Exploring the brain basis of rhythm in individuals with aphasia

探索失语症患者节律的大脑基础

• 批准号: 10386555
• 负责人: Anna Victoria Kasdan
• 金额: $ 3.08万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10386555
• 关键词: Acquired Communication Disorders; Address; Affect; Age; Alpha Rhythm; Aphasia; Area; Auditory; Basal Ganglia; Basic Science; Behavioral; Brain; Brain Injuries; Brain region; Brain scan; Chronic; Clinic; Clinical; Clinical Research; Clinical Sciences; Cognitive; Communication impairment; Conflict (Psychology); Control Groups; Data Analyses; Discrimination; Disease; Elements; Empirical Research; Exhibits; Future; Goals; Heterogeneity; Impairment; Individual; Individual Differences; Inferior frontal gyrus; Knowledge; Language; Lead; Left; Lesion; Linguistics; Link; Literature; Location; Measures; Mentored Research Scientist Development Award; Methodology; Motor; Music; Neurobiology; Output; Participant; Pathologist; Patients; Pattern; Perception; Performance; Periodicity; Population; Production; Recovery; Rehabilitation therapy; Role; Speech; Stimulus; Stroke; Structure; Symptoms; Techniques; Therapeutic; Time; Tissues; Training; United States; Work; base; behavioral study; brain behavior; clinically relevant; cohort; experimental study; improved; individual variation; infancy; knowledge base; machine learning method; melodic intonation therapy; neuromechanism; post stroke; precision medicine; preservation; relating to nervous system; skills; stem; stroke-induced aphasia; therapy development; therapy outcome; trait

PROJECT SUMMARY The goal of this proposal is to characterize the neural substrates underlying rhythm abilities and the relationship with language profiles in individuals with aphasia. Aphasia is an acquired communication disorder resulting from damage to language regions of the brain, with stroke as the leading cause. Currently, over 2 million individuals in the United States are living with aphasia. Aphasia is notoriously difficult to treat and patients exhibit significant individual variability in recovery trajectories and in what therapeutic elements work best in aiding such recovery. Speech-language pathologists frequently use rhythmic elements (e.g., tapping to a beat) in the clinic in order to facilitate speech output. However, there is a lack of a deep and systematic empirical assessment of rhythm in aphasia at both a behavioral and neural level. Our first aim is to characterize the neural basis of individual differences in rhythm abilities in individuals with chronic, post-stroke aphasia. To do this, we will administer a comprehensive battery of rhythm perception and production tasks to a large cohort of individuals with aphasia and age-matched controls. We will then employ multivariate lesion-symptom mapping, a machine-learning methodology for identifying brain-behavior relationships, to determine which brain regions are associated with rhythm processing in aphasia. We hypothesize that individuals who have damage to brain regions important for rhythm, including the basal ganglia or the left inferior frontal gyrus (LIFG), will exhibit the greatest impairments in rhythm. Critically, the LIFG is a core language region typically damaged in post-stroke, non-fluent aphasia. Motivated by robust evidence for associations between rhythm and language across cognitive, neural, and behavioral domains, we will assess the relationship between rhythm and language measures in aphasia in our second aim. We predict that individuals with higher rhythm abilities will have higher language scores, particularly on measures of connected speech. This mentored training award will provide the applicant with training in advanced neural and behavioral data analysis techniques and expertise in large-scale project management with a patient cohort. With significant and timely clinical relevance, our proposal will address vital gaps in the literature by taking an individual differences approach to understanding the relationship between rhythm, the brain, and language in aphasia.

项目概要 该提案的目标是描述节律能力背后的神经基质和 与失语症患者语言特征的关系。失语症是一种后天性沟通障碍 由大脑语言区域受损引起，其中中风是主要原因。目前，超过2 美国有 100 万人患有失语症。众所周知，失语症很难治疗， 患者在恢复轨迹和治疗要素发挥作用方面表现出显着的个体差异 最好地帮助这种恢复。言语病理学家经常使用节奏元素（例如，轻敲以 一个节拍）在诊所中以利于语音输出。但缺乏深入、系统的 在行为和神经水平上对失语症节律进行实证评估。 我们的首要目标是描述患有以下疾病的个体节律能力个体差异的神经基础： 慢性、中风后失语。为此，我们将管理一套全面的节律感知和 将生产任务分配给一大群失语症患者和年龄匹配的对照组。然后我们将雇用 多变量病变症状映射，一种识别大脑行为的机器学习方法 关系，以确定哪些大脑区域与失语症的节律处理相关。我们 假设对节律重要的大脑区域（包括基底神经节）受损的个体 神经节或左额下回 (LIFG) 将表现出最大的节律损伤。关键的是， LIFG 是一个核心语言区域，通常会因中风后不流利的失语症而受损。 受到节奏和语言在认知、神经和语言方面的关联的有力证据的推动 行为领域，我们将评估失语症的节奏和语言测量之间的关系 第二个目标。我们预测节奏能力较高的人将获得较高的语言分数， 特别是在连接语音的测量上。 该指导培训奖将为申请人提供高级神经和行为数据方面的培训 大型患者群体项目管理的分析技术和专业知识。具有显着和 及时的临床相关性，我们的建议将通过个体差异来解决文献中的重要空白 理解失语症的节律、大脑和语言之间关系的方法。