Core D Biospecimen

核心 D 生物样本

• 批准号: 10408056
• 负责人: Abhay Moghekar
• 金额: $ 46.2万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10408056
• 关键词: Age; Alzheimer' s Disease; Amyloid beta-42; Biological; Biological Assay; Biological Markers; Blood; Blood specimen; Brain imaging; Brain scan; Catalogs; Cell Line; Centrifugation; Cerebrospinal Fluid; Clinical; Cognition; Cognitive; Collection; Data; Diagnostic; Enrollment; Fasting; Freezing; Funding; Goals; Impaired cognition; Impairment; Individual; Light; Lipids; Longitudinal observational study; Magnetic Resonance Imaging; Measures; Medial; Methods; Participant; Pattern; Phase; Positron-Emission Tomography; Procedures; Process; Reporting; Research; Research Personnel; Role; SYNJ1 gene; Signal Transduction; Specimen; TREM2 gene; Temperature; Temporal Lobe; Time; Tube; base; cell immortalization; cohort; data sharing; improved; insight; insulin signaling; middle age; neurofilament; neuroinflammation; novel marker; pre-clinical; preclinical study; rate of change; recruit; tau Proteins; tau-1

BIOSPECIMEN CORE – CORE D: PROJECT SUMMARY/ABSTRACT The BIOCARD study is a longitudinal, observational study of 349 individuals who were cognitively normal and primarily middle aged (mean age=57.1) at enrollment. The subjects have now been followed for up to 27 years. The overall objectives of the project are to further advance the study of preclinical Alzheimer’s disease by: (1) clarifying the pattern and rate of change in AD biomarkers (including those based on CSF, blood, MRI, and PET imaging) and cognition; the biomarkers to be studied include several promising novel biomarkers derived from blood, CSF and brain imaging. (2) maximizing our data by working collaboratively with several research groups who have comparable data, and (3) providing a publicly accessible data, brain scans, and biological specimens, for researchers in the field. To accomplish these goals we established 7 Cores and, with this application, are also including 2 projects. The Biospecimen Core (Core D) is responsible for overseeing the acquisition and analysis of cerebrospinal fluid and blood in the BIOCARD study participants. The specific aims include: (1) to collect, catalog and store cerebrospinal fluid (CSF) and blood specimens from the participants, (2) to perform state-of-the-art CSF assays of the specimens collected in the study participants, (3) to examine the effect of pre-analytic variables on the CSF assays of Abeta42, tau and p- tau, (4) to measure several additional assays in CSF, including synaptojanin1 (SynJ1), klotho and soluble TREM2 (sTREM2), (5) to integrate the CSF and blood measures generated by Core D and Project 1 with the clinical, cognitive, MRI and PET measures collected in the other Cores, (6) and to continue to share data derived from the biospecimens in this study with investigators in the field, and to share specimens, as appropriate.

Biospecimen Core - 核心D：项目摘要/摘要 Biocard研究是一项纵向，观察性研究，对349个认知正常和 初级中年（平均年龄= 57.1）入学时。现在，受试者已被遵循长达27年。 该项目的总体目标是进一步促进研究阿尔茨海默氏病的研究 作者：（1）澄清AD生物标志物的模式和变化速率（包括基于CSF，血液，MRI， 和宠物成像）和认知；要研究的生物标志物包括几种有望的小说生物标志物 源自血液，CSF和大脑成像。 （2）通过与几个合作合作，使我们的数据最大化 具有可比数据的研究小组以及（3）提供公开访问的数据，脑部扫描和 生物标本，适用于该领域的研究人员。为了实现这些目标，我们建立了7个核心，并与 该应用程序还包括2个项目。 Biospecemen Core（核心D）负责 在生物卡研究中监督脑脊液和血液的获取和分析 参与者。具体目的包括：（1）收集，目录和存储脑脊液（CSF）和血液 参与者的标本，（2）以在收集的标本中执行最先进的CSF测定 研究参与者，（3）检查临时变量对ABETA42，TAU和P-的CSF测定的影响 tau，（4）在CSF中测量几个其他测定法 TREM2（Streem2），（5）整合了CSF和Core D和Project 1产生的血液测量 在其他内核中收集的临床，认知，MRI和PET测量，（6），并继续共享数据 在本研究中与该领域的研究人员一起源自生物测量，并共享标本 合适的。