Non-Contrast-Enhanced Velocity-Selective MR Angiography at 3T for Cerebrovascular Diseases

3T 非对比增强速度选择性 MR 血管造影治疗脑血管疾病

基本信息

批准号：
10312022
负责人：
Qin Qin
金额：
$ 40.4万
依托单位：
HUGO W. MOSER RES INST KENNEDY KRIEGER
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-12-15 至 2023-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10312022
关键词：
3-Dimensional Aftercare Aneurysm Angiography Arteries Arteriographies Arteriovenous fistula Arteriovenous malformation Blood Blood Vessels Blood flow Bolus Infusion Brain Carotid Stenosis Catheters Cause of Death Cerebral Angiography Cerebrovascular Disorders Cerebrum Child Clinical Contrast Media Deposition Diabetes Mellitus Diagnosis Diagnostic Differential Diagnosis Digital Subtraction Angiography Economic Burden Evaluation Fourier Transform Gadolinium Gold Head Immunity Impairment Injections Intracranial Arterial Stenosis Intracranial Sinus Thrombosis Ionizing radiation Kidney Diseases Label Life Magnetic Resonance Angiography Magnetic Resonance Imaging Methods Monitor Motion Nephrogenic Systemic Fibrosis Neurologic Organ Patients Performance Phase Phlebography Physiologic pulse Play Pregnant Women Prognosis Protocols documentation Radiation exposure Radiology Specialty Reading Renal function Reporting Resolution Rest Roentgen Rays Role Safety Scanning Scheme Signal Transduction Societies Stenosis Stroke Techniques Therapeutic Time Tissues Training Vascular Diseases Venous Visualization X-Ray Computed Tomography arterial spin labeling base cerebrovascular clinical examination clinical practice clinically relevant contrast enhanced cost design disability follow-up healthy volunteer imaging modality intracranial artery novel preservation risk minimization screening social soft tissue venous sinus

项目摘要

Project Abstract Cerebrovascular diseases, as one of the leading causes of death and disability in all societies, impose enormous social-economic burden worldwide. Cerebral angiography plays an indispensable role in differential diagnosis, prognosis outlook, therapeutic management, and follow-up after treatment for patients with neurological vasopathology, such as stroke, arterial stenosis, cerebral venous sinus thrombosis , arteriovenous malformation, and aneurysm. Traditionally, catheter-based X-ray angiography has been considered the gold standard for cerebrovascular assessment. Contrast-enhanced (CE) MRA allows large spatial coverage, high spatial resolution, and rapid acquisition. However, arterial visualization are often obscured by venous enhancement. In addition, the safety of Gd based CE MRA has been challenged for the concerns of developing Nephrogenic Systemic Fibrosis (NSF) for patients with impaired kidney function and the reports of Gd deposition in the brain even when no kidney disease is present . Thus non-contrast-enhanced MR angiography (NCE MRA) has rapidly evolved to minimize risk and lower cost. The primary NCE cerebral MRA in clinical practice is the 3D time-of- flight (TOF) method, which is known to have limited angiographic coverage and poor delineation of slow flow. Newly developed arterial spin labeling (ASL) MRA can provide either large spatial coverage or 4D time-resolved MRA with dynamic filling of arteries. The drawback of the ASL methods are the reduced signal efficiency, lengthened scan times due to the required two acquisitions for subtraction of labeled and unlabeled blood signal, and sensitivity to motion-induced misregistration. We recently demonstrated feasibility of a novel velocity- selective (VS) MRA approach for cerebral applications at 3T, which is a non-subtractive technique and allows large coverage and slow-flow depiction. Aiming to incorporate favorable aspects of both TOF and ASL MRA methods, we propose numerous technical advances for VS MRA to render 3D arteriography, venography and 4D time-resolved MRA. The purpose of this study is first to further develop these VS cerebral MRA techniques in flow phantoms and healthy subjects (Aim 1), then to evaluate the 3D VS MR arteriography in patients with carotid or intracranial stenosis (Aim 2) and the 3D VS MR venography in patients with cerebral venous sinus thrombosis (Aim 3), and finally to evaluate the 4D time-resolved VS-MRA in patients with AVM or aneurysm (Aim 4). The proposed NCE VS MRA techniques are expected to show clinical values not only for the brain, but also for the rest of the body, and especially benefit children, pregnant women, and patients with diabetes or impaired kidney function .

