Clinical Translational Research Core

临床转化研究核心

• 批准号: 10407757
• 负责人: LORI M LAFFEL
• 金额: $ 24.27万
• 依托单位: JOSLIN DIABETES CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-15 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10407757
• 关键词: Adipose tissue; Adult; Algorithms; Angiography; Anthropometry; Back; Biological; Biology; Biopsy; Blood Vessels; Body Composition; Bone Density; Brown Fat; Caring; Catalogs; Childhood; Clinic; Clinical; Clinical Data; Clinical Investigator; Clinical Research; Clinical Trials; Closure by clamp; Cohort Analysis; Collaborations; Collection; Complex; Complications of Diabetes Mellitus; Consultations; Core Facility; Data; Data Analyses; Development; Diabetes Mellitus; Dietary Intervention; Dual-Energy X-Ray Absorptiometry; Electroretinography; Energy Metabolism; Equipment; Evaluation; Evolution; Exercise; Exercise Test; Family; Fatty acid glycerol esters; Functional disorder; Funding; Glomerular Filtration Rate; Glucose; Gold; Home; Human; Hyperglycemia; Hypoglycemia; Infrastructure; Infusion procedures; Institution; Insulin; Insulin-Dependent Diabetes Mellitus; Intravenous; Investigation; Link; Liquid substance; Measurement; Measures; Mentors; Metabolic; Metabolic Diseases; Metabolism; Methodology; Methods; Modeling; Muscle; Neighborhoods; Non-Insulin-Dependent Diabetes Mellitus; Optical Coherence Tomography; Oral; Patient Care; Performance; Pharmacology; Physiological; Physiological Processes; Population; Prevention; Procedures; Process; Protocols documentation; Publications; Research; Research Design; Research Personnel; Resources; Retina; Sampling; Science; Scientist; Services; Skin; Specimen; Techniques; Technology; Testing; Tissue Sample; Tracer; Training; Translating; Translational Research; Visualization; base; biobank; clinical investigation; clinical trial implementation; data management; design; epidemiology study; exercise intervention; exercise training; first-in-human; fitness; glucose monitor; improved; insulin secretion; interdisciplinary collaboration; man; patient oriented; patient population; pediatric patients; pharmacokinetics and pharmacodynamics; programs; translational impact; translational research program; translational study; treatment optimization

CLINICAL TRANSLATIONAL RESEARCH CORE: Abstract The Joslin Clinical Translational Research Core (CTRC) provides infrastructure for the conduct of high-quality clinical and translational research in diabetes and metabolism. This is done by facilitating access to appropriate patient populations as well as providing specialized facilities and expertise focused on clinical research related to the pathophysiology, prevention and treatment of diabetes, its complications, and related metabolic disorders. Since it was established in the last funding cycle, the CTRC has provided consultative services for study design and regulatory guidance. Physical infrastructure and well-trained nusing and technical staff assist investigators in safely carrying out gold standard euglycemic, hyperglycemic, and hypoglycemic clamps at physiologic or pharmacologic insulin concentrations; intravenous and oral glucose and mixed meal tolerance tests; and other metabolic testing to assess insulin secretion, insulin action, and other physiologic processes for patient-centered research specific to diabetes and metabolism. In addition expertise and equipment are available for exercise training and testing capacities, dual-energy X-ray absorptiometry for assessment of bone density and body composition, electroretinogram and optical coherence tomography angiography for visualization of retinal function and vasculature, continuous glucose monitor data analayses, cooling vests for brown fat activation, metabolic assessments, bioimpedance analysis, and anthropometry. CTRC facilities and procedures allow for the sampling of various biologic fluids, performance of pharmacokinetic and pharmacodynamic studies and physiologic measurements, and protocols for skin, muscle and adipose tissue sampling. Additionally, the Core has established a diabetes-specific Biorepository that facilitates discovery of and access to biospecimens and linked data. In this application, we propose to provide resources for “T1” translational research programs with specific focus on prediction, prevention, and interdiction of type 1 or type 2 diabetes and related complications; to facilitate design, implementation, and evaluation of investigator-initiated clinical trials and epidemiologic studies for “T2-T3” research programs focused on improving/optimizing treatments of diabetes and related complications; and to expand the CTRC Biorepository. These represent efforts that will build research capacity for translating new discoveries into improvement in the treatment, prevention and ultimately, the cure of diabetes.

临床翻译研究核心：摘要 Joslin临床翻译研究核心（CTRC）为进行高质量的进行基础设施提供了基础设施 糖尿病和代谢的临床和翻译研究。这是通过促进适当的访问来完成的 患者人群以及提供有关临床研究相关的专业设施和专业知识 糖尿病的病理生理学，预防和治疗，其并发症和相关代谢性疾病。 由于它是在最后一个资金周期中建立的，因此CTRC为研究设计提供了咨询服务 和监管指导。物理基础设施和训练有素的杜松子酒和技术人员协助调查人员 在生理或 药理胰岛素浓度；静脉和口服葡萄糖以及混合餐耐受性测试；还有其他 代谢测试以评估以患者为中心的胰岛素分泌，胰岛素作用和其他生理过程 研究特定于糖尿病和代谢。此外，专业知识和设备可用于锻炼 训练和测试能力，双能X射线绝对能力测定法，用于评估骨密度和身体 组成，电视图和光学相干断层扫描血管造影用于视网膜的可视化 功能和脉管系统，连续的葡萄糖监测数据分析，冷却背心用于棕色脂肪激活， 代谢评估，生物阻抗分析和人体测量法。 CTRC的设施和程序允许 对各种生物液的取样，药代动力学和药效研究的性能以及 生理测量以及皮肤，肌肉和脂肪组织采样方案。另外，核心 已经建立了一个糖尿病特异性的生物疗法，以促进发现并获得生物测量和获取 链接数据。在此应用程序中，我们建议与“ T1”翻译研究计划的资源 针对1型或类型2型糖尿病及相关并发症的预测，预防和拦截的特定重点； 促进研究人员发射的临床试验和流行病学的设计，实施和评估 “ T2-T3”研究计划的研究重点是改善/优化糖尿病治疗及相关治疗 并发症；并扩大CTRC生物座席。这些代表将增强研究能力的努力 为了将新发现转化为治疗，预防以及最终治愈糖尿病的改善。