure; Reporting; Research Domain Criteria; Resources; Rest; Risk; Sampling; Scanning; School-Age Population; Stress; Student Dropouts; Study models; Teenagers; Thinking; Third Pregnancy Trimester; United States National Institutes of Health; Woman; Youth; base; behavior measurement; behavioral outcome; brain behavior; follow-up; high risk; imaging modality; indexing; infancy; intergenerational; maladaptive behavior; multimodality; neonatal brain; neonatal period; neonate; novel; offspring; personalized predictions; postnatal; predictive modeling; pregnant teen; prenatal; prevent; psychosocial; recruit; teration; transmission process

PROJECT SUMMARY Self-regulatory deficits are common across a variety of childhood psychiatric disorders in which children have difficulty regulating their thoughts, emotions, and behaviors. By leveraging previously collected prenatal and neonatal data and acquiring new data from mother-infant dyads, this study will identify circuit-based markers of regulatory deficits that are passed inter-generationally, and persist from infancy to childhood. We will enroll 15- 45 year-old pregnant women/mothers, approximately 75% Latina, who are receiving health care from our ur- ban medical center, a sample that is underrepresented in U.S. biomedical research and facing significant psy- chosocial adversity. Age-appropriate measures of regulatory control processes will be acquired from their off- spring at 4- and 14-months and during preschool and school age, including resting-state fMRI data from neo- nates and both resting and task-based fMRI data from school-aged children who were previously scanned as neonates. Behavioral measures of regulatory capacity and resting and task-based fMRI will also be acquired from the mothers, allowing us to associate maternal-neonatal indices of self-regulatory control. Thus, this study will uncover trajectories of control processes and circuits from infancy to school age and the intergenerational transmission of regulatory deficits from mothers to offspring. Findings will set the stage for future research aimed at engaging these circuits as targets for strategies to prevent the risk for future maladaptive behaviors and at identifying prenatal mechanisms underlying the intergenerational transmission of regulatory deficits, such as epigenetic and stress-mediated biological alterations. This study supports the NIMH strategic objective to chart mental illness trajectories to determine when, where, and how to intervene by elucidating the develop- ment of regulatory control across the first decade of life. This study also supports both the NIH BRAIN and pre- cision medicine initiatives by evaluating the functional organization of control circuits across family generations and longitudinally, as well as using a novel imaging method to predict behavioral outcomes.

项目摘要 在各种儿童患有儿童的精神疾病中，自我调节性缺陷很常见 难以调节他们的思想，情感和行为。通过利用先前收集的产前和 新生儿数据并从母亲二元组中获取新数据，本研究将确定基于电路的标记 经常性通过，从婴儿期到童年的监管缺陷。我们将注册15- 45岁的孕妇/母亲，大约75％的拉丁裔，他们正在我们的UR- Ban Medical Center，该样本在美国生物医学研究中的人数不足，面临着重要的PSY- 社会逆境。适合监管控制过程的年龄措施将从其外部获得 春季在4个月和14个月以及学龄前和学龄期间，包括NEO-的休息状态fMRI数据 Nates以及以前被扫描为学龄儿童 新生儿。也将获得监管能力和休息和基于任务的fMRI的行为度量 来自母亲，使我们能够将自我调节性控制的孕产妇 - 神经指标联系起来。因此，这项研究 将发现从婴儿期到学龄的控制过程和电路的轨迹 监管缺陷从母亲传播到后代。调查结果将为将来的研究奠定舞台 旨在使这些电路作为防止未来适应不良行为风险的策略的目标 并在确定监管缺陷的代际传播基础的产前机制时， 例如表观遗传和应激介导的生物学改变。这项研究支持NIMH的战略目标 绘制精神疾病轨迹以确定何时，何地和如何通过阐明发展 - 在生命的前十年中，监管控制。这项研究还支持NIH大脑和前 Cision Medicine Initiation通过评估家庭几代人的控制电路的功能组织 纵向，并使用一种新型的成像方法来预测行为结果。