Animal Metabolic Physiology Core

动物代谢生理学核心

• 批准号: 10408481
• 负责人: DAVID H WASSERMAN
• 金额: $ 22.69万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-12-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10408481
• 关键词: Address; Adipose tissue; Animal Model; Animals; Bariatrics; Blood Vessels; Cannulations; Catheterization; Cell Communication; Communities; Consult; Data; Development; Diabetes Mellitus; Equipment; Feedback; Funding; Gastrointestinal Surgical Procedures; Genomics; Grant; Human; Incentives; Indirect Calorimetry; Individual; Infrastructure; Islets of Langerhans Transplantation; Laboratories; Light; Metabolic; Metabolic Diseases; Mus; National Institute of Diabetes and Digestive and Kidney Diseases; Pancreas; Participant; Physiological; Physiology; Procedures; Publications; Research; Research Personnel; Research Technics; Resources; Role; Services; Standardization; Strategic Planning; Students; Surveys; Techniques; Technology; Telemetry; Temperature; Time; Training; base; design; experience; experimental study; flexibility; implantation; in vivo; in vivo Model; intravital microscopy; investigator training; islet; metabolic abnormality assessment; metabolic phenotype; mouse model; programs

Animal Metabolic Physiology Core: Project Summary/Abstract The Animal Metabolic Physiological Core (AMPC) is a new Vanderbilt Diabetes Research Center (VDRC) Core. In prior VDRC cycles, mouse services for VDRC investigators had been provided by the Vanderbilt Mouse Metabolic Phenotyping Center (MMPC; U24 DK059637). The Vanderbilt MMPC, an original and continuous participant in the national MMPC national program, has been on the forefront of development, standardization, and dissemination of techniques to study metabolism in mice for 20 years. NIDDK will retire the national MMPC Program in June 2021. At the time this was announced, the VDRC was engaged in strategic planning for its competitive renewal. VDRC investigators expressed concern as to how funded grants could be executed and new scientific projects developed without these mouse services. Thus, the VDRC proposes to create the AMPC to make these mouse services available to VDRC investigators. The rationale for the AMPC is based on overwhelming feedback from VDRC investigators expressing a need to continue the sophisticated mouse services that had been so impactful in their research (54 VDRC users, >24,000 services, 98 publications used this type of service in past 5 years). The AMPC will provide state-of-the-art research techniques and expert guidance in integrative metabolic physiology to VDRC investigators. The AMPC services and expensive equipment that will be made available through the AMPC are impractical to develop or acquire and maintain in the lab of an individual investigator. Plus, the AMPC’s expertise and services overcome barriers to studying the mouse and are highly integrated with VDRC services provided by the Analytical Services Core, the Genomics and Human Physiology Core, and the Islet and Pancreas Analysis Core. The AMPC will have an important role in training of fellows, students and staff which will serve to propagate valuable concepts and technology. Thus, the AMPC and its services are vital to address the research aims of funded grants and for the development of new scientific projects for VDRC investigators.

动物代谢生理核心：项目摘要/摘要 动物代谢生理核心（AMPC）是新的范德比尔特糖尿病研究中心（VDRC） 核。在先前的VDRC周期中，Vanderbilt为VDRC调查人员提供了鼠标服务 小鼠代谢表型中心（MMPC; U24 DK059637）。 Vanderbilt MMPC，原件和 国家MMPC国家计划的持续参与者一直处于发展的最前沿， 标准化以及研究小鼠新陈代谢的技术20年。 NIDDK将退休 2021年6月的国家MMPC计划。当时宣布，VDRC参与了 竞争性更新的战略规划。 VDRC调查人员对资金赠款的方式表示关注 可以执行，没有这些鼠标服务的新科学项目。那，vdrc 提出创建AMPC的建议，以使VDRC调查人员可用这些鼠标服务。理由 AMPC基于VDRC调查人员的压倒性反馈，表示需要继续 软化的鼠标服务在他们的研究中产生了影响（54个VDRC用户，> 24,000个服务， 98个出版物在过去5年中使用了这种服务）。 AMPC将提供最先进的研究 VDRC研究人员的综合代谢生理学技术和专家指导。 AMPC 通过AMPC提供的服务和昂贵的设备不切实际地开发或 在个人调查员的实验室中获取并维护。另外，AMPC的专业知识和服务 克服研究鼠标的障碍，并与由VDRC服务高度整合 分析服务核心，基因组学和人类生理核心以及胰岛和胰腺分析 核。 AMPC将在培训研究员，学生和教职员工中发挥重要作用 传播宝贵的概念和技术。这，AMPC及其服务对于解决 资金赠款的研究目的以及为VDRC研究人员开发新的科学项目。