Conduct of studies to evaluate the toxic potential of thallium (I) sulfate in laboratory animals

进行研究以评估硫酸铊 (I) 对实验动物的潜在毒性

• 批准号: 10388058
• 负责人: BARNEY SPARROW
• 金额: $ 81.95万
• 依托单位: BATTELLE MEMORIAL INSTITU
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2022-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10388058
• 关键词: Adverse effects; Chemicals; Data; Development; Dose; Ensure; Environmental Exposure; Evaluation Studies; Exposure to; Goals; Hazard Identification; Hazardous Chemicals; Health; Human; Laboratory Animals; Manuscripts; Mission; Mus; National Toxicology Program; Phase; Preparation; Program Reviews; Rattus; Risk Assessment; Route; Sulfate; Thallium; Toxic effect; Toxicity Tests; Toxicology; design; disorder prevention; drinking water; exposed human population; neurobehavioral; public health research; reproductive; sound

The goal of this project is to provide support of the Division of the National Toxicology Program (DNTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the conduct of toxicity studies of thallium (I) sulfate in rats and mice, following exposure in drinking water. This compound is found in drinking water and thus human exposure is anticipated via this route. In addition, thallium (I) sulfate is likely to be representative of other thallium compounds in drinking water. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity of thallium in rats and mice and ultimately supports the mission and goals of DNTP and risk assessment activities of other federal agencies. Keywords: toxicity, drinking water, thallium

该项目的目的是提供支持国家毒理学计划（DNTP）危害识别活动，该危害识别活动针对预防疾病或由环境暴露于化学或物理药物引起的不良影响。毒性测试是公共卫生研究的重要方面，它有助于识别对人类健康有害的化学物质。需要正确进行毒理学研究，以确保所得数据可靠。该项目涉及在饮用水中暴露后，在大鼠和小鼠中对硫酸盐（I）的毒性研究进行。这种化合物在饮用水中发现，因此通过这种途径预计人类的暴露。此外，硫酸硫酸硫酸硫酸盐可能代表饮用水中其他硫酸盐化合物。该项目的数据将用于开发声音，科学结论，内容涉及大鼠和小鼠的潜在毒性，并最终支持DNTP的使命和目标以及其他联邦机构的风险评估活动。 关键字：毒性，饮用水，thallium