Recovering Individual Memory Problems Histories from Own and Proxy Retrospective Reports: A Feasibility Study

从自己和代理人的回顾报告中恢复个人记忆问题的历史：可行性研究

• 批准号: 10288967
• 负责人: Dean R Lillard
• 金额: $ 25.09万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-11 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10288967
• 关键词: Address; Aging; Algorithms; Alzheimer' s disease diagnosis; Alzheimer' s disease related dementia; Biological Markers; Brain; Calendar; Cells; Characteristics; China; Communities; Complement; Country; Cross-Sectional Studies; Data; Data Reporting; Dementia; Diabetes Mellitus; Diagnosis; Disadvantaged; Disease; Education; Elderly; Europe; Event; Evolution; Exercise; Feasibility Studies; Funding; Goals; Gold; Government; Health; Health Surveys; Health and Retirement Study; Household; Impaired cognition; Incidence; Individual; International; Investments; Life; Life Cycle Stages; Literature; Longitudinal Studies; Longitudinal Surveys; Measurement; Measures; Memory; Memory Loss; Methods; Modeling; National Health Interview Survey; Obesity; Pathologic; Patient Self-Report; Patients; Persons; Population; Prevalence; Proxy; Recording of previous events; Reporting; Research Personnel; Respondent; Retirement; Sampling; Source; Stroke; Structure; Surveys; Symptoms; Visiting Nurse; Work; aging demographic; aging population; base; design; health data; insight; interest; life history; nutrition; panel study of income dynamics; parent project; predictive test; success

Project Summary In the project, "Recovering Individual Memory Problems Histories from Own and Proxy Retrospective Reports: A Feasibility Study," we will adapt and extend the well-known Langa- Weir method to estimate the prevalence of Alzheimer’s Disease and Related Dementias (ADRD) over the life-course of individuals. Our aims are explore whether and under what conditions one can use that method to identify incipient ADRD in earlier life stages and how well the method works. We focus specifically on ADRD not only because it is a critical issue faced by most of the world’s populations but also because it is part of a class of diseases that share two important features. First, in early stages of ADRD, patients present symptoms that are difficult to interpret and that might be caused by multiple and very different diseases. Second, after a person clearly has ADRD, that person increasingly finds it more and more difficult to remember and report whether and when their symptoms began. The first characteristic implies that, compared to contemporaneously collected data, retrospectively reported data might better measure prevalence in populations at the early stages of ADRD. The second characteristic implies that self-reported retrospective data will likely be less accurate than retrospective reports of proxy respondents (who know the respondent’s history). Our project leverages, complements, and benefits from the approach, data, and structure in our recently funded R21 project titled, “Constructing, Validating, and Testing the Predictive Power of Life-Course Health Histories.” In particular we will use the life course histories of other diseases as covariates in our model to predict incipient ADRD. This supplemental project will dive more deeply into the specific issues associated with ADRD. As in the parent project, our overall aims are to conduct a “proof-of- concept” exercise to explore whether and for what conditions one can use retrospective questions to generate life health histories and to provide a guide for researchers to use. Our work products will expand the set of questions researchers can address with retrospective health data already collected on existing surveys. The supplemental project will yield insights on the specific issues associated with ADRD.

项目概要 在该项目中，“从自己和代理恢复个人记忆问题历史” 回顾性报告：可行性研究”，我们将改编并扩展著名的 Langa- 威尔法估计阿尔茨海默病和相关痴呆症的患病率 （ADRD）在个人的生命历程中我们的目标是探索是否以及在什么情况下。 人们可以使用该方法来识别生命早期阶段的早期 ADRD 以及其效果如何 我们特别关注 ADRD，不仅因为它是一个面临的关键问题。 世界上大多数人口都患有这种疾病，而且还因为它是一类具有两种共同特征的疾病的一部分 首先，在 ADRD 的早期阶段，患者会出现难以察觉的症状。 其次，这可能是由多种不同的疾病引起的。 一个人明显患有ADRD，这个人越来越发现它越来越难以记住 并报告他们的症状是否以及何时开始。第一个特征意味着， 与同时收集的数据相比，回顾性报告的数据可能更好 测量 ADRD 早期阶段人群的患病率。 意味着自我报告的回顾性数据可能不如回顾性报告准确 我们的项目利用、补充、 并受益于我们最近资助的 R21 项目的方法、数据和结构， “构建、验证和测试生命历程健康史的预测能力。” 特别是，我们将使用其他疾病的生命历程作为模型中的协变量来 预测初期的 ADRD。这个补充项目将更深入地探讨具体问题。 与 ADRD 相关，与父项目一样，我们的总体目标是进行“证明- 概念”练习探索是否以及在什么条件下可以使用回顾性 问题来生成生活健康史并为研究人员提供使用指南。 工作产品将扩大研究人员可以回顾性解决的一系列问题 补充项目将产生有关现有调查的健康数据的见解。 与 ADRD 相关的具体问题。