The Neural Effects of Balance Versus Aerobic Training in Individuals with Degenerative Cerebellar Diseases

平衡与有氧训练对退行性小脑疾病患者的神经影响

基本信息

批准号：
10371300
负责人：
Scott Barbuto
金额：
$ 19.35万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10371300
关键词：
Aerobic Aerobic Exercise Affect Animals Area Ataxia Back Balance training Brain Brain scan Cerebellar Diseases Cerebellar degeneration Cerebellum Cessation of life Clinical Clinical Research Data Dendrites Diagnosis Diffusion Magnetic Resonance Imaging Disease Disease Progression Doctor of Philosophy Equilibrium Exercise Financial compensation Future Goals Home Immunology Individual Inherited K-Series Research Career Programs Learning Locomotion MRI Scans Master&apos s Degree Measures Mentors Methods Motor Skills Movement Disorders Neurologic Neurologic Signs Neuronal Plasticity Participant Pharmaceutical Preparations Physical Medicine Physical Rehabilitation Population Public Health Randomized Regimen Research Research Design Research Personnel Research Project Grants Research Support Rest Spinocerebellar Ataxias Spinocerebellar Degenerations Statistical Data Interpretation Statistical Methods Structure Synapses Techniques Testing Training Training Programs United States National Institutes of Health Wheelchairs Work career career development clinically significant disability effective therapy exercise training functional MRI scan gray matter improved interest multidisciplinary neuroimaging programs relating to nervous system responsible research conduct sedentary skills symptomatic improvement

Aerobic Aerobic Exercise Affect Animals Area Ataxia Back Balance training Brain Brain scan Cerebellar Diseases Cerebellar degeneration Cerebellum Cessation of life Clinical Clinical Research Data Dendrites Diagnosis Diffusion Magnetic Resonance Imaging Disease Disease Progression Doctor of Philosophy Equilibrium Exercise Financial compensation Future Goals Home Immunology Individual Inherited K-Series Research Career Programs Learning Locomotion MRI Scans Master&apos s Degree Measures Mentors Methods Motor Skills Movement Disorders Neurologic Neurologic Signs Neuronal Plasticity Participant Pharmaceutical Preparations Physical Medicine Physical Rehabilitation Population Public Health Randomized Regimen Research Research Design Research Personnel Research Project Grants Research Support Rest Spinocerebellar Ataxias Spinocerebellar Degenerations Statistical Data Interpretation Statistical Methods Structure Synapses Techniques Testing Training Training Programs United States National Institutes of Health Wheelchairs Work career career development clinically significant disability effective therapy exercise training functional MRI scan gray matter improved interest multidisciplinary neuroimaging programs relating to nervous system responsible research conduct sedentary skills symptomatic improvement

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项目摘要

PROJECT SUMMARY/ABSTRACT Degenerative cerebellar diseases are a group of disorders that cause severe disability and can be fatal. There are currently no known disease-modifying treatments available for use, and there is a critical need to find treatments that slow disease progression and allow affected individuals to live more functional lives. Balance and aerobic training show promise as treatments for degenerative cerebellar diseases, but the neural effects of both training methods have not been thoroughly investigated. It is crucial to understand how the training impacts the brain, and particularly the cerebellum, in order to determine if one training method is better at slowing disease progression than the other. The goal of this proposal is to compare the neural effects of balance versus aerobic training in individuals with degenerative cerebellar diseases. We hypothesize that aerobic training causes neuroplastic changes within the cerebellum whereas balance training causes improvements for people with cerebellar degeneration by impacting brain structures outside the cerebellum. If our hypothesis is true, aerobic training may have more influence on disease progression than balance training as it directly impacts the cerebellum. To investigate our hypothesis, various neuroimaging techniques will be used, which will allow the candidate to gain invaluable expertise in processing and analyzing brain scans. In AIM 1, we will compare cerebellar volume before and after the participants perform either 6-months of balance or aerobic training. In AIM 2, we will investigate whether neural changes have clinical significance by correlating cerebellar volume changes with clinical measures of ataxia. Finally, for AIM 3, we will use diffusion tensor imaging and resting state fMRI scans to examine how both training methods impact cerebellar microstructure and functional cerebellar connections. We hope that a detailed understanding of how each training method impacts the cerebellum will lead to more targeted training regimens with the goal of slowing disease progression of these devastating diseases. The candidate has a clinical background in Physical Medicine and Rehabilitation with an emphasis on movement disorders. He has a PhD in immunology and will be completing a master’s degree in clinical research design and statistical analysis. He is committed to a career in ataxia research focusing on the effects of exercise training on disease progression and plans to use the additional training he receives through this NIH Career Development Award to support his future work in this field. The candidate has assembled a multidisciplinary mentoring team to accomplish three training goals: 1) to learn and master neuroimaging techniques; 2) to become proficient in longitudinal statistical methods; 3) to improve grantsmanship skills to facilitate ongoing research support. In addition, the candidate will receive further training in career development and the responsible conduct of research.

项目摘要/摘要小脑疾病是一群造成严重残疾并且可能致命的疾病。那里目前尚无可供使用的已知疾病修改治疗方法，并且有至关重要的需要缓慢疾病进展并允许受影响个体的治疗方法。平衡有氧训练表明有望作为对小脑疾病的治疗方法，但神经影响两种训练方法尚未经过彻底研究。了解如何培训是至关重要的影响大脑，尤其是小脑，以确定一种训练方法是否更好疾病进展放缓的进展比其他人的进展减慢。该提议的目的是比较患有平衡与有氧训练的神经影响退化性小脑疾病。我们假设有氧训练会导致神经塑性变化小脑，而平衡培训则通过影响小脑外的大脑结构。如果我们的假设是正确的，有氧训练可能会有更多对疾病进展的影响而不是平衡训练，因为它直接影响小脑。为了研究我们的假设，将使用各种神经影像学技术，这将使候选人能够在处理和分析脑部扫描方面获得宝贵的专业知识。在AIM 1中，我们将比较小脑参与者进行6个月的平衡或有氧训练之前和之后的体积。在AIM 2中，我们将调查中性变化是否通过相关的小脑体积变化是否具有临床意义与共济失调的临床测量。最后，对于AIM 3，我们将使用扩散张量成像和静止状态fMRI 扫描以检查两种训练方法如何影响小脑微观结构和功能性小脑连接。我们希望对每种训练方法如何影响小脑有详细的了解导致更具针对性的训练方案，目的是减慢这些破坏性的疾病进展疾病。候选人具有物理医学和康复的临床背景，重点是运动障碍。他拥有免疫学博士学位，并将完成临床硕士学位研究设计和统计分析。他致力于共济失调研究的职业，重点关注效果关于疾病进展的运动培训，并计划使用他接受的其他培训 NIH职业发展奖旨在支持他在这一领域的未来工作。候选人组装了多学科指导团队实现三个培训目标：1）学习和掌握神经影像学技术； 2）精通纵向统计方法； 3）提高授予技巧促进正在进行的研究支持。此外，候选人将接受进一步的职业发展培训以及负责任的研究。