Discovery of Novel Antibiotic Natural Products from Marine-Derived Fungi

从海洋衍生真菌中发现新型抗生素天然产物

基本信息

批准号：
10333784
负责人：
Erin Patricia McCauley
金额：
$ 14.7万
依托单位：
CALIFORNIA STATE UNIV-DOMINGUEZ HILLS
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-25 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10333784
关键词：
Antibiotic Resistance Antibiotics Area Bacteria Bar Codes Bioinformatics Biological Biological Assay Biomedical Research California Cell Wall Cells Chemicals Collaborations Databases Development Disease Exhibits Foundations Future Genes Goals Growth Habitats Health Hispanic-serving Institution Host Defense Human Libraries Mammals Methods Modern Medicine Natural Products Needles Organism Phylogenetic Analysis Phylogeny Play Proteins Publishing Recovery Research Resistance Role Sampling Source Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Students Taxonomy Techniques Therapeutic Time Traditional Medicine Type III Secretion System Pathway Universities Virulence Virulence Factors World Health Organization bactericide base bioactive natural products combat commensal bacteria data acquisition drug development drug discovery fungus innovation marine natural product microbial novel pathogen pathogenic bacteria priority pathogen programs scaffold screening small molecule therapeutic development

Antibiotic Resistance Antibiotics Area Bacteria Bar Codes Bioinformatics Biological Biological Assay Biomedical Research California Cell Wall Cells Chemicals Collaborations Databases Development Disease Exhibits Foundations Future Genes Goals Growth Habitats Health Hispanic-serving Institution Host Defense Human Libraries Mammals Methods Modern Medicine Natural Products Needles Organism Phylogenetic Analysis Phylogeny Play Proteins Publishing Recovery Research Resistance Role Sampling Source Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Students Taxonomy Techniques Therapeutic Time Traditional Medicine Type III Secretion System Pathway Universities Virulence Virulence Factors World Health Organization bactericide base bioactive natural products combat commensal bacteria data acquisition drug development drug discovery fungus innovation marine natural product microbial novel pathogen pathogenic bacteria priority pathogen programs scaffold screening small molecule therapeutic development

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项目摘要

Project Summary/Abstract A major challenge facing the future of human health is the rise of antibiotic-resistant pathogenic bacteria. In 2017 the World Health Organization (WHO) published a list of twelve pathogens that will pose the greatest threat to human health due to resistance to frontline treatments. The overall goal of this project will be to identify novel fungal natural products that exhibit antibiotic activity towards the WHO pathogens. Natural products are secondary metabolites produced by living organisms. These small molecule chemical entities have played an important role in traditional medicine for thousands of years and are an essential part of the current therapeutic arsenal for modern medicine. This project will achieve the overall goal through two areas of research. The first area involves the development of a rapid dereplication method that reduces redundant fungal strains in culture libraries to streamline biological screening. The second involves the identification of antibiotic drug-leads with novel chemical scaffolds or that function through a unique antivirulence mechanism of action against the WHO pathogens. Once completed, these two areas of research will be bridged to develop a fungal metabolite drug discovery platform that will be used to promote future lines of biomedical research.

项目摘要/摘要人类健康未来面临的一个重大挑战是抗生素抗生素的致病细菌的兴起。 2017年世界卫生组织（WHO）出版了十二种病原体清单，这些病原体将对由于对一线治疗的抵抗，人类健康。该项目的总体目标是确定小说对WHO病原体表现出抗生素活性的真菌天然产品。天然产品是生物生物产生的次生代谢产物。这些小分子化学实体发挥了数千年来在传统医学中的重要作用，是当前治疗的重要组成部分现代医学的阿森纳。该项目将通过两个研究领域实现总体目标。第一个区域涉及开发一种快速的消除方法，该方法可降低培养物中冗余的真菌菌株简化生物学筛查的库。第二个涉及鉴定与新型的化学支架或该功能通过针对世卫组织的独特抗动力机理病原体。完成后，这两个研究领域将被桥接以开发真菌代谢物药物发现平台将用于促进未来的生物医学研究线。