Auditory Rehabilitation Needs in COVID-19 Survivors

COVID-19 幸存者的听觉康复需求

• 批准号: 10370229
• 负责人: Kelly M. Reavis
• 金额: --
• 依托单位: PORTLAND VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10370229
• 关键词: 2019-nCoV; ACE2; Acute; Adverse effects; Affect; Auditory; Auditory system; Award; Bacterial Pneumonia; Biological; Brain; COVID-19; COVID-19 impact; COVID-19 patient; COVID-19 risk; COVID-19 survivors; COVID-19 treatment; Cadaver; Caring; Case Series; Case Study; Cells; Chronic; Clinical; Coagulation Process; Cochlea; Communicable Diseases; Complex; Computerized Medical Record; Consequentialism; Cytomegalovirus; Data; Disease; Ear; Earache; Endothelium; Epithelial Cells; Functional disorder; Future; Goals; Health; Healthcare Systems; Hearing; Hearing Tests; Hearing problem; Hospitalization; Hyperacusis; Immune system; Infection; Inflammation; Inflammatory; Interview; Ischemia; Life; Life Experience; Literature; Mastoid process; Measles; Measures; Meningitis; Methods; Morbidity - disease rate; Multiple Organ Failure; Mumps; Nervous system structure; Otitis Media; Pathway interactions; Patients; Phase; Pilot Projects; Prevalence; Quality of life; Receptor Cell; Recording of previous events; Rehabilitation therapy; Reporting; Research Proposals; Respiratory Signs and Symptoms; Respiratory System; Respiratory distress; Risk; Rubella; SARS-CoV-2 exposure; SARS-CoV-2 infection; SARS-CoV-2 positive; Structure; Sudden Hearing Loss; Survey Methodology; Surveys; Survivors; Systemic infection; Temporal Lobe; Testing; Therapeutic; Time; Tinnitus; Vascular Smooth Muscle; Veterans; Viral; Virus; Work; adverse outcome; auditory pathway; auditory rehabilitation; base; comorbidity; cytokine; cytokine release syndrome; design; experience; hearing impairment; improved; interest; long term consequences of COVID-19; male; middle ear; military veteran; mortality; novel coronavirus; ototoxicity; pandemic disease; patient population; rehabilitation research; rehabilitation service; rehabilitative care; research and development; sepsis induced ARDS

Project Background/Rationale: The purpose of this proposal is to quantitatively examine and qualitatively understand the impact of COVID-19 on Veterans' auditory function. Since the pandemic began, over 230,000 Veterans in the VA health care system have tested or been presumed positive for COVID-19. It has been hypothesized that COVID-19 may have adverse effects on the auditory system, although the extent is unknown. Viral induced hearing loss is not a new phenomenon and several case studies and case series have reported new onset and progression of hearing loss and tinnitus, sudden hearing loss (sudden occurrence of acute hearing loss), ear pain, noise sensitivity and otitis media with respect to COVID-19. Moreover, we are lacking an understanding of the auditory rehabilitation needs of COVID-19 survivors. This evidence is required to successfully restore and return Veterans' auditory function to improve their quality of life. Project Aims: There is a need to understand the short- and long-term consequences of COVID-19 on the auditory system, especially among Veterans who are already at risk for underlying auditory complications, and to conceptualize these within a rehabilitation framework. The specific aims of this research proposal are to (1) Quantify the burden and impact of COVID- 19 on Veterans' auditory function; and (2) Describe Veterans' experiences with auditory complications following COVID-19 with respect to timing, onset, clinical course, rehabilitation needs, and quality of life. Project Methods: This 2-year pilot project will be accomplished through a mixed-methods approach with a sequential quantitative-qualitative design. Quantitative data regarding COVID- 19 auditory sequelae will be gathered via patient surveys and review of the electronic medical record (n=1,566). Qualitative data will be gathered via semi-structured interviews with COVID- 19 patients (n=40). By focusing on the personal and lived experiences among Veterans with COVID-19, the qualitative aim will explore emerging issues and contextual nuances otherwise unmeasurable using survey methods. Data will be stratified by hospitalization history so that unique needs of Veterans with more severe disease can be examined. Anticipated Impact: Completion of the proposed study will provide evidence for the impacts of COVID-19 on the auditory system. It is our goal to immediately provide clinicians with a better understanding of this complex patient population, functional limitations, and perceived rehabilitation needs. Observed hearing loss and tinnitus may very well become chronic, so the audiological impact of the pandemic may substantially outlast the current phase. Results of this study will lead to a VA Rehabilitation Research & Development, Merit Award application exploring the longitudinal effects of COVID-19 on the ear, hearing, and tinnitus using more robust and audiometric test measures not feasible in this pilot study.

项目背景/理由：本提案的目的是定量检查和 定性了解 COVID-19 对退伍军人听觉功能的影响。自从 大流行开始后，退伍军人管理局医疗保健系统中超过 230,000 名退伍军人已经接受检测或接受治疗 推测对 COVID-19 呈阳性。据推测，COVID-19 可能会对 对听觉系统的影响，但程度尚不清楚。病毒引起的听力损失不是 一种新现象和一些案例研究和案例系列报告了新的发病和 听力损失和耳鸣的进展、突发性听力损失（突然发生急性听力损失） 与 COVID-19 相关的听力损失）、耳痛、噪音敏感性和中耳炎。而且， 我们对 COVID-19 幸存者的听力康复需求缺乏了解。 需要此证据才能成功恢复退伍军人的听觉功能 提高他们的生活质量。 项目目标：需要了解短期和长期后果 COVID-19 对听觉系统的影响，尤其是已经面临听力系统风险的退伍军人 潜在的听觉并发症，并在康复框架内将其概念化。 本研究提案的具体目标是 (1) 量化新冠肺炎的负担和影响 19 关于退伍军人的听觉功能； (2) 描述退伍军人的听觉体验 COVID-19 后并发症的时间、发病时间、临床过程、康复 需求和生活质量。 项目方法：这个为期两年的试点项目将通过混合方法完成 采用顺序定量-定性设计的方法。有关新冠肺炎的定量数据 通过患者调查和电子医疗审查，将收集 19 种听觉后遗症 记录（n=1,566）。定性数据将通过对新冠病毒的半结构化访谈来收集 19 名患者 (n=40)。通过关注退伍军人的个人和生活经历 COVID-19，定性目标将探讨新出现的问题和上下文的细微差别 使用调查方法无法测量。数据将按住院史分层，以便 可以检查患有更严重疾病的退伍军人的独特需求。 预期影响：完成拟议的研究将为以下影响提供证据 COVID-19 对听觉系统的影响。我们的目标是立即为临床医生提供更好的 了解这一复杂的患者群体、功能限制和感知 康复需求。观察到的听力损失和耳鸣很可能会变成慢性，因此 流感大流行对听力的影响可能会大大超过当前阶段。结果 研究将导致退伍军人管理局康复研究与开发优异奖申请 使用更多信息探索 COVID-19 对耳朵、听力和耳鸣的纵向影响 稳健的听力测试措施在本试点研究中不可行。