Core B Clinical

核心B临床

• 批准号: 10408054
• 负责人: MARILYN S. ALBERT
• 金额: $ 159.74万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10408054
• 关键词: Age; Alzheimer' s Disease; Alzheimer’s disease biomarker; Autopsy; Biological; Biological Markers; Blood; Brain imaging; Brain scan; Cerebrospinal Fluid; Clinical; Clinical Data; Clinical assessments; Cognition; Cognitive; Collection; Consensus; Data; Data Analyses; Diagnosis; Enrollment; Evaluation; Funding; Goals; Holidays; Home visitation; Impaired cognition; Individual; Informatics; Longitudinal observational study; MRI Scans; Magnetic Resonance Imaging; Participant; Pattern; Persons; Phase; Pittsburgh Compound-B; Positron-Emission Tomography; Procedures; Research; Research Personnel; Schedule; Specimen; Spinal Puncture; United States National Institutes of Health; Update; Visit; Work; base; clinical diagnosis; cognitive testing; cohort; data sharing; follow-up; meetings; member; middle age; neuropathology; novel marker; pre-clinical; preclinical study; rate of change; recruit; screening; tau Proteins

CLINICAL CORE – CORE B: PROJECT SUMMARY/ABSTRACT The BIOCARD study is a longitudinal, observational study of 349 individuals who were cognitively normal and primarily middle aged (mean age=57.1) at enrollment. The subjects have now been followed for up to 27 years. The overall objectives of the project are to further advance the study of preclinical Alzheimer’s disease by: (1) clarifying the pattern and rate of change in AD biomarkers (including those based on CSF, blood, MRI, and PET imaging) and cognition; the biomarkers to be studied include several promising novel biomarkers derived from blood, CSF and brain imaging. (2) maximizing our data by working collaboratively with several research groups who have comparable data, and (3) providing a publicly accessible data, brain scans, and biological specimens, for researchers in the field. To accomplish these goals we established 7 Cores and, with this application, are also including 2 projects. The Clinical Core (Core B) has a wide range of responsibilities related to the evaluation and follow-up of the subjects in the BIOCARD study. The specific aims include: (1) screening and enrollment of the new study participants, (2) scheduling subjects for all visits and all study procedures, (3) completion of the annual clinical and cognitive assessments and consensus diagnoses, and accompanying subjects to all additional study procedures, (4) acquisition of ante-mortem autopsy approval, (5) assistance with subject retention activities, (6) analysis of the clinical and cognitive data and working with other Cores and Projects to integrate the clinical and cognitive data into their analyses, and (7) working with the Informatics Core to assure that the clinical and cognitive data shared with outside investigators is as accurate as possible.

临床核心 - 核心B：项目摘要/摘要 Biocard研究是一项纵向，观察性研究，对349个认知正常和 初级中年（平均年龄= 57.1）入学时。现在，受试者已被遵循长达27年。 该项目的总体目标是进一步促进研究阿尔茨海默氏病的研究 作者：（1）澄清AD生物标志物的模式和变化速率（包括基于CSF，血液，MRI， 和宠物成像）和认知；要研究的生物标志物包括几种有望的小说生物标志物 源自血液，CSF和大脑成像。 （2）通过与几个合作合作，使我们的数据最大化 具有可比数据的研究小组以及（3）提供公开访问的数据，脑部扫描和 生物标本，适用于该领域的研究人员。为了实现这些目标，我们建立了7个核心，并与 该应用程序还包括2个项目。临床核心（核心B）具有广泛的 与生物卡研究中对象的评估和随访有关的责任。这 具体目的包括：（1）筛选和入学新研究参与者，（2）所有人安排主题 访问和所有研究程序，（3）完成年度临床和认知评估和共识 诊断和参与所有其他研究程序的受试者，（4）获取静止 尸检批准，（5）对主题保留活动的帮助，（6）分析临床和认知数据 并与其他核心和项目合作，将临床和认知数据整合到他们的分析中，并 （7）与信息核心合作，以确保与外部共享的临床和认知数据 调查人员尽可能准确。