Systems Pharmacology and Toxicology Training Program

系统药理学和毒理学培训计划

基本信息

批准号：
10394415
负责人：
Paul L Prather
金额：
$ 16.82万
依托单位：
UNIV OF ARKANSAS FOR MED SCIS
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10394415
关键词：
Pharmacology and Toxicology System Training Programs

项目摘要

Project Summary/Abstract: Over the past few decades, our knowledge of the mechanisms by which cells interact with drugs and toxins has exploded due to new molecular analysis techniques and the application of genomic methods. Accordingly, the emphasis of graduate education in the disciplines of pharmacology and toxicology needs to shift from a reductionist view to a systems approach in which doctoral students are comprehensively trained so they can formulate a strategy to solve important biological questions not only at the molecular, cellular, and tissue levels but also at the whole-animal level. Systems pharmacology and toxicology describes a field of study that considers the broad view of drug action. A systems approach using in vivo animal models is necessary to establish efficacy, safety and the pharmacodynamic/pharmacokinetic profile of candidate drugs but there is a shortage of students trained in this area. This Systems Pharmacology and Toxicology (SPaT) Program is designed for PhD students in their second year of graduate study pursuing dissertation research projects in the pharmacological sciences. Trainees (2/year for up to 2 years of support) and training faculty (30 mentors and 4 teachers) are drawn from the Graduate Program in Interdisciplinary Biomedical Sciences and the MD/PhD Program. The SPaT program will train students to use an in vivo approach to answering relevant questions in pharmacology and toxicology with emphasis on metabolism, drug design, pharmacodynamics, pharmacokinetics, and signaling. The rationale for SPaT is that this type of training provides students with a much broader perspective on pharmacology and toxicology that better prepares them to be leaders of multi-disciplinary research teams in the pharmacological sciences. We will integrate SPaT into PhD training programs already active at our graduate training sites in the Little Rock area that include faculty/scientists in the Colleges of Medicine, Pharmacy, and Public Health on the UAMS, the Arkansas Children's Hospital campus, and at the Food and Drug Administration-funded National Center for Toxicological Research. The unique focus of SPaT is training with in vivo systems pharmacological and toxicological approaches and concepts. The objective of SPaT is to provide in vivo pharmacology and toxicology training that complement the cellular and molecular training that students receive in their home programs. The training program consists of didactic training in pharmacology, toxicology, physiology, pharmacokinetics, metabolism, biostatistics, grant writing, and the Responsible Conduct of Research along with laboratory research using an in vivo model of human disease. The SPaT program will also provide strong mentoring, extensive networking, and teaching and leadership opportunities for its trainees through its programmatic activities.

项目摘要/摘要：在过去的几十年中，我们对细胞与药物和毒素相互作用的机制的了解由于新的分子分析技术和基因组方法的应用而爆炸。因此，强调药理学学科和毒理学学科的研究生教育需要从还原主义者对一种系统方法的看法，在该系统方法中，博士生接受了全面培训，以便他们可以制定一种策略，不仅在分子，细胞和组织水平上解决重要的生物学问题而且还处于整个动物级别。系统药理学和毒理学描述了考虑的研究领域毒品作用的广泛观点。使用体内动物模型的系统方法对于建立功效是必要的候选药物的安全性和药效/药代动力学特征，但学生短缺在这个地区训练。该系统药理学和毒理学（SPAT）计划是为博士生设计的在研究生研究的第二年，从事药理学的论文研究项目。学员（最多2年的2年支持）和培训教师（30名导师和4名老师）跨学科生物医学科学和MD/PHD计划的研究生课程。吵架程序将培训学生使用体内方法来回答药理学和毒理学方面的相关问题重点是代谢，药物设计，药效学，药代动力学和信号传导。理由吐口水的是，这种类型的培训为学生提供了有关药理学和更好地使他们成为药理学多学科研究团队的领导者的毒理学科学。我们将把Spat集成到已经在我们的研究生培训网站上活跃的博士学位培训计划中小岩石地区包括医学，药房和公共卫生学院的教师/科学家 UAMS，阿肯色州儿童医院校园，以及在食品和药物管理局资助的国家毒理学研究中心。吐口水的独特重点是体内系统药理训练以及毒理学方法和概念。争论的目的是提供体内药理学和毒理学培训补充了学生在家中接受的细胞和分子训练程序。培训计划包括药理学，毒理学，生理学的教学培训，药代动力学，代谢，生物统计学，赠款写作以及负责任的研究进行实验室研究使用人体疾病的体内模型。吵架计划还将提供强大的通过其学员的指导，广泛的网络以及教学和领导机会编程活动。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Renal cold storage followed by transplantation impairs expression of key mitochondrial fission and fusion proteins.

DOI：
10.1371/journal.pone.0185542
发表时间：
2017
期刊：
PloS one
影响因子：
3.7
作者：
Parajuli N;Shrum S;Tobacyk J;Harb A;Arthur JM;MacMillan-Crow LA
通讯作者：
MacMillan-Crow LA

Expression of drug metabolizing enzymes and transporters in the cochlea: Implications for drug delivery and ototoxicity.

耳蜗中药物代谢酶和转运蛋白的表达：对药物输送和耳毒性的影响。

DOI：
10.1016/j.heares.2019.05.002
发表时间：
2019
期刊：
Hearing research
影响因子：
2.8
作者：
Kennon-McGill,Stefanie;Clemens,MelissaM;McGill,MitchellR
通讯作者：
McGill,MitchellR

Redrawing the map to novel DILI biomarkers in circulation: Where are we, where should we go, and how can we get there?

DOI：
10.3390/livers1040022
发表时间：
2021-12
期刊：
Livers
影响因子：
0
作者：
Vazquez JH;McGill MR
通讯作者：
McGill MR

Overexpression of MnSOD Protects against Cold Storage-Induced Mitochondrial Injury but Not against OMA1-Dependent OPA1 Proteolytic Processing in Rat Renal Proximal Tubular Cells.

DOI：
10.3390/antiox10081272
发表时间：
2021-08-11
期刊：
Antioxidants (Basel, Switzerland)
影响因子：
0
作者：
Tobacyk J;Kc G;MacMillan-Crow LA
通讯作者：
MacMillan-Crow LA

The link between immunity and hypertension in the kidney and heart.

DOI：
10.3389/fcvm.2023.1129384
发表时间：
2023
期刊：
FRONTIERS IN CARDIOVASCULAR MEDICINE
影响因子：
3.6
作者：
Benson, Lance N.;Guo, Yunping;Deck, Katherine;Mora, Christoph;Liu, Yunmeng;Mu, Shengyu
通讯作者：
Mu, Shengyu