Systems, Pathways and Targets Program (SPT)

系统、途径和目标计划 (SPT)

基本信息

批准号：
10334385
负责人：
John Lowengrub
金额：
$ 4.74万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-09-11 至 2027-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10334385
关键词：
Attention Basic Science Biochemical Pathway Biology Cancer Biology Cancer Center Cancer Center Support Grant Cell Communication Cells Cellular biology Clinical Clinical Investigator Clinical Trials Collaborations Combined Modality Therapy Critical Pathways Dependence Development Diagnostic Disease Doctor of Philosophy Drug resistance Educational workshop Ensure Environment Extramural Activities Faculty Fostering Funding Future Goals Grant Heme Heterogeneity Immunologist Individual Interdisciplinary Study International Intervention Journals Knowledge Laboratory Research Lead Leadership Malignant Neoplasms Metabolic Modeling Neoplasm Metastasis Nutrient Organ Pathway interactions Patients Peer Review Physicians Positioning Attribute Pre-Clinical Model Process Publications Research Research Personnel Research Project Grants Resources Sampling Schools Scientist Signal Transduction Site Statistical Models System Systems Biology Systems Integration Testing Therapeutic Tissue Sample Tissues Transcend Translating Translations Tumor Tissue Validation Work base behavioral study bench to bedside body system cancer cell cancer initiation cell behavior clinical development early-career faculty faculty support fatty acid metabolism innovation inter-institutional interest mathematical model member mevalonate mid-career faculty multidisciplinary neoplastic cell new therapeutic target novel novel diagnostics novel therapeutics pre-clinical research preclinical development programs recruit single cell analysis symposium targeted agent targeted treatment therapeutic target therapy resistant tumor tumor heterogeneity tumor microenvironment tumor progression working group

项目摘要

SYSTEMS, PATHWAYS & TARGETS PROGRAM ABSTRACT/PROJECT SUMMARY The overarching goal of the Systems, Pathways & Targets (SPT) Program is to discover new critical mechanisms of cancer proliferation, survival and drug resistance that can be exploited for the development of novel treatments and diagnostics. SPT members include cell biologists, immunologists, geneticists, systems biologists, computational scientists, and clinicians who leverage diverse perspectives to build collaborative teams that tackle long-standing problems in cancer using bold and innovative approaches. SPT members work at different scales, from molecules and cells to tissues and organs, to study the fundamental biology of individual cancer cells and the interactions among cells in the tumor environment and metastatic sites. Several SPT members are physician-scientists with independent research programs and are well-positioned to translate discoveries from bench to bedside. Moreover, SPT leadership actively connects basic scientists with clinicians through Disease- Oriented Teams (DOTs) and the annual CFCCC Scientific Retreat. These interactions lead to new clinical trials and facilitate access to patient samples for research projects. A unique aspect of SPT is the integration of systems biology approaches to the study of cancer. This emerging emphasis has resulted in productive intra- and inter-programmatic collaborations and extramural funding including a NCI-U54 grant to support a Center in Cancer Systems Biology. SPT maximizes progress toward the identification of targets for cancer therapeutics and diagnostics by devoting resources to recruiting new faculty members, nurturing development of early career faculty, and supporting mid-career faculty members with cutting-edge research programs focused on cancer cell biology and therapeutic targeting. To promote collaboration, SPT supports working groups with shared interests and sponsors conferences and workshops. The Specific Aims of SPT are: to identify key targets in signaling networks, developmental pathways, and metabolic programs that are relevant to cancer initiation, progression, and therapeutic resistance; to support multidisciplinary teams that study how heterogeneity at the single cell level and cell-cell interactions can influence cancer progression and therapeutic resistance; and to enable clinical-basic science multidisciplinary research via DOTs to accelerate the translation of preclinical research. These efforts to discover critical pathways and survival mechanisms will reveal novel therapeutic targets for testing and validation in preclinical models, and eventually in clinical trials. Membership: 72 Members from 16 Departments and 5 Schools Funding: $3,467,881 NCI (Directs); $7,256,055 Other Peer-Reviewed (Directs) Accruals: Interventional: 133; Treatment: 130; Institutional/Investigator-Initiated: 98 Publications: Total: 793; High Impact Journal: 199 (25%); Intra-programmatic: 113 (14%); Inter-Programmatic: 106 (13%); Inter-Institutional: 504 (64%)

系统、途径和目标计划摘要/项目摘要系统、途径和目标 (SPT) 计划的总体目标是发现新的关键机制癌症增殖、存活和耐药性，可用于开发新疗法和诊断。 SPT成员包括细胞生物学家、免疫学家、遗传学家、系统生物学家、计算科学家和临床医生利用不同的观点来建立协作团队使用大胆和创新的方法解决癌症中长期存在的问题。 SPT成员在不同的地方工作从分子和细胞到组织和器官的尺度，研究个体癌症的基础生物学细胞以及肿瘤环境和转移部位中细胞之间的相互作用。多名 SPT 成员是拥有独立研究项目的医师科学家，能够很好地转化来自长凳到床边。此外，SPT 领导层通过疾病积极地将基础科学家与临床医生联系起来。定向团队 (DOT) 和年度 CFCC 科学务虚会。这些相互作用导致新的临床试验并促进研究项目获取患者样本。 SPT 的一个独特之处是集成了研究癌症的系统生物学方法。这种新兴的重点导致了富有成效的内部以及跨项目合作和校外资助，包括 NCI-U54 赠款，用于支持一个中心癌症系统生物学。 SPT 最大限度地促进癌症治疗靶点的识别通过投入资源招聘新教员、培育早期职业发展来进行诊断教师，并通过专注于癌细胞的尖端研究项目为职业生涯中期的教师提供支持生物学和治疗靶向。为了促进协作，SPT 支持工作组共享兴趣并赞助会议和研讨会。 SPT 的具体目标是：确定关键目标与癌症发生相关的信号网络、发育途径和代谢程序，进展和治疗抵抗；支持多学科团队研究异质性如何单细胞水平和细胞间相互作用可以影响癌症进展和治疗耐药性；并到通过 DOT 实现临床基础科学多学科研究，加速临床前研究成果的转化研究。这些发现关键途径和生存机制的努力将揭示新的治疗方法在临床前模型中以及最终在临床试验中进行测试和验证的目标。会员：来自 16 个部门和 5 个学校的 72 名会员资金：3,467,881 美元 NCI（直接）； $7,256,055 其他同行评审（直接）应计费用：介入：133；治疗：130；机构/研究者发起：98 出版物：总计：793；高影响力期刊：199 (25%)；程序内：113 (14%)；程序间：106 (13%)；机构间：504 (64%)