Objective Measures of Intraocular Inflammation in Pediatric Anterior Uveitis

小儿前葡萄膜炎眼内炎症的客观测量

• 批准号: 10283026
• 负责人: Edmund Tsui
• 金额: $ 24.66万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10283026
• 关键词: Adult; Algorithms; Anterior; Anterior uveitis; Arthritis; Award; Biometry; Blindness; California; Cells; Child; Childhood; Chronic; Clinical; Clinical Research; Clinical Trials; Control Groups; Cross-Sectional Studies; Detection; Development; Diagnosis; Disease; Early Diagnosis; Ensure; Epidemiology; Evaluation; Eye; Eye Development; Flare; Goals; Grant; Image; Image Analysis; Immunosuppressive Agents; Inflammation; Institutes; K-Series Research Career Programs; Lasers; Lead; Learning; Longitudinal Studies; Longitudinal prospective study; Los Angeles; Master of Science; Measurement; Measures; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methods; Modeling; Monitor; Nomenclature; Onset of illness; Ophthalmology; Optical Coherence Tomography; Outcome; Patient Recruitments; Patients; Pediatrics; Periodicity; Photometry; Play; Proteins; Reproducibility; Research; Research Personnel; Rheumatology; Risk; Role; Scanning; Scientist; Specialist; Standardization; Symptoms; System; Techniques; Time; Toxic effect; Training; Universities; Uveitis; Vision; Vision Disorders; Visual; anterior chamber; base; clinical practice; clinical trial implementation; design; disability; high risk; image processing; improved; instrument; multidisciplinary; patient oriented; patient oriented research; preservation; prevent; professor; research clinical testing; risk stratification; routine screening; screening; slit lamp imaging; treatment response; vision development; working group

PROJECT SUMMARY Anterior uveitis is the most common form of intraocular inflammation in children. Children tend to have more chronic courses than adults and thus require more frequent examinations for screening and monitoring of inflammation. Clinical grading of anterior chamber (AC) inflammation, both cell and flare, is currently performed at the slit lamp utilizing the widely accepted Standardization of Uveitis Nomenclature (SUN) Working Group criteria. However, this system has limitations since it is non-continuous and semi-quantitative. A rapid, reproducible, and quantitative technique to evaluate inflammation is of paramount importance in children as they are often unable to cooperate with prolonged examination at the slit lamp. This K23 Mentored Patient-Oriented Career Development Award proposal seeks to evaluate objective measures of intraocular inflammation to improve the diagnosis and monitoring of anterior uveitis in children. This award will provide Dr. Edmund Tsui, a uveitis specialist and Assistant Professor at the Stein Eye Institute at the University of California, Los Angeles, with the protected research time and formal coursework towards a Master’s of Science in Clinical Research to establish himself as an investigator in patient-oriented research in uveitis. This award will provide Dr. Tsui with the support to achieve the following goals: 1) to learn biostatistics and epidemiology, 2) to become skilled at image acquisition, processing and analysis, 3) to learn about the design and implementation of clinical trials. Dