The Role of Extracellular Environment in Adipocyte Fate

细胞外环境在脂肪细胞命运中的作用

基本信息

批准号：
10395482
负责人：
Maria Alejandra Gonzalez Porras
金额：
$ 7.64万
依托单位：
UNIVERSITY OF TEXAS SAN ANTONIO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-01 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10395482
关键词：
3-Dimensional Adhesions Adipocytes Adipose tissue American Biochemical Biocompatible Materials Biomedical Engineering Cardiovascular Diseases Cell Communication Cells Characteristics Chronic Collagen Communication Data Disease Energy Intake Energy Metabolism Environment Environmental Risk Factor Event Exhibits Extracellular Matrix Fatty acid glycerol esters Fiber Genes Goals Healthcare Homeostasis Human Hypertrophy Insulin Resistance Integrins Knock-out Knowledge Laboratories Laminin Lipids Maintenance Mammals Mechanics Mediating Medical Mentors Metabolic Metabolic Diseases Mitochondria Morbidity - disease rate Mus Non-Insulin-Dependent Diabetes Mellitus Obesity Obesity Epidemic Organ Outcome Pathologic Physiological Physiology Play Population Preparation Property Proteins Proteoglycan Public Health Research Resistance Role Signal Transduction Structure System Therapeutic Thermogenesis Tissues Wild Type Mouse Work Writing base blood glucose regulation career career development cell behavior experience extracellular fibrous protein improved in vivo insight insulin sensitivity interstitial mechanical properties mechanotransduction mortality nanoparticle new therapeutic target novel null mutation skills stem cells subcutaneous targeted delivery therapeutic development therapeutic target uncoupling protein 1

项目摘要

Project Summary Obesity, a chronic imbalance in energy homeostasis between energy intake and energy expenditure, is a public health crisis and continues to be among the most important medical challenges in the U.S.A. Obesity creates a greater than $190 billion burden annually on American healthcare. The development of therapeutic approaches that lessen or eliminate obesity-associated morbidity and mortality would have a transformative impact on the American population and healthcare spending. There are two types of adipose tissue in mammals: white adipose tissue which is specialized for energy storage, and thermogenic adipose tissue specialized for energy expenditure and thermogenesis. Thermogenic adipose tissue has been shown to have an inverse correlation with adiposity, meaning that it might be possible to increase whole-body energy expenditure by increasing the number and/or activity of thermogenic adipose tissue. Thus, altering adipose thermogenic capacity could be a treatment for metabolic diseases, including obesity. New therapies targeting thermogenic adipose tissue have failed in maintaining transformed adipose tissue in-vivo, in part, due to the limited understanding of how environmental factors control adipocyte fate and maintenance. This research effort aims to understand the role of the extracellular matrix interaction (ECM) in the fate of adipocytes. This information will identify new therapeutic targets for obesity and metabolic diseases. A better understanding of the underlying causes of these characteristics for thermogenic fat will allow us to specifically manipulate these cells to improve systemic energy metabolism and glucose homeostasis, and to explore synthetic substrates that increase formation of thermogenic adipose tissue.

项目概要肥胖是能量摄入和能量消耗之间能量稳态的长期不平衡，是一个公共问题健康危机，并且仍然是美国最重要的医疗挑战之一。肥胖造成了每年给美国医疗保健带来超过 1900 亿美元的负担。治疗方法的发展减少或消除与肥胖相关的发病率和死亡率将对美国人口和医疗保健支出。哺乳动物有两种类型的脂肪组织：白色脂肪专门用于能量储存的组织和专门用于能量的产热脂肪组织支出和产热作用。产热脂肪组织已被证明具有负相关性与肥胖有关，这意味着可以通过增加产热脂肪组织的数量和/或活性。因此，改变脂肪产热能力可能是一个治疗代谢性疾病，包括肥胖症。针对产热脂肪组织的新疗法未能在体内维持转化的脂肪组织，部分原因是对如何维持转化的脂肪组织的了解有限环境因素控制脂肪细胞的命运和维持。这项研究工作旨在了解这一角色细胞外基质相互作用（ECM）对脂肪细胞命运的影响。该信息将确定新的治疗方法肥胖和代谢疾病的目标。更好地了解这些问题的根本原因产热脂肪的特性将使我们能够专门操纵这些细胞来提高全身能量代谢和葡萄糖稳态，并探索增加形成的合成底物产热脂肪组织。

项目成果

期刊论文数量（1）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Integrins and extracellular matrix proteins modulate adipocyte thermogenic capacity.

DOI：
10.1038/s41598-021-84828-z
发表时间：
2021-03-08
期刊：
Scientific reports
影响因子：
4.6
作者：
Gonzalez Porras MA;Stojkova K;Vaicik MK;Pelowe A;Goddi A;Carmona A;Long B;Qutub AA;Gonzalez A;Cohen RN;Brey EM
通讯作者：
Brey EM