Core G Neuropath

核心 G 神经病

• 批准号: 10408059
• 负责人: JUAN TRONCOSO
• 金额: $ 7.4万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10408059
• 关键词: Age; Aging; Alzheimer' s Disease; Autopsy; Baltimore; Biological; Biological Markers; Blood; Brain; Brain imaging; Brain scan; Cessation of life; Clinical; Cognition; Cognitive; Correlation Studies; Data; Diagnosis; Documentation; Enrollment; Gene Expression; Goals; Image; Impaired cognition; Individual; Informatics; Investigation; Longitudinal Studies; Longitudinal observational study; Magnetic Resonance Imaging; Methods; Microscopic; Molecular Genetics; Morphology; Participant; Pathogenesis; Pattern; Positron-Emission Tomography; Procedures; Protocols documentation; Registries; Research; Research Personnel; Specimen; Time; Tissue Sample; Transportation; Work; age related; base; brain tissue; central database; cohort; diagnostic criteria; hospital performance; member; middle age; neuropathology; novel marker; pre-clinical; preclinical study; prospective; rate of change

NEUROPATHOLOGY CORE – CORE G: PROJECT SUMMARY/ABSTRACT The BIOCARD study is a longitudinal, observational study of 349 individuals who were cognitively normal and primarily middle aged (mean age=57.1) at enrollment. The subjects have now been followed for up to 27 years. The overall objectives of the project are to further advance the study of preclinical Alzheimer’s disease by: (1) clarifying the pattern and rate of change in AD biomarkers (including those based on CSF, blood, MRI, and PET imaging) and cognition; the biomarkers to be studied include several promising novel biomarkers derived from blood, CSF and brain imaging. (2) maximizing our data by working collaboratively with several research groups who have comparable data, and (3) providing a publicly accessible data, brain scans, and biological specimens, for researchers in the field. To accomplish these goals we established 7 Cores and, with this application, are also including 2 projects. The Neuropathology Core (Core G) is responsible for overseeing the neuropathological assessment of brain tissue from participants in the BIOCARD study and for assuring the integration of these findings with relevant data collected by the other Cores and Projects. The specific aims include: (1) to maintain a registry of prospective brain donors, (2) to arrange and perform neuropathologic autopsies, (3) to provide neuropathologic diagnoses, (4) to integrate neuropathology data with data from other Cores and Projects, (5), to prepare, store and distribute autopsy brain tissue for research, and (6) to continue investigations of the early pathogenesis of Alzheimer’s disease.

神经病理学核心 - 核心G：项目摘要/摘要 Biocard研究是一项纵向，观察性研究，对349个认知正常和 初级中年（平均年龄= 57.1）入学时。现在，受试者已被遵循长达27年。 该项目的总体目标是进一步促进研究阿尔茨海默氏病的研究 作者：（1）澄清AD生物标志物的模式和变化速率（包括基于CSF，血液，MRI， 和宠物成像）和认知；要研究的生物标志物包括几种有望的小说生物标志物 源自血液，CSF和大脑成像。 （2）通过与几个合作合作，使我们的数据最大化 具有可比数据的研究小组以及（3）提供公开访问的数据，脑部扫描和 生物标本，适用于该领域的研究人员。为了实现这些目标，我们建立了7个核心，并与 该应用程序还包括2个项目。神经病理学核心（核心G）负责 监督Biocard研究参与者对脑组织的神经病理学评估 并确保将这些发现与其他核心收集的相关数据整合在一起， 项目。具体目的包括：（1）维护准脑捐献者的注册表，（2）安排和 进行神经病理学尸检，（3）提供神经病理学诊断，（4）整合神经病理学 带有来自其他核心和项目的数据（5）的数据，以准备，存储和分发尸检脑组织 研究和（6）继续研究阿尔茨海默氏病的早期发病机理。