Extending a Caribbean Based Cohort to Promote US-Caribbean Comparisons to Facilitate Research Addressing Black Health Disparities

扩大加勒比地区的队列以促进美国与加勒比地区的比较，以促进解决黑人健康差异的研究

• 批准号: 10367985
• 负责人: Kimlin Tam Ashing
• 金额: $ 67.06万
• 依托单位: RESEARCH INST OF FOX CHASE CAN CTR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10367985
• 关键词: Address; African; African American; African Caribbean; Area; Award; Behavioral; Behavioral Risk Factor Surveillance System; Biological; Black American; Black Populations; Black race; Cardiometabolic Disease; Cardiovascular Diseases; Caribbean region; Centers of Research Excellence; Chronic Disease; Cohort Studies; Collection; Community Health Nursing; Comparative Study; Country; Data; Data Analytics; Data Collection; Data Set; Delaware; Enrollment; Environmental Health; Epidemiology; Feedback; Field Workers; Fox Chase Cancer Center; Future; Genomics; Goals; Health; Health Status; Healthcare; Healthcare Systems; Heterogeneity; Immigrant; Immigration; Incidence; Infrastructure; Interviewer; Jamaica; Jamaican; Life Style; Link; Longitudinal cohort; Malignant Neoplasms; Measures; Medical History; Methods; Minority; Morbidity - disease rate; Mouthwash; National Health and Nutrition Examination Survey; New Jersey; New York; Not Hispanic or Latino; Outcome; Participant; Persons; Philadelphia; Population; Premature Mortality; Prevalence; Questionnaires; Race; Research; Research Support; Resources; Risk Factors; Sampling; Secure; Specimen; Subgroup; Surveys; United States; United States National Institutes of Health; Universities; Urine; Variant; West Indies; base; behavioral health; burden of illness; cancer prevention; cancer risk; cardiovascular disorder prevention; cardiovascular disorder risk; cohort; comparative; cultural health; data harmonization; data integration; data mining; data sharing; effectiveness evaluation; epidemiologic data; ethnic diversity; health disparity; instrument; metropolitan; mortality; population based; population health; programs; racial and ethnic; response; retention rate; sharing platform; surveillance study

PROJECT SUMMARY/ABSTRACT Fifty percent of Non-Hispanic Black immigrants in the United States (US) originate from the Caribbean. Thus the health of US and Caribbean populations are closely intertwined due to both regional proximity and the high volume of Caribbean immigration to the US3. US and Caribbean Blacks also share disease burden; cancer and cardiovascular disease (CVD) account for their greatest health disparities-- killing more Black individuals in the US and the Caribbean than any other ethnic/racial group. Yet, there is a paucity of cancer and CVD comparative research between the US-born Black American and African-Caribbean sub-groups. While the NIH has invested in studying US minority/immigrant populations, comparisons with Caribbean cohorts are needed to untangle the effect of biological, environmental, behavioral, and cultural health care system determinants of CVD and cancer risk and outcomes. In partnership with the University of the West Indies (UWI), the African Caribbean Cancer Consortium (AC3) is already making headway into expanding an existing population-based cohort for cancer and CVD research in Jamaica. The Jamaica Health and Lifestyle Survey (JHLS-III), conducted in 2016-17, is a national representative sample of over 3000 persons. The JHLS-III collected bio-specimens and epidemiological data on CVD, cancer, other chronic diseases and their risk factors, and medical history. To the best of our knowledge, there are no other nationally representative population-based cohorts in the Caribbean specifically targeting cancer combined with other chronic diseases. With an NCI-P20 award, the AC3, an NCI-Epidemiology and Genomics Research Program supported consortium at Fox Chase Cancer Center and UWI have established a Caribbean Regional Center of Research Excellence in Cardiometabolic Disease and Cancer. This proposal will be a natural extension of this project by expanding the JHLS-III and building the data mining, storage and analytics infrastructure needed to harness and share data from epidemiological measures and biospecimens to promote comparative research in cancer and cardiometabolic disease. This proposed infrastructure building project will harness and prepare multi-level data for future US-Caribbean comparative studies. We propose to optimize enrollment and retention of Caribbean nationals in cohort studies by (a) obtaining multi-stakeholder input and feedback from community health nurses/field workers and JHLS-III 2016/17 cohort participants to refine targeted enrollment and retention strategies; and (b) evaluating the effectiveness of this strategy relative to historical enrollment and retention rates. We will repurpose and expand the JHLS-III into a robust longitudinal cohort of 8,000 participants, collect and store biospecimens, socioecological and health status data in order to answer questions about NCD (i.e. cancer and CVD) risk and outcomes. We will establish a secure data integration and sharing platform that will enable linkages of the Jamaica cohort with the CAP3 study and other Caribbean and US-based cohorts, and conduct preliminary analytics for data verification and harmonization.

项目摘要/摘要 美国（美国）的非西班牙裔黑人移民中有50％来自加勒比海。因此 由于区域邻近和高度 加勒比移民的数量到US3。美国和加勒比黑人也有疾病负担；癌症和 心血管疾病（CVD）是其最大的健康差异 - 杀死更多黑人个体 美国和加勒比海地区比任何其他种族/种族群体。然而，癌症和CVD比较很少 美国出生的黑人美国和非洲加勒比海群之间的研究。 NIH投资 在研究美国少数民族/移民人群时，需要与加勒比队的比较来解开 CVD和癌症的生物，环境，行为和文化保健系统决定因素的影响 风险和结果。与非洲加勒比癌的西印度群岛大学（UWI）合作 财团（AC3）已经在扩大现有的基于人群的癌症队列的方向 和牙买加的CVD研究。牙买加健康与生活方式调查（JHLS-III）于2016 - 17年进行，是 全国代表性的3000多人样本。 JHLS-III收集了生物特异性和流行病学 有关CVD，癌症，其他慢性疾病及其危险因素以及病史的数据。尽我们所能 知识，在加勒比海中没有其他国家代表性的人群 靶向癌症与其他慢性疾病相结合。 NCI-P20奖，AC3，NCI-EPIDEMIology 基因组学研究计划支持Fox Chase Cancer Center和UWI的财团建立 加勒比地区的心脏代谢疾病和癌症卓越研究中心。这个建议 通过扩展JHLS-III并构建数据挖掘，存储和 分析基础设施需要利用和共享流行病学措施和生物测量的数据到 促进癌症和心脏代谢疾病的比较研究。这个拟议的基础设施建筑 项目将利用并准备多层数据，以进行未来的美国加勒比比较研究。我们建议 优化（a）获得多利益相关者的加勒比国民在队列研究中的入学和保留 社区卫生护士/现场工作人员和JHLS-III 2016/17队列参与者的投入和反馈 精炼有针对性的入学和保留策略； （b）评估该策略相关的有效性 历史入学率和保留率。我们将重新利用并将JHLS-III扩展为强大的纵向 由8,000名参与者组成的队列，收集和存储生物测量，社会生态和健康状况数据，以便 回答有关NCD（即癌症和CVD）风险和结果的问题。我们将建立安全的数据 集成和共享平台将使牙买加队列与CAP3研究和其他 加勒比和美国的同类队列，并进行初步分析以进行数据验证和协调。