Integrated Genomics Operations

综合基因组学操作

• 批准号: 10319513
• 负责人: Agnes Viale
• 金额: $ 76.08万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-20 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10319513
• 关键词: Base Sequence; Basic Science; Bioinformatics; Biological Assay; Cancer Center; Cancer Center Support Grant; Cells; Chromosome Structures; Clinical Research; Consultations; Custom; DNA; DNA analysis; Data; Data Analyses; Environment; Experimental Designs; Gene Expression; Genomics; Grant; High-Throughput Nucleotide Sequencing; Informatics; Journals; Libraries; Metadata; Organism; Paraffin; Pathology; Preparation; Price; Process; Production; Publications; Publishing; RNA; Research Personnel; Research Project Grants; Research Support; Sampling; Scientist; Serum; Services; Software Engineering; System; Technology; Time; Tissues; Translational Research; Tumor Bank; Work; cost effective; data management; design; frontier; functional genomics; genomic data; human cancer mouse model; human data; interest; member; operation; programs; tumor; user-friendly; wasting

ABSTRACT The Integrated Genomics Operation (IGO) Core provides a broad range of services and expertise to Center investigators interested in evaluating gene expression, chromosome structure, and nucleotide sequence on a broad scale. It delivers a comprehensive, rapid, and user-friendly service. IGO enables basic, clinical, and translational research projects across the Center. Through the centralized management of all sequencing activities at MSK, the Core empowers scientists with an array of technological options and the most efficient and cost-effective means of performing high-throughput genomics. Through its production group, the Core supports most functional genomics applications for analysis of DNA and RNA and has the expertise to successfully process challenging samples from all origins (tissue, cell pellets, paraffin curls, blood, serum, etc.). This expertise is particularly important for investigators studying heterogenous tumor types from the MSK tumor bank. If needed, this group can operate in a highly automated environment, from sample reception to sequencing library preparation. The production group is a LEAN operation that minimizes waste and maximizes value at every step. Consequently, turnaround times and prices are competitive with those offered by commercial and other academic entities. The IGO also provides a customized service to investigators wishing to explore new frontiers in applications and technologies. The Informatics group of the Core provides end-to-end software engineering and bioinformatic analysis solutions to the users of its sequencing services. The broad range of services provided by the IGO Core has supported research of 377 investigators in the past year. During the past grant period, the work of the Core has contributed to 882 publications across all programs; 237 of these publications were published in high impact journals.

抽象的 综合基因组操作（IGO）核心为中心提供广泛的服务和专业知识 有兴趣评估基因表达，染色体结构和核苷酸序列的研究者 大规模。它提供全面，快速且用户友好的服务。 Igo启用基本，临床和 整个中心的翻译研究项目。通过所有测序的集中管理 在MSK的活动，核心使科学家拥有一系列技术选择和最有效的科学家 以及进行高通量基因组学的成本效益手段。 通过其生产组，核心支持大多数功能基因组学应用DNA分析 RNA和RNA具有专业知识，可以成功处理所有起源（组织，细胞）的挑战性样本 颗粒，石蜡卷曲，血液，血清等）。这种专业知识对于研究的调查人员尤其重要 来自MSK肿瘤库的异质肿瘤类型。如果需要，该组可以在高度自动化中运行 环境，从样本接收到测序文库的准备。生产小组是一个精益 操作可以最大程度地减少浪费并在每个步骤中最大化价值。因此，周转时间和价格 与商业和其他学术实体提供的竞争力。 Igo还提供了 为希望探索应用和技术领域的新领域的调查人员定制服务。这 核心的信息小组提供了端到端的软件工程和生物信息学分析解决方案 其排序服务的用户。 Igo Core提供的广泛服务曾支持377名调查人员的研究 年。在过去的赠款期间，核心的工作为所有人贡献了882个出版物 程序；这些出版物中有237个发表在高影响期刊上。