项目摘要脑血管疾病是所有社会中死亡和残疾的主要原因之一，施加了巨大的全球社会经济负担。脑血管造影在鉴别诊断中起着必不可少的作用，预后前景，治疗管理和治疗后的随访患者血管病理学，例如中风，动脉狭窄，脑静脉窦血栓形成，动静脉畸形，和动脉瘤。传统上，基于导管的X射线血管造影被认为是金标准脑血管评估。对比增强（CE）MRA允许大型空间覆盖，高空间解决方案和快速获取。但是，静脉增强通常会掩盖动脉可视化。在此外，基于GD的CE MRA的安全性受到肾病的关注而受到质疑针对肾功能受损患者的全身纤维化（NSF）大脑中的GD沉积即使没有肾脏疾病。因此，非对抗增强的MR血管造影（NCE MRA）的迅速进化以最大程度地降低风险和较低的成本。临床实践中的主要NCE脑MRA是3D时间飞行方法（TOF）方法，该方法的血管造影覆盖率有限，缓慢流动的描述差。新开发的动脉自旋标记（ASL）MRA可以提供大空间覆盖范围或4D时间分辨 MRA充满动脉填充动脉。 ASL方法的缺点是信号效率降低，由于所需的两次采集来减去标记和未标记的血液信号，扫描时间延长，以及对运动引起的误导的敏感性。我们最近证明了新型速度的可行性 - 在3T处进行脑应用的选择性（VS）MRA方法，这是一种非提取技术，允许大覆盖范围和慢速描绘。旨在纳入TOF和ASL MRA的有利方面方法，我们建议对MRA进行许多技术进步，以使3D动脉造影，静脉曲张和 4D时间分辨MRA。这项研究的目的是首先要进一步开发这些与脑MRA技术在流量幻象和健康受试者中（AIM 1），然后评估3D与MR动脉造影的患者颈内狭窄或颅内狭窄（AIM 2）和3D与MR静脉血栓形成（AIM 3），最后评估AVM或动脉瘤患者的4D时间分辨VS-MRA （目标4）。拟议的NCE与MRA技术有望显示出对大脑的临床值，而且还会显示也适用于身体的其余部分，尤其是受益儿童，孕妇和糖尿病患者或肾功能受损。

项目成果

期刊论文数量（16）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Test-retest reliability of 3D velocity-selective arterial spin labeling for detecting normal variations of cerebral blood flow.

DOI：
10.1016/j.neuroimage.2023.120039
发表时间：
2023-05-01
期刊：
NEUROIMAGE
影响因子：
5.7
作者：
Xu, Feng;Liu, Dapeng;Zhu, Dan;Hillis, Argye E.;Bakker, Arnold;Soldan, Anja;Albert, Marilyn S.;Lin, Doris D. M.;Qin, Qin
通讯作者：
Qin, Qin

Prostate perfusion mapping using Fourier-transform based velocity-selective arterial spin labeling: Choice of cutoff velocity and comparison with brain.

使用基于傅里叶变换的速度选择性动脉自旋标记进行前列腺灌注图：截止速度的选择并与大脑进行比较。

DOI：
10.1002/mrm.29695
发表时间：
2023
期刊：
Magnetic resonance in medicine
影响因子：
3.3
作者：
Liu,Dapeng;Zhu,Dan;Xu,Feng;Sedaghat,Farzad;Qin,Qin
通讯作者：
Qin,Qin

A revisit of the k-space filtering effects of magnetization-prepared 3D FLASH and balanced SSFP acquisitions: Analytical characterization of the point spread functions.

DOI：
10.1016/j.mri.2022.01.015
发表时间：
2022-05
期刊：
Magnetic resonance imaging
影响因子：
2.5
作者：
Zhu D;Qin Q
通讯作者：
Qin Q

Velocity-selective arterial spin labeling perfusion MRI: A review of the state of the art and recommendations for clinical implementation.

DOI：
10.1002/mrm.29371
发表时间：
2022-10
期刊：
MAGNETIC RESONANCE IN MEDICINE
影响因子：
3.3
作者：
Qin, Qin;Alsop, David C.;Bolar, Divya S.;Hernandez-Garcia, Luis;Meakin, James;Liu, Dapeng;Nayak, Krishna S.;Schmid, Sophie;van Osch, Matthias J. P.;Wong, Eric C.;Woods, Joseph G.;Zaharchuk, Greg;Zhao, Moss Y.;Zun, Zungho;Guo, Jia
通讯作者：
Guo, Jia

Magnetic resonance angiography and perfusion mapping by arterial spin labeling using Fourier transform-based velocity-selective pulse trains: Examination on a commercial perfusion phantom.