Synergistic effect of maternal insulin-resistance and cortisol in pregnancy on fetal programming of child mitochondrial function and obesity risk

妊娠期母体胰岛素抵抗和皮质醇对胎儿线粒体功能和肥胖风险的协同作用

• 批准号: 10406103
• 负责人: Lauren Elizabeth Gyllenhammer
• 金额: $ 5.07万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10406103
• 关键词: Abdomen; Address; Adipose tissue; Age; Animals; Area Under Curve; Biological; Biological Products; Birth; Body Composition; Body fat; Body mass index; Cell Culture Techniques; Cells; Child; Childhood; Citrate (si)-Synthase; Cross-Over Studies; Crossover Design; DNA copy number; Data; Development; Drug or chemical Tissue Distribution; Dual-Energy X-Ray Absorptiometry; Enrollment; Ensure; Exposure to; Fasting; Fatty acid glycerol esters; Funding; Gestational Age; Glucose; Health; Hepatic; Homeostasis; Hormones; Human; Hydrocortisone; Image; Individual; Individual Differences; Infant; Insulin; Insulin Resistance; Intra-abdominal; Knowledge; Late pregnancy; Maternal Age; Measures; Mediating; Mediator of activation protein; Metabolic dysfunction; Metabolic stress; Methods; Mitochondria; Mitochondrial DNA; Modeling; Mothers; Newborn Infant; Nuclear; OGTT; Obesity; Observational Study; Outcome; Pathogenesis; Peripheral Blood Mononuclear Cell; Phase; Physiology; Predisposition; Pregnancy; Pregnant Women; Production; Public Health; Randomized; Research Design; Respiratory Chain; Role; Salivary; Shapes; Standardization; Statistical Models; Stratification; Stress; Subcutaneous Tissue; Testing; Time; Treatment Efficacy; Trier Social Stress Test; Umbilical Cord Blood; United States National Institutes of Health; Weight; acute stress; base; cohort; design; fasting glucose; fetal; fetal programming; in utero; in vivo; indexing; infancy; infant adiposity; maternal stress; novel; obesity in children; obesity risk; offspring; population based; postnatal; prenatal; prenatal exposure; prepregnancy; prospective; response; sex; stress reduction; subcutaneous

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