Integrative Data Analysis of Coping Power: Effects on Adolescent Suicidality

应对能力的综合数据分析：对青少年自杀的影响

• 批准号: 10394921
• 负责人: JOHN E LOCHMAN
• 金额: $ 49.71万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10394921
• 关键词: Accounting; Address; Adolescence; Adolescent; Aggressive behavior; Area; Behavior; Cause of Death; Characteristics; Child; Childhood; Data; Data Analyses; Development; Discipline; Exhibits; Factor Analysis; Family; Gender; Human; Individual; Internet; Intervention; Life; Literature; Measurement; Measures; Mediator of activation protein; Meta-Analysis; Modeling; Outcome; Pathway interactions; Patient-Focused Outcomes; Population; Population Intervention; Prevention; Prevention approach; Preventive; Psychopathology; Randomized; Randomized Controlled Trials; Reporter; Research Personnel; Risk; Risk Factors; School-Age Population; Schools; Specificity; Suicide; Suicide attempt; Suicide prevention; Symptoms; Testing; Time; Variant; Weight; Youth; aged; boys; comparative; coping; critical period; emotion regulation; girls; high school; individual patient; innovation; intervention effect; novel; post intervention; preventive intervention; programs; response; substance use; suicidal behavior; suicidal morbidity; suicidal risk; suicide rate; theories; young adult

PROJECT SUMMARY/ABSTRACT Suicide is the second leading cause of death among individuals aged 10-34 in the US, with 17% of high school-aged youth seriously considering a suicide attempt and 8% attempting suicide. There is emerging evidence to suggest that preventive interventions that do not explicitly target suicide have “crossover” effects on suicidality. However, the majority of interventions that have been examined for their impact on suicide target internalizing behaviors, which may miss a significant subset of boys, whose risk for suicidality is primarily transmitted through externalizing; this concern is echoed by calls in the recent suicide prevention literature for addressing the dearth of literature on suicide crossover effects from externalizing-focused interventions. The Coping Power (CP) program is an empirically supported, child- and family-focused preventive intervention that focuses on reducing externalizing more broadly among youth who exhibit early aggression, which makes it ideally suited to addressing the above-mentioned gaps in targeting externalizing pathways to suicidality. The proposed study will combine data from 10 randomized controlled trials (RCTs) of CP (total individual-level N = 3,201; total school-level N = 188) and utilize three measurement and data analysis frameworks that have emerged across multiple independent disciplines: integrative data analysis (IDA), meta- analysis of individual patient data (MIPD), and propensity score weighting (PSW). Using these frameworks, we propose the following aims: Aim 1: Estimate scale scores for key constructs while accounting for differential item functioning across studies, time, populations, and reporters. Aim 2: Assess comparative effect sizes for multiple forms of Coping Power (CP) using IDA-estimated scale scores for CP mechanisms of action, externalizing, internalizing, and suicidality. Aim 3: Test for potential mediators of CP effects on risk for suicidality as transmitted through CP's mechanisms of action (MoAs) and/or intermediate endpoints. Aim 4: Explore individual-, school- and study-level moderators of CP's effects on MoAs, intermediate endpoints, and risk for suicidality. If successful, the proposed study will (1) be one of the first to apply a symptom weighting framework (e.g., MNLFA, item response theory) for measuring suicidality, while accounting for measurement bias across multiple factors (e.g., time, development, demographic variables, reporters), (2) provide initial evidence for preventive effects on suicidality through gender-specific pathways (externalizing for boys, internalizing for girls), (3) illustrate evidence that CP's direct and/or indirect impact on reductions in suicidality is greater among youth who are at higher initial risk, and (4) identify the optimal conditions for CP delivery (e.g., group, individual, internet) for different youth characteristics (which could not be examined in any single RCT of CP).

项目摘要/摘要 自杀是美国10-34岁个个人的第二大死亡原因，高17％ 学龄的青年认真考虑自杀企图，并尝试自杀8％。有新兴 有证据表明，不明确靶向自杀的预防性干预措施具有“交叉”影响 关于自杀性。但是，大多数已对其对自杀目标的影响进行了检查的干预措施 内在化行为可能会错过大量男孩的子集，他们的自杀风险是主要的 通过外部化传播；最近的自杀预防文献中的呼吁与 解决文献对以外部化干预措施的自杀跨界影响的死亡。 应对能力（CP）计划是一项经验支持，以儿童和家庭为中心的预防性 干预措施着重于在暴露早期侵略性的青年中更广泛地降低外在化的干预措施 这使其理想地适合于针对外在途径到达上述差距 自杀性。拟议的研究将结合10个随机对照试验（RCT）的数据（总计 个人级别n = 3,201;总学校级别n = 188）并使用三个测量和数据分析 跨多个独立学科出现的框架：综合数据分析（IDA），meta- 分析单个患者数据（MIPD）和改进评分加权（PSW）。使用这些框架，我们 提案以下目的： AIM 1：估算关键结构的量表得分，同时考虑差异项目功能 在研究，时间，人群和记者之间。 AIM 2：使用IDA估算 CP动作，外在化，内在化和自动化的量表得分。 AIM 3：测试通过CP传播的CP潜在介体对自杀风险的影响 作用机理（MOA）和/或中间端点。 目标4：探索CP对MOAS的影响的个人，学校和学习级别的主持人 终点和自杀的风险。 如果成功，拟议的研究将（1）是最早采用症状加权框架的研究之一（例如， MNLFA，项目响应理论）用于测量自杀性，同时考虑到跨越测量的偏见 多种因素（例如时间，发展，人口统计学变量，记者），（2）提供初始证据 通过性别特异性途径对自杀的预防作用（男孩外部化，内在化 女孩），（3）说明CP对自杀减少的直接和/或间接影响的证据更大 面临较高初始风险的年轻人，（4）确定CP交付的最佳条件（例如，组， 个人，Internet）具有不同的青年特征（在CP的任何单个RCT中都无法检查。