Impact of COVID-19 on disinfectant exposure and associated health effects.

COVID-19 对消毒剂接触和相关健康影响的影响。

基本信息

批准号：
10400556
负责人：
Soo-Jeong Lee
金额：
$ 24.23万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-10 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10400556
关键词：
2019-nCoV Address Affect Age Allergic Ammonium Chloride Animals Area Asthma Bacterial Artificial Chromosomes Benzalkonium Chloride Biological Biological Markers Biological Monitoring Blood Body Burden COVID-19 COVID-19 pandemic California Cells Characteristics Chemicals Chinese People Cholesterol Communities Community Health Community Workers Data Data Sources Detection Disinfectants Disinfection Epidemiology Excretory function Exposure to Eye Feces Foundations Future Gender General Population Hazardous Chemicals Health Health Personnel Health system Hispanics Home Hospitals Human Incidence Infection Control Infection prevention Inflammation Link Measurement Measures Mitochondria National Institute of Environmental Health Sciences Nervous system structure Occupational Occupational Exposure Occupational Groups Occupations Organ Participant Patient Self-Report Perception Pesticides Pilot Projects Poison Policies Population Public Health Pulmonary Inflammation Rattus Reporting Reproduction Research Respiratory System Risk Route SARS-CoV-2 infection Sampling Skin Surface Surveillance Program Surveys Symptoms Time Universities Urine Workplace base comorbidity experience exposed human population follow-up health care settings healthy volunteer high risk population immune function improved irritation microorganism novel strategies pandemic disease pathogen prevent preventive intervention quaternary ammonium compound response substance use surveillance study transmission process trend

项目摘要

PROJECT SUMMARY/ABSTRACT Disinfectants are widely used in various products and in various settings to prevent infection and transmission of harmful pathogens. Disinfectants, however, contain hazardous chemicals and are known to cause irritation or allergic symptoms in eyes, skin, respiratory and nervous systems, asthma, and damage to organs with prolonged or repeated exposure. Quaternary ammonium compounds (QACs) are the most common active ingredients used in disinfectants approved for SARS-CoV-2 control. The coronavirus disease 2019 (COVID-19) pandemic led to dramatically increased use of disinfectants in the community and workplaces to prevent SARS-CoV-2 infection and transmission. Such increased use of disinfectants raises substantial concerns regarding the health effects of disinfectants. As for health risk by disinfectants, cleaning workers, particularly in healthcare settings, have been identified as occupational groups most affected by disinfectants. During the COVID-19 pandemic, with the heightened need for infection control in healthcare settings as well as increased use of disinfectants at home/community, these workers may have further increased health risks from disinfectant exposure. The purpose of this study is to assess the impact of the COVID-19 pandemic on disinfectant use and the incidence of disinfectant-related illness and examine the association between disinfectant exposure and health symptoms. We propose a study using three approaches: (1) Analysis of California Pesticide Illness Surveillance Program data (2011-2020) to investigate disinfectant-related illness cases in California. (2) A survey of 300 cleaning staff (predominantly Chinese and Hispanic) in a university health system in Northern California on disinfectant use and chemical-related health symptoms. (3) Measurement of two common QACs (benzalkonium chloride [BAC] and didecyl dimethyl ammonium chloride [DDAC]) in feces and urine in a subset of survey participants (n=100). The study has the following specific aims: (1) Characterize disinfectant-related illness cases in California during 2011-2020 and examine the trend of the annual incidence over time. (2) Characterize disinfectant use during COVID-19 among hospital cleaning staff and examine the relationship of disinfectant use with self-reported health symptoms. (3) Measure QACs (BAC/DDAC) in feces and urine among hospital cleaning staff and examine their associations with self- reported disinfectant use and health symptoms. This study will produce helpful information to assess the public health burden by the widely used disinfectants and the impact of COVID-19 on disinfectant exposure and health problems among the general population as well as the high-risk group of hospital cleaning staff. This study will be one of the first studies that measures and quantifies QACs in human samples to examine health effects. The biological data on QAC exposure among hospital cleaning staff will capture the body burden of disinfectant chemicals from both occupational and non-occupational exposures that increased during the COVID-19 pandemic, and will serve as a valuable foundation for analyses of longer-term health effects.

项目概要/摘要消毒剂广泛用于各种产品和各种环境中，以防止感染和传播有害病原体。然而，消毒剂含有危险化学物质，会引起刺激或眼睛、皮肤、呼吸和神经系统过敏症状、哮喘以及器官损伤长时间或反复接触。季铵化合物 (QAC) 是最常见的活性物质批准用于控制 SARS-CoV-2 的消毒剂中使用的成分。 2019 年冠状病毒病 (COVID-19) 大流行导致社区和工作场所消毒剂的使用急剧增加，以预防 SARS-CoV-2 感染和传播。消毒剂使用的增加引起了人们的严重担忧关于消毒剂对健康的影响。至于消毒剂、清洁工，尤其是清洁工的健康风险医疗机构已被确定为受消毒剂影响最严重的职业群体。期间 COVID-19 大流行，医疗机构中感染控制的需求日益增加，如果在家/社区使用消毒剂，这些工人可能会进一步增加健康风险消毒剂暴露。本研究的目的是评估 COVID-19 大流行对消毒剂的使用和消毒剂相关疾病的发生率，并检查两者之间的关联消毒剂暴露和健康症状。我们提出一项使用三种方法的研究：（1）分析用于调查消毒剂相关疾病的加州农药疾病监测计划数据（2011-2020 年）加利福尼亚州的病例。 (2) 对某大学300名保洁人员（主要是华人和西班牙裔）的调查北加州卫生系统有关消毒剂使用和化学品相关健康症状的信息。 (3) 两种常见 QAC（苯扎氯铵 [BAC] 和二癸基二甲基氯化铵）的测量 [DDAC]）存在于一部分调查参与者（n=100）的粪便和尿液中。该研究有以下具体内容目标：(1) 描述 2011-2020 年加州与消毒剂相关的疾病病例特征并研究趋势随时间变化的年发病率。 (2) 描述 COVID-19 期间医院清洁中消毒剂使用的特点工作人员并检查消毒剂使用与自我报告的健康症状的关系。 (3) 测量 QAC (BAC/DDAC) 存在于医院清洁人员的粪便和尿液中，并检查其与自我报告了消毒剂的使用和健康症状。这项研究将产生有用的信息来评估公众广泛使用的消毒剂造成的健康负担以及 COVID-19 对消毒剂接触和影响的影响普通人群以及医院清洁人员的高危人群的健康问题。这该研究将是首批测量和量化人体样本中的 QAC 以检查健康状况的研究之一影响。医院清洁人员 QAC 暴露的生物数据将反映患者的身体负担职业和非职业接触的消毒化学品在 COVID-19 大流行，并将成为分析长期健康影响的宝贵基础。