Impact of Delayed Onset Muscle Soreness on Demand for Alcohol and Marijuana among Co-Users

延迟性肌肉酸痛对共同使用者对酒精和大麻需求的影响

• 批准号: 10394130
• 负责人: Erin Ferguson
• 金额: $ 1.58万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-16 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10394130
• 关键词: Absence of pain sensation; Acute Pain; Address; Alcohol abuse; Alcohol consumption; Alcohols; Analgesics; Anger; Anxiety; Area; Behavior; Behavioral; Consumption; Control Groups; Coping Skills; Data; Development; Distress; Doctor of Philosophy; Economic Burden; Elbow; Environment; Exercise; Expectancy; Flexor; Frustration; General Population; Goals; Health behavior; Individual; Intention; Intervention; Knowledge; Lead; Marijuana; Measures; Mediating; Medical Marijuana; Mentors; Methods; Muscle; Musculoskeletal Pain; Neuropharmacology; Observational Study; Pain; Pain management; Participant; Pattern; Prevalence; Price; Psychometrics; Psychosocial Factor; Race; Recording of previous events; Reporting; Research; Resources; Risk; Risk Factors; Self Medication; Severities; Sex Differences; Substance Use Disorder; Testing; Time; Training; Translating; Woman; Work; adverse outcome; alcohol demand; alcohol risk; alcohol use disorder; behavioral economic analysis; behavioral economics; biopsychosocial; black men; black women; chronic pain; clinical pain; clinically relevant; cost efficient; craving; epidemiology study; experience; experimental study; follow-up; functional disability; high risk; improved; marijuana use; marijuana use disorder; marijuana user; men; negative affect; novel; pain patient; pain self-management; programs; psychosocial; racial difference; sex; skill acquisition; social; substance use; Absence of pain sensation; Acute Pain; Address; Alcohol abuse; Alcohol consumption; Alcohols; Analgesics; Anger; Anxiety; Area; Behavior; Behavioral; Consumption; Control Groups; Coping Skills; Data; Development; Distress; Doctor of Philosophy; Economic Burden; Elbow; Environment; Exercise; Expectancy; Flexor; Frustration; General Population; Goals; Health behavior; Individual; Intention; Intervention; Knowledge; Lead; Marijuana; Measures; Mediating; Medical Marijuana; Mentors; Methods; Muscle; Musculoskeletal Pain; Neuropharmacology; Observational Study; Pain; Pain management; Participant; Pattern; Prevalence; Price; Psychometrics; Psychosocial Factor; Race; Recording of previous events; Reporting; Research; Resources; Risk; Risk Factors; Self Medication; Severities; Sex Differences; Substance Use Disorder; Testing; Time; Training; Translating; Woman; Work; adverse outcome; alcohol demand; alcohol risk; alcohol use disorder; behavioral economic analysis; behavioral economics; biopsychosocial; black men; black women; chronic pain; clinical pain; clinically relevant; cost efficient; craving; epidemiology study; experience; experimental study; follow-up; functional disability; high risk; improved; marijuana use; marijuana use disorder; marijuana user; men; negative affect; novel; pain patient; pain self-management; programs; psychosocial; racial difference; sex; skill acquisition; social; substance use

Project Summary/Abstract The overall goal of this proposal is to advance knowledge about pain as a determinant of substance use, particularly alcohol and marijuana use. A substantial body of research indicates that self-medication of pain with alcohol and marijuana (i.e. use to cope with and/or manage pain) is common among pain patients, and epidemiological and observational studies suggest that pain can act as a potent motivator of substance use. Initial experimental evidence suggests that pain can increase urge and intention to consume alcohol, yet this relationship has not been replicated using clinically-relevant pain induction methods with greater ecological validity than typical experimental pain approaches. Further, despite similar pain-inhibitory effects and co- occurring use patterns of alcohol and marijuana, current research has not simultaneously examined the proximal effects of pain on alcohol and marijuana use. Thus, the proposed work will attempt to determine whether experimentally-induced musculoskeletal pain (i.e., delayed onset muscle soreness; DOMS) may increase alcohol and marijuana demand among co-users. An experimental study will be conducted, during which regular co-users of marijuana and alcohol will be assigned to either a DOMS (high-intensity eccentric exercise) or sham DOMS control condition (low-intensity concentric exercise). Overall, the proposed project has two specific aims: 1) to confirm that DOMS results in increased demand for alcohol and marijuana; and to investigate race and sex as moderating factors of this association, and 2) to identify psychosocial risk factors associated with change in demand for alcohol and marijuana after DOMS induction. Results may be used to assist in identification of pain patients at risk for hazardous alcohol and marijuana use. They may also inform development of novel interventions for reducing risk of substance use disorders, particularly among those with pain. The proposed training plan will provide the applicant with additional training beyond that included in her PhD program. Specifically, training goals include 1) hands-on training for experimental research approaches, including musculoskeletal pain induction, 2) coursework in the application of behavioral economic principles to health behaviors in addition to didactic training in administration and analysis of behavioral economic measures, 3) training in advanced statistical approaches, 4) development of professional development skills, and [5) [formal training in neuropharmacology of alcohol and marijuana use, as well as biopsychosocial mechanisms of pain]. The applicant is supported by a strong research environment with the necessary resources for completion of the project and professional development, as well as a productive mentoring team with specific expertise in the proposed areas of study.

项目摘要/摘要 该提案的总体目标是提高有关疼痛的知识，作为使用物质使用的决定因素， 特别是酒精和大麻。大量研究表明疼痛的自我治疗 在疼痛患者中，有酒精和大麻（即用于应对和/或管理疼痛）很常见，并且 流行病学和观察性研究表明，疼痛可以作为使用物质的有效动机。 最初的实验证据表明，疼痛会增加饮酒的冲动和意图，但这 使用临床上的疼痛诱导方法具有更大的生态学，尚未复制关系 有效性比典型的实验疼痛方法。此外，尽管相似抑制疼痛的作用和共同 发生的使用酒精和大麻的模式，目前的研究尚未同时研究 疼痛对酒精和大麻使用的近端作用。因此，拟议的工作将尝试确定 实验引起的肌肉骨骼疼痛（即延迟发作肌肉酸痛； DOMS）是否可以 增加同事的酒精和大麻需求。将在一项实验研究中进行 哪些常规大麻和酒精的同事将被分配给DOMS（高强度偏心 锻炼）或假DOMS控制条件（低强度同心运动）。总体而言，提议的项目 有两个具体的目标：1）确认DOMS导致对酒精和大麻的需求增加；和 调查种族和性别作为该关联的调节因素，2）确定心理社会风险因素 与DOMS诱导后对酒精和大麻的需求变化有关。结果可以用来 协助确定有危险酒精和大麻风险的疼痛患者。他们也可能告知 开发新的干预措施，以降低药物使用障碍的风险，特别是 疼痛。拟议的培训计划将为申请人提供额外的培训 博士计划。具体而言，培训目标包括1）实验研究方法的动手培训， 包括肌肉骨骼疼痛诱导，2）应用行为经济原则的课程工作 健康行为除了在行为经济的管理和分析方面的教学培训外 措施，3）培训高级统计方法，4）专业发展技能的发展， 和[5）[酒精和大麻使用神经药理的正式培训，以及 疼痛的生物心理社会机制]。申请人得到了强大的研究环境的支持 完成项目和专业发展的必要资源以及富有成效的 指导团队在拟议的研究领域具有特定的专业知识。