Objective Measures of Intraocular Inflammation in Pediatric Anterior Uveitis

小儿前葡萄膜炎眼内炎症的客观测量

• 批准号: 10283026
• 负责人: Edmund Tsui
• 金额: $ 24.66万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10283026
• 关键词: Adult; Algorithms; Anterior; Anterior uveitis; Arthritis; Award; Biometry; Blindness; California; Cells; Child; Childhood; Chronic; Clinical; Clinical Research; Clinical Trials; Control Groups; Cross-Sectional Studies; Detection; Development; Diagnosis; Disease; Early Diagnosis; Ensure; Epidemiology; Evaluation; Eye; Eye Development; Flare; Goals; Grant; Image; Image Analysis; Immunosuppressive Agents; Inflammation; Institutes; K-Series Research Career Programs; Lasers; Lead; Learning; Longitudinal Studies; Longitudinal prospective study; Los Angeles; Master of Science; Measurement; Measures; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methods; Modeling; Monitor; Nomenclature; Onset of illness; Ophthalmology; Optical Coherence Tomography; Outcome; Patient Recruitments; Patients; Pediatrics; Periodicity; Photometry; Play; Proteins; Reproducibility; Research; Research Personnel; Rheumatology; Risk; Role; Scanning; Scientist; Specialist; Standardization; Symptoms; System; Techniques; Time; Toxic effect; Training; Universities; Uveitis; Vision; Vision Disorders; Visual; anterior chamber; base; clinical practice; clinical trial implementation; design; disability; high risk; image processing; improved; instrument; multidisciplinary; patient oriented; patient oriented research; preservation; prevent; professor; research clinical testing; risk stratification; routine screening; screening; slit lamp imaging; treatment response; vision development; working group; Adult; Algorithms; Anterior; Anterior uveitis; Arthritis; Award; Biometry; Blindness; California; Cells; Child; Childhood; Chronic; Clinical; Clinical Research; Clinical Trials; Control Groups; Cross-Sectional Studies; Detection; Development; Diagnosis; Disease; Early Diagnosis; Ensure; Epidemiology; Evaluation; Eye; Eye Development; Flare; Goals; Grant; Image; Image Analysis; Immunosuppressive Agents; Inflammation; Institutes; K-Series Research Career Programs; Lasers; Lead; Learning; Longitudinal Studies; Longitudinal prospective study; Los Angeles; Master of Science; Measurement; Measures; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methods; Modeling; Monitor; Nomenclature; Onset of illness; Ophthalmology; Optical Coherence Tomography; Outcome; Patient Recruitments; Patients; Pediatrics; Periodicity; Photometry; Play; Proteins; Reproducibility; Research; Research Personnel; Rheumatology; Risk; Role; Scanning; Scientist; Specialist; Standardization; Symptoms; System; Techniques; Time; Toxic effect; Training; Universities; Uveitis; Vision; Vision Disorders; Visual; anterior chamber; base; clinical practice; clinical trial implementation; design; disability; high risk; image processing; improved; instrument; multidisciplinary; patient oriented; patient oriented research; preservation; prevent; professor; research clinical testing; risk stratification; routine screening; screening; slit lamp imaging; treatment response; vision development; working group

PROJECT SUMMARY Anterior uveitis is the most common form of intraocular inflammation in children. Children tend to have more chronic courses than adults and thus require more frequent examinations for screening and monitoring of inflammation. Clinical grading of anterior chamber (AC) inflammation, both cell and flare, is currently performed at the slit lamp utilizing the widely accepted Standardization of Uveitis Nomenclature (SUN) Working Group criteria. However, this system has limitations since it is non-continuous and semi-quantitative. A rapid, reproducible, and quantitative technique to evaluate inflammation is of paramount importance in children as they are often unable to cooperate with prolonged examination at the slit lamp. This K23 Mentored Patient-Oriented Career Development Award proposal seeks to evaluate objective measures of intraocular inflammation to improve the diagnosis and monitoring of anterior uveitis in children. This award will provide Dr. Edmund Tsui, a uveitis specialist and Assistant Professor at the Stein Eye Institute at the University of California, Los Angeles, with the protected research time and formal coursework towards a Master’s of Science in Clinical Research to establish himself as an investigator in patient-oriented research in uveitis. This award will provide Dr. Tsui with the support to achieve the following goals: 1) to learn biostatistics and epidemiology, 2) to become skilled at image acquisition, processing and analysis, 3) to learn about the design and implementation of clinical trials. Dr. Tsui has assembled an outstanding multi-disciplinary team of mentors to ensure that he will achieve these goals. His mentorship team consists of Dr. Gary N. Holland (Professor of Ophthalmology and an expert in pediatric uveitis), Dr. Srinivas R. Sadda (Professor of Ophthalmology and a world-leader in ophthalmic image processing and analysis), and Dr. Deborah K. McCurdy (Professor of Pediatrics, Division of Pediatric Rheumatology and an expert in pediatric arthritis). We will pursue the following specific aims: 1) develop a standardized, reproducible technique using anterior- segment optical coherence tomography to quantify AC cells, 2) longitudinally evaluate AC flare using laser flare photometry, and 3) create a predictive risk stratification model based on objective measures of intraocular inflammation. The long-term goal is that these results would support the use of objective measures in routine clinical practice and as endpoints in clinical trials. Ultimately, earlier detection and improved monitoring of uveitis in children can prevent permanent vision loss and disability. This research will lead to the submission of an R01 grant prior to the end of the K23 award to enable Dr. Tsui to become an independent clinician-scientist.

项目摘要 葡萄膜炎是儿童眼内炎症的最常见形式。孩子们往往有更多 慢性课程比成年人，因此需要更频繁的检查以筛查和监测 炎。目前正在进行前腔（AC）炎症的临床分级（AC）炎症 在缝隙灯处使用广泛接受的葡萄膜炎命名法（Sun）工作组的标准化 标准。但是，该系统具有局限性，因为它是非连续和半定量性的。快速 在儿童中，可再现和定量技术评估炎症至关重要 他们通常无法在缝隙灯时长时间检查。 这项K23指导的以患者为导向的职业发展奖提案旨在评估目标 眼内炎症的措施，以改善儿童前葡萄膜炎的诊断和监测。 该奖项将为斯坦因眼科研究所的葡萄膜炎专家兼助理教授Edmund Tsui博士提供 在加利福尼亚大学洛杉矶分校，受到保护的研究时间和正式课程 临床研究硕士学位，以确立自己的研究人员 葡萄膜炎。该奖项将为TSUI博士提供支持以实现以下目标的支持：1）学习生物统计学 和流行病学，2）在图像获取，处理和分析方面熟练，3）了解 临床试验的设计和实施。 TSUI博士组建了一个杰出的多学科团队 指导者确保他将实现这些目标。他的指导团队由加里·N·荷兰博士组成 （眼科教授和小儿葡萄膜炎的专家），Srinivas R. Sadda博士（教授 眼科和眼科处理和分析中的世界领导者）和Deborah K. McCurdy（小儿风湿病学儿科教授和儿科关节炎专家）。 我们将追求以下具体目的：1）使用前部开发标准化的，可重复的技术 段光学相干断层扫描以量化AC细胞，2）使用激光纵向评估AC耀斑 耀斑光度法和3）基于眼内的客观测量，创建一个预测风险分层模型 炎。长期目标是这些结果将支持在常规中使用客观措施 临床实践和临床试验中的终点。最终，较早的检测和改进了对 儿童的葡萄膜炎可以防止永久视力丧失和残疾。这项研究将导致提交 在K23奖励结束之前，是R01赠款，以使TSUI博士成为独立的临床科学家。