Third Coast Center For AIDS Research

第三海岸艾滋病研究中心

• 批准号: 10405457
• 负责人: Richard D'Aquila
• 金额: $ 471.66万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-09 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10405457
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Adherence; African American; Aging; Aquila; Behavioral; Behavioral Sciences; Biological Assay; Biological Markers; Blood; Caring; Cells; Chicago; Clinical; Clinical Sciences; Collaborations; Communities; Computational Science; Consultations; Data Analytics; Data Science; Development; Diagnostic; Discipline; Disease; Disease remission; Doctor of Philosophy; Engineering; Epidemic; Foundations; Funding; Growth; HIV; Health; Health Professional; Heart; Illinois; Image; Immunity; Informatics; Infrastructure; Intervention; Magic; Market Research; Mentored Clinical Scientist Development Program; Mentors; Mission; Modeling; National Heart, Lung, and Blood Institute; Network Infrastructure; Outcome; Partnership Practice; Persons; Populations at Risk; Prevention; Productivity; Public Health; Reporting; Research; Research Personnel; Resources; Risk; Science; Scientist; Seeds; Sleep; Social Sciences; Solid; Specimen; Speed; Strategic Planning; Systems Biology; Technology; Testing; Translational Research; Universities; Ursidae Family; Viral; Viral Pathogenesis; Viremia; Vulnerable Populations; Work; base; clinical phenotype; cohort; community engagement; community organizations; comorbidity; design; effective intervention; health data; healthspan; implementation science; improved; innovation; interdisciplinary collaboration; men; multidisciplinary; pre-exposure prophylaxis; programs; recruit; social; success; synergism; transgender women; translational pipeline; virology; working group; young men who have sex with men

PROJECT SUMMARY THIRD COAST CFAR: OVERALL The broad, long-term mission of the Third Coast Center for AIDS Research (TC CFAR) is to use our trans-disciplinary collaborations to power transformational advances across the translational spectrum from discovery to implementation of effective interventions - and end HIV. Many local resources at Northwestern University (UC), the University of Chicago (UC), and community partners have been, and will continue to be, brought to bear on this mission. The allowable Funded Research Base (FRB) increased by 47%, and projects became more trans-disciplinary, from FY14 to FY18. Nimble and opportunistic strategic planning (by the Administrative Core, AC) and robust growth in seed funding and mentoring programs (by the Developmental Core, DC) led to those successes, and to choosing specific, high-priority HIV research topics as foci for a second term. Institutional support has increased. The Overall scientific aims were also chosen based on each of the 3 scientific Cores having a user base and expert resources with strengths on each aim. Each of these Cores has also worked to extend their resources and expertise to researchers outside their own domains, and thereby helped build collaborations. The following Overall aims build on our solid foundation, and will direct each scientific Core, in concert with the AC and the DC, to synergistically advance the science needed to end HIV. Overall Aim 1: To continue and expand collaborative research that will slow, and eventually stop, the HIV epidemic by improving continuums of HIV prevention and care. Overall Aim 2: To advance understanding of accelerated aging-related illnesses (non-AIDS comorbidities) that occur despite suppression of HIV viremia. Overall Aim 3: To speed discovery and empower development of transformative scientific innovations that will improve HIV prevention and treatment for persons living with HIV.

项目摘要 第三海岸CFAR：总体 第三海岸艾滋病研究中心（TC CFAR）的长期长期任务是使用我们 跨学科的合作，以跨翻译光谱的权力转型进步 从发现到实施有效的干预措施，再到结束艾滋病毒。许多本地资源 西北大学（UC），芝加哥大学（UC）和社区合作伙伴已经存在，并且 将继续进行这项任务。允许资助的研究基础（FRB） 从2014财年到2018财年，项目增加了47％，项目变得更加跨学科。敏捷和 机会主义战略计划（通过行政核心，AC）和种子资金的强劲增长 和指导计划（通过发展核心，DC）导致了这些成功，并选择了 特定的，高优先级的HIV研究主题是第二任期的焦点。机构支持有所增加。 总体科学目的还根据具有用户的3个科学核心选择 基础和专家资源都具有每个目标的优势。这些核心也都努力扩展 他们对自己领域之外的研究人员的资源和专业知识，从而帮助建立了 协作。以下总体目标建立在我们的坚实基础上，并将指导每个科学 核心与AC和DC一致，以协同促进结束艾滋病毒所需的科学。 总体目的1：继续并扩大协作研究，这将放缓，最终停止， 通过改善艾滋病毒预防和护理的连续性，艾滋病毒流行。 总体目标2：提高对加速与衰老相关疾病的了解（非AIDS 尽管抑制了HIV病毒血症，但发生的合并症）。 总体目标3：加快发现并增强变革性科学创新的能力 这将改善艾滋病毒患者的艾滋病毒预防和治疗。