ENDS use trajectories from adolescence through young adulthood: A longitudinal study of risk factors and profiles

ENDS 从青春期到成年早期的使用轨迹：风险因素和概况的纵向研究

• 批准号: 10348132
• 负责人: Melissa Blythe Harrell
• 金额: $ 64.18万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-15 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10348132
• 关键词: 15 year old; 17 year old; Acceleration; Adolescence; Adolescent; Adolescent and Young Adult; Age; Age-Years; Area; Behavior; Behavioral; Cigarette; Cohort Studies; Data; Data Collection; Demographic Factors; Development; Electronic Nicotine Delivery Systems; Environmental Risk Factor; Escalator; Esthesia; Ethnic Origin; Exhibits; Female; Friends; Growth; Health; Heterogeneity; High Prevalence; High School Student; Hispanic Populations; Life; Life Cycle Stages; Link; Longitudinal Studies; Marketing; Measures; Methodology; Methods; Modeling; Natural History; Nicotine Dependence; Not Hispanic or Latino; Online Systems; Outcome; Pattern; Perception; Persons; Play; Post Graduate Year; Race; Reporting; Research; Risk; Risk Factors; Role; Sales; Sampling; Students; Subgroup; Surveys; Testing; Texas; Time; Tobacco; Tobacco use; age group; austin; behavioral health; cigarette smoking; cohort; combustible tobacco; design; early adolescence; effective intervention; eighth grade; follow-up; high risk; high school; implementation intervention; innovation; junior high school; male; marijuana use; metropolitan; peer; population based; preventive intervention; sex; sixth grade; tenth grade; tobacco products; underage drinking; uptake; young adult

ABSTRACT The primary objective of this study is to identify, describe, and differentiate stable and persistent patterns in trajectories of ENDS use, from 11 to 22 years of age. Seventy percent of adolescent never users will be susceptible to ENDS and other tobacco use by the age of 17 – and, by age 22, in young adulthood, the same proportion will have ever used ENDS or tobacco. Understanding what accelerates this rapid progression in tobacco use behaviors and related outcomes from them (e.g., nicotine dependence) will help inform the development of effective interventions. Considerable controversy exists regarding the role that electronic nicotine delivery systems (ENDS) play in the uptake, progression, and/or cessation of combustible tobacco product use, and appropriate ways to measure and model this. To date, almost all studies of ENDS use behaviors are either cross-sectional or limited to short-term (e.g., 1 year) follow-up, which is inadequate for identifying sustained patterns in ENDS use trajectories across the life course, given that transitions in tobacco use behaviors (i.e., initiation to sustained use or quitting) and between tobacco products (e.g., ENDS and cigarettes) are frequent and erratic. Longer-term studies of patterns in ENDS use trajectories are critical, but they will require additional data collection efforts; especially, regionally. Using a cohort-sequential design, we propose to follow and connect 3 existing, population-based cohorts of adolescents (11-15 years old at Wave 1, 2014-15) through young adulthood (18-22 years old at Wave 14, 2021), to represent developmental changes in ENDS use behaviors across these critical stages in the life course. At Wave 1, during the 2014-15 academic year, the sample included 3,907 (N=461,069) students in the 6th, 8th, and 10th grades in 79 middle schools and high schools (N=1969) in the 4 largest metropolitan areas of Texas: Houston, Dallas/Ft. Worth, San Antonio, and Austin. At Wave 8 (June, 2018), retention remained high, at 85%; the oldest cohort is now 1 year post high school. We propose to follow these cohorts for an additional 6 waves of data collection, every 6 months, to track them all through high school (1, 3, and 5 years post-graduation), into young adulthood. Our web-based surveys include robust measures of ENDS use and other tobacco use behaviors; nicotine dependence; and a broad spectrum of potential risk factors, including intrapersonal, interpersonal, and environmental influences. Growth mixture models shall be applied to these data to empirically identify stable developmental patterns in ENDS use behaviors, from 11 to 22 years of age; we anticipate there will be substantial heterogeneity in them. We will be able to identify young adult outcomes of persistent patterns in ENDS use that begin in adolescence; and risk factors in adolescence that predict ENDS use trajectories that persist into young adulthood. The use of combustible tobacco products in adolescence and young adulthood will be considered, accordingly. Almost all (>95% of) existing cohorts and studies of ENDS use focus on either adolescents or young adults. Very few, like ours, are able to track adolescents into young adulthood to investigate developmental trajectories of risk.

抽象的 这项研究的主要目的是识别，描述和区分稳定和持久的模式 目的轨迹使用的轨迹从11至22岁。 70％的青少年从未用户会 在17岁时容易受到末端和其他烟草的使用 比例将曾经使用过末端或烟草。了解什么加速了这种快速发展 烟草使用行为及其相关结果（例如，尼古丁依赖性）将有助于告知 开发有效的干预措施。关于电子的作用存在很大的争议 尼古丁输送系统（末端）在混合烟草的吸收，进展和/或停止中发挥作用 产品使用以及适当的方法来衡量和建模。迄今为止，几乎所有目的研究都使用 行为是横截面或仅限于短期（例如1年）随访，这是不足的 鉴于烟草中的过渡，确定目的的持续模式使用了整个生活过程中的轨迹 使用行为（即，持续使用或安静的倡议）以及烟草产品之间（例如，末端和 香烟）经常且不稳定。长期对末端模式使用轨迹的研究至关重要，但是 他们将需要其他数据收集工作；特别是区域。使用队列的设计，我们 遵循并连接3个现有的，基于人群的青少年同类的提案 2014-15）至年轻成年（2021年第14波的18-22岁），以代表发育变化 结束在生活过程中使用这些关键阶段的行为。在2014 - 15年度学术期间，在第一波 一年，样本包括79名中学的6、8和10年级的3,907名（n = 461,069）学生 德克萨斯州4个最大的大都市地区的高中（n = 1969）：达拉斯/英尺的休斯顿。沃思，圣安东尼奥， 和奥斯汀。在第8波（2018年6月），保留率仍然很高，为85％；最古老的队列现在高1年 学校。我们建议遵循这些队列，每6个月再收集每6个数据浪潮，以 通过高中（毕业后的1、3和5年）进行全部跟踪，到成年。我们的基于网络的 调查包括最终使用和其他烟草使用行为的强大度量；尼古丁依赖；和 广泛的潜在危险因素，包括人际，人际和环境影响。 生长混合物模型应应用于这些数据，以在经验上确定稳定的发育模式 结束使用行为，从11岁到22岁；我们预计其中将会有很大的异质性。 我们将能够确定青少年开始使用的持续模式的年轻成年结果； 和青少年的危险因素预测末日的使用轨迹，这些轨迹持续到成年。使用 因此，将考虑青少年和年轻成年的可燃烟草产品。几乎全部 （> 95％的）现有队列和目的研究使用的是青少年或年轻人。很少， 像我们一样，能够追踪青少年成年，以研究风险的发展轨迹。