Impact of COVID-19 on disinfectant exposure and associated health effects.

COVID-19 对消毒剂接触和相关健康影响的影响。

• 批准号: 10400556
• 负责人: Soo-Jeong Lee
• 金额: $ 24.23万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10400556
• 关键词: 2019-nCoV; Address; Affect; Age; Allergic; Ammonium Chloride; Animals; Area; Asthma; Bacterial Artificial Chromosomes; Benzalkonium Chloride; Biological; Biological Markers; Biological Monitoring; Blood; Body Burden; COVID-19; COVID-19 pandemic; California; Cells; Characteristics; Chemicals; Chinese People; Cholesterol; Communities; Community Health; Community Workers; Data; Data Sources; Detection; Disinfectants; Disinfection; Epidemiology; Excretory function; Exposure to; Eye; Feces; Foundations; Future; Gender; General Population; Hazardous Chemicals; Health; Health Personnel; Health system; Hispanics; Home; Hospitals; Human; Incidence; Infection Control; Infection prevention; Inflammation; Link; Measurement; Measures; Mitochondria; National Institute of Environmental Health Sciences; Nervous system structure; Occupational; Occupational Exposure; Occupational Groups; Occupations; Organ; Participant; Patient Self-Report; Perception; Pesticides; Pilot Projects; Poison; Policies; Population; Public Health; Pulmonary Inflammation; Rattus; Reporting; Reproduction; Research; Respiratory System; Risk; Route; SARS-CoV-2 infection; Sampling; Skin; Surface; Surveillance Program; Surveys; Symptoms; Time; Universities; Urine; Workplace; base; comorbidity; experience; exposed human population; follow-up; health care settings; healthy volunteer; high risk population; immune function; improved; irritation; microorganism; novel strategies; pandemic disease; pathogen; prevent; preventive intervention; quaternary ammonium compound; response; substance use; surveillance study; transmission process; trend

PROJECT SUMMARY/ABSTRACT Disinfectants are widely used in various products and in various settings to prevent infection and transmission of harmful pathogens. Disinfectants, however, contain hazardous chemicals and are known to cause irritation or allergic symptoms in eyes, skin, respiratory and nervous systems, asthma, and damage to organs with prolonged or repeated exposure. Quaternary ammonium compounds (QACs) are the most common active ingredients used in disinfectants approved for SARS-CoV-2 control. The coronavirus disease 2019 (COVID-19) pandemic led to dramatically increased use of disinfectants in the community and workplaces to prevent SARS-CoV-2 infection and transmission. Such increased use of disinfectants raises substantial concerns regarding the health effects of disinfectants. As for health risk by disinfectants, cleaning workers, particularly in healthcare settings, have been identified as occupational groups most affected by disinfectants. During the COVID-19 pandemic, with the heightened need for infection control in healthcare settings as well as increased use of disinfectants at home/community, these workers may have further increased health risks from disinfectant exposure. The purpose of this study is to assess the impact of the COVID-19 pandemic on disinfectant use and the incidence of disinfectant-related illness and examine the association between disinfectant exposure and health symptoms. We propose a study using three approaches: (1) Analysis of California Pesticide Illness Surveillance Program data (2011-2020) to investigate disinfectant-related illness cases in California. (2) A survey of 300 cleaning staff (predominantly Chinese and Hispanic) in a university health system in Northern California on disinfectant use and chemical-related health symptoms. (3) Measurement of two common QACs (benzalkonium chloride [BAC] and didecyl dimethyl ammonium chloride [DDAC]) in feces and urine in a subset of survey participants (n=100). The study has the following specific aims: (1) Characterize disinfectant-related illness cases in California during 2011-2020 and examine the trend of the annual incidence over time. (2) Characterize disinfectant use during COVID-19 among hospital cleaning staff and examine the relationship of disinfectant use with self-reported health symptoms. (3) Measure QACs (BAC/DDAC) in feces and urine among hospital cleaning staff and examine their associations with self- reported disinfectant use and health symptoms. This study will produce helpful information to assess the public health burden by the widely used disinfectants and the impact of COVID-19 on disinfectant exposure and health problems among the general population as well as the high-risk group of hospital cleaning staff. This study will be one of the first studies that measures and quantifies QACs in human samples to examine health effects. The biological data on QAC exposure among hospital cleaning staff will capture the body burden of disinfectant chemicals from both occupational and non-occupational exposures that increased during the COVID-19 pandemic, and will serve as a valuable foundation for analyses of longer-term health effects.

项目摘要/摘要 消毒剂被广泛用于各种产品和各种环境中，以防止感染和传播 有害病原体。但是，消毒剂含有危险化学物质，已知会引起刺激 或眼睛，皮肤，呼吸系统和神经系统，哮喘以及对器官的症状或过敏性症状 长时间或反复的暴露。第四纪铵化合物（QAC）是最常见的活性 用于SARS-COV-2控制的消毒剂中使用的成分。 2019年冠状病毒病（COVID-19） 大流行导致社区和工作场所中消毒剂的使用大大增加，以防止 SARS-COV-2感染和传播。这种消毒剂的使用增加引起了实质性的关注 关于消毒剂的健康影响。至于消毒剂，清洁工人的健康风险，特别是 医疗保健环境已被确定为受消毒剂影响最大的职业群体。在 COVID-19大流行，在医疗保健环境中对感染控制的需求增强，并增加 在家庭/社区中使用消毒剂，这些工人可能会进一步增加健康风险 消毒剂暴露。这项研究的目的是评估COVID-19大流行对 消毒剂的使用和与消毒相关疾病的发生率，并检查 消毒剂暴露和健康症状。我们建议使用三种方法进行研究：（1）分析 加利福尼亚农药疾病监视计划（2011-2020）调查与消毒有关的疾病 加利福尼亚的案件。 （2）一所大学的300名清洁人员（主要是中国人和西班牙裔）的调查 加利福尼亚北部的卫生系统因消毒和化学相关的健康症状而进行。 （3） 测量两个常见的QAC（氯化苯甲酸盐[BAC]和二甲基二甲基氯化铵 [DDAC]）在粪便和尿液中的一部分中（n = 100）。该研究具有以下特定 目的：（1）特征在2011 - 2020年在加利福尼亚州与消毒剂相关的疾病病例进行表征并检查趋势 随着时间的流逝的年度发病率。 （2）在医院清洁中，在Covid-19期间的消毒剂使用表征 员工并检查使用消毒剂的使用与自我报告的健康症状的关系。 （3）测量QAC （BAC/DDAC）在医院清洁人员中的粪便和尿液中 报告了消毒剂使用和健康症状。这项研究将产生有用的信息来评估公众 广泛使用的消毒剂以及Covid-19对消毒剂暴露和 普通人群以及高危医院清洁人员的健康问题。这 研究将是测量和量化人类样本中QAC以检查健康的第一批研究之一 效果。医院清洁人员中QAC暴露的生物数据将捕获身体负担 对职业和非职业暴露的消毒化学物质在 Covid-19-19大流行，并将成为分析长期健康影响的宝贵基础。