Purchase of a high-density electroencephalography (EEG) and neuromodulation system for use in an institutional core facility

购买高密度脑电图 (EEG) 和神经调节系统用于机构核心设施

• 批准号: 10283029
• 负责人: MUSTAFA SAHIN
• 金额: $ 48.44万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10283029
• 关键词: Anxiety; Applications Grants; Attention deficit hyperactivity disorder; Biological Markers; Boston; Child; Childhood; Collection; Core Facility; Data; Disease; Electroencephalography; Equipment; Event-Related Potentials; Experimental Designs; Funding; Galvanic Skin Response; Goals; Heart Rate; Human; Infant; Magnetic Resonance Imaging; Measures; Mental Health; National Institute of Mental Health; Neurophysiology - biologic function; Outcome; Pediatric Hospitals; Physiological; Physiology; Population; Psychotic Disorders; Reproducibility; Request for Applications; Research; Research Personnel; Standardization; Stratification; System; Technical Expertise; Techniques; Technology; Therapeutic; Transcranial magnetic stimulation; Validation; autism spectrum disorder; base; density; design; flexibility; improved; neurofeedback; neurophysiology; neuropsychiatric disorder; neuropsychiatry; neuroregulation; prognostic; psychotic depression; research study; symptomatology; treatment response; Anxiety; Applications Grants; Attention deficit hyperactivity disorder; Biological Markers; Boston; Child; Childhood; Collection; Core Facility; Data; Disease; Electroencephalography; Equipment; Event-Related Potentials; Experimental Designs; Funding; Galvanic Skin Response; Goals; Heart Rate; Human; Infant; Magnetic Resonance Imaging; Measures; Mental Health; National Institute of Mental Health; Neurophysiology - biologic function; Outcome; Pediatric Hospitals; Physiological; Physiology; Population; Psychotic Disorders; Reproducibility; Request for Applications; Research; Research Personnel; Standardization; Stratification; System; Technical Expertise; Techniques; Technology; Therapeutic; Transcranial magnetic stimulation; Validation; autism spectrum disorder; base; density; design; flexibility; improved; neurofeedback; neurophysiology; neuropsychiatric disorder; neuropsychiatry; neuroregulation; prognostic; psychotic depression; research study; symptomatology; treatment response

ABSTRACT This grant application requests funding for the purchase of a high-density electroencephalography (EEG) system to reside in the Human Neurophysiology Core at Boston Children's Hospital. The EEG system offers state-of- the-art technology that will allow investigators flexibility in experimental design to incorporate event related potentials, magnetic resonance imaging (MRI) co-acquisition, transcranial magnetic stimulation (TMS) application and physiology co-registering into high density EEG collection. The equipment selected has been optimized for EEG biomarker collection in pediatric populations, including infants, young children, children with neurodevelopmental delays and neuropsychiatric symptomatology. Importantly, the equipment will be located within a Core facility staffed with experts in the design, collection and analysis of EEG data enabling users to obtain impactful results related to a broad array of NIMH funded research aims. EEG is being incorporated into an increasing number of research studies due to the capacity of this technique to yield high quality data reflecting neural function and connectivity from sensitive populations. Biomarkers of disease state, prognostics, stratification and treatment response have been identified in a number of neuropsychiatric disorders including autism spectrum disorder, ADHD, psychotic disorders and depression/anxiety. Furthermore, considerable EEG research is being undertaken specifically for therapeutic indications in combination with physiological measures (heart rate, galvanic skin response), TMS and MRI neuro- feedback. The realization of these research goals, however, is dependent on the collection of standardized, reproducible data, which is dependent on high quality equipment with built-in validation capabilities and deep technical expertise. To this end, availability of the state-of-the art equipment outlined here within a core setting makes incorporation of EEG based biomarkers and therapeutic applications possible for all investigators focused on improving mental health outcomes.

抽象的 该赠款申请要求购买高密度脑电图（EEG）系统的资金 居住在波士顿儿童医院的人类神经生理学核心。 EEG系统提供 ART技术将允许研究人员灵活地进行实验设计，以合并有关事件 电势，磁共振成像（MRI）共同进取，经颅磁刺激（TMS） 应用和生理共同注册到高密度脑电图收集中。选定的设备已经 针对儿科人群中的EEG生物标志物收集优化，包括婴儿，幼儿，患有儿童 神经发育延迟和神经精神症状学。重要的是，设备将位于 在核心设施中，由脑电图数据的设计，收集和分析专家组成，使用户能够 获得与广泛的NIMH资助研究目的有关的有影响力的结果。 由于该技术的能力，EEG正在纳入越来越多的研究中 产生反映敏感人群的神经功能和连通性的高质量数据。生物标志物 疾病状态，预后，分层和治疗反应已在许多中鉴定 神经精神疾病，包括自闭症谱系障碍，多动症，精神病疾病和 抑郁/焦虑。此外，正在专门为治疗而进行大量脑电图研究 结合生理措施（心率，电流皮肤反应），TMS和MRI神经 - 反馈。但是，这些研究目标的实现取决于标准化的收集， 可再现数据，该数据取决于具有内置验证功能和深度的高质量设备 技术专长。为此，在核心环境中概述的最新设备的可用性 使所有专注的研究人员都可以纳入基于EEG的生物标志物和治疗应用 关于改善心理健康结果。