Administrative Core

行政核心

• 批准号: 10385162
• 负责人: Laura Jane Niedernhofer
• 金额: $ 33.02万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10385162
• 关键词: Administrative; Core; Administrative; Core

Project Summary The Minnesota Tissue Mapping Center (MN TMC) for Senescent Cells (SnC) Administrative Core (AC) will be led by two PIs with synergistic expertise: Dr. Laura Niedernhofer, an expert in cellular senescence who participated in the numerous NIH Think Tanks that led to this Common Fund U54 RFA, and Dr. Constantin Aliferis, Director of the UMN Institute for Health Informatics (IHI) and Chief Research Informatics Officer. The main goals of the AC are to facilitate the interaction of all of the MN TMC cores to maximize the TMCs productivity and to create a seamless interface between the MN TMC and other TMCs, the Consortium Organization and Data Coordinating Center (CODCC), and the technology grant (UG3/UH3) awardees to maximize the synergy and productivity of the SenNet Consortium. The specific responsibilities of the AC are to: i) coordinate and provide oversight for the activities of the MN TMC Cores to facilitate access to human tissues, subject clinical data, tissue analysis, data analysis, and data integration; ii) administer a pilot project program focused on developing innovative approaches to identify and characterize SnCs; iii) coordinate MN TMC activities with those of the other TMCs, including working with our Data Analysis Core (DAC) and the CODCC to create standard operating procedures (SOPs) for data management and dissemination; and iv) work with the DAC to ensure delivery of the data generated by our TMC to the CODCC in a timely fashion and in compliance with the SenNet standard operating procedures and Common Data Elements set by the SenNet Steering Committee. The goals of the AC will be achieved through the following aims: 1) Oversee and coordinate efforts of the MN TMC to ensure that research goals and milestones are met with highest quality standards; 2) Integrate input from the MN TMC DAC and the SenNet CODCC to develop and ensure compliance with SOPs for generating data sets that enable the development of a multi-dimensional atlas of SnCs with healthy human aging. 3) Oversee and coordinate the exploration and evaluation of novel approaches for detecting, deeply phenotyping, tracing, and selectively eliminating senescent cells as technologies emerge from pilot projects, Technology Development Projects (UG3/UH3), other TMCs, and other relevant groups studying senescence or building cell atlases; and 4 ) Coordinate the activities of MN TMC with other TMCs to optimize research efficiency and economies of scale and scope, including contributing to the adoption and/or further development of data standards, analytic tools, data sharing/visualization/discovery tools, and multi-site studies and training activities. Successful execution of these aims will optimize the operations of MN TMC, maximize our contribution to SenNet, ensure SOPs that enhance the rigor and reproducibility of the data collected on SnCs, and ensure compliance of our TMC with the Standard Practices established by SenNet.

项目摘要 明尼苏达州组织映射中心（MN TMC）用于衰老细胞（SNC）行政核心（AC） 由两个具有协同专业知识的PI的领导：Laura Niedernhofer博士，蜂窝衰老专家 参与了导致这个普通基金U54 RFA的众多NIH智囊团和康斯坦丁博士 UMN健康信息学研究所（IHI）和首席研究信息学官员Aliferis。这 AC的主要目标是促进所有MN TMC核的相互作用，以最大化TMCS 生产力并在MN TMC和其他TMC之间创建无缝接口界面 组织和数据协调中心（CODCC）以及技术赠款（UG3/UH3）获奖者 最大化Sennet财团的协同和生产力。 AC的具体职责是 至：i）协调并为MN TMC核心的活动提供监督以促进与人类的接触 组织，主题数据，组织分析，数据分析和数据整合； ii）管理一个试点项目 计划着重于开发创新方法来识别和表征SNC； iii）坐标Mn 与其他TMC的TMC活动，包括使用我们的数据分析核心（DAC）和 CODCC创建用于数据管理和传播的标准操作程序（SOP）；和iv）工作 使用DAC确保我们的TMC生成的数据及时到达CODCC 符合Sennet Sennet设置的Sennet标准操作程序和常见数据元素 指导委员会。 AC的目标将通过以下目的实现：1）监督和协调MN的努力 TMC确保研究目标和里程碑符合最高质量标准； 2）从 MN TMC DAC和Sennet CodCC开发并确保符合生成数据的SOP 设置可以开发健康衰老的SNC的多维地图集。 3）监督 并协调对检测，深层表型，追踪，探索和评估的探索和评估 并有选择地消除衰老细胞，因为从试点项目中出现技术，技术开发 项目（UG3/UH3），其他TMC和其他研究衰老或建筑细胞地图集的相关群体；和 4 ）协调MN TMC与其他TMC的活动，以优化研究效率和规模经济 和范围，包括为数据标准，分析工具，分析工具的采用和/或进一步发展 数据共享/可视化/发现工具以及多站点研究和培训活动。成功执行 这些目标将优化MN TMC的运营，最大化我们对Sennet的贡献，确保SOPS 增强在SNC上收集的数据的严格性和可重复性，并确保我们的TMC遵守 Sennet建立的标准实践。