Investigation of Neighborhood Greenspace as Protection Against Development of Childhood Asthma

邻里绿地预防儿童哮喘发展的调查

• 批准号: 10373233
• 负责人: ANNECLAIRE J DE ROOS
• 金额: $ 24.44万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10373233
• 关键词: Address; Affect; Age; Air Pollutants; Air Pollution; Area; Asthma; Biodiversity; Birth; Birth Records; Black race; Caucasians; Characteristics; Child; Childhood; Childhood Asthma; Classification; Clinical; Data; Databases; Development; Diagnosis; Disease; Electronic Health Record; Environment; Environmental Exposure; Ethnic Origin; Etiology; Excision; Exposure to; Extrinsic asthma; Green space; Health; Health system; Heterogeneity; Home; House Dust; Immune; Incidence; Individual; Infant; Institution; Intervention; Investigation; Joints; Knowledge; Life; Link; Longitudinal Studies; Longitudinal cohort; Measures; Minority; Modeling; Modification; Morbidity - disease rate; Neighborhoods; Ozone; Pathway interactions; Phenotype; Philadelphia; Poaceae; Population; Population Density; Poverty; Race; Research; Resolution; Resources; Risk; Risk Factors; Role; Subgroup; Testing; Time; Trees; Variant; Wheezing; atopy; base; boys; clinical effect; clinical phenotype; cohort; density; design; early childhood; early life exposure; fine particles; follow-up; girls; health disparity; high risk; infancy; land cover; low socioeconomic status; metropolitan; microbial; microbiome; microbiome composition; prevent; protective effect; rural setting; sociodemographics; spatiotemporal; suburb; urban area; urban setting

PROJECT SUMMARY/ABSTRACT Emerging evidence suggests that exposure to vegetated land cover, or ‘greenspace’, particularly in early life, may prevent development of asthma. One proposed mechanism behind this relationship describes microbial diversity of natural landscapes contributing to diverse microbiome profiles in children who live nearby, thus supporting robust immune development. Another proposed mechanism involves removal of asthma-causing air pollutants by tree canopy. We propose a study of neighborhood greenspace in relation to the asthma incidence, in a longitudinal cohort of over 170,000 children living in the Philadelphia metropolitan region, followed from infancy. In the proposed study, we will link electronic health records (EHR) from the defined cohort to high-spatial resolution greenspace metrics, by children’s individual geocoded addresses. Our rich database will also include an array of additional environmental and sociodemographic measures of the neighborhoods where children live, needed to disentangle the individual effects of greenspace from other neighborhood factors, and also enabling a meaningful analysis of the joint effects of greenspace with other conditions that may enhance or diminish the potential greenspace benefits. In our study, we specifically aim to: 1) Investigate the association between neighborhood greenspace and asthma incidence from infancy through childhood (specifically, ages 2, 7 and 12) in a cohort of urban and suburban children; 2) Evaluate modification of the relationship between greenspace and asthma incidence by other neighborhood characteristics that may alter risk or vulnerability, including air pollution (PM2.5, O3), traffic, urban status, and sociodemographics; and, 3) Describe heterogeneity of the association with neighborhood greenspace among asthma phenotypes. We will evaluate several greenspace measures in relation to asthma incidence, including overall greenness, tree canopy coverage, grass/shrubs, natural landcover diversity, and spatial attributes of green spaces (e.g., patch size, aggregation), and we will investigate these measures as time-window specific (e.g., infancy) and cumulative greenspace exposures during follow-up. Our study will provide a robust analysis of the potential for urban greenspace exposure in early life to protect against development of asthma. In addition, information from subgroup and phenotype analyses may provide clues regarding the mechanisms by which greenspace may affect risk of asthma, as well as the scope of potential impact.

项目概要/摘要 新出现的证据表明，暴露于植被覆盖或“绿色空间”，特别是在生命早期， 这种关系背后提出的一种机制描述了微生物。 自然景观的多样性有助于居住在附近的儿童的不同微生物组特征，因此 支持强大的免疫发育的另一个机制涉及去除引起哮喘的空气。 我们提出了一项与哮喘相关的邻近绿地的研究。 居住在费城大都市区的超过 170,000 名儿童的纵向队列中的发病率， 从婴儿期开始，我们将把电子健康记录（EHR）与定义的联系起来。 通过儿童的个人地理编码地址，我们可以将其归为高空间分辨率的绿地指标。 数据库还将包括一系列额外的环境和社会人口统计指标 儿童居住的社区需要将绿地与其他绿地的个体影响分开 邻里因素，还可以对绿地与其他空间的联合影响进行有意义的分析 可能增强或减弱潜在绿地效益的条件 在我们的研究中，我们的具体目标是： 1) 调查社区绿地与从婴儿期到哮喘发病率之间的关联 城市和郊区儿童群体的童年（特别是 2、7 和 12 岁）2) 评估修改； 绿地与哮喘发病率之间关系的其他邻里特征可能 改变风险或脆弱性，包括空气污染（PM2.5、O3）、交通、城市状况和社会人口统计； 3）描述哮喘表型与邻里绿地关联的异质性。 将评估与哮喘发病率相关的多项绿地措施，包括整体绿化度、树木 树冠覆盖度、草/灌木、自然土地覆盖多样性以及绿色空间的空间属性（例如斑块） 大小、聚合），我们将根据特定时间窗口（例如婴儿期）和 我们的研究将对后续过程中的累积绿地暴露量提供强有力的分析。 生命早期接触城市绿地可预防哮喘的发生。 亚组和表型分析可能提供有关绿地可能的机制的线索 影响哮喘风险以及潜在影响的范围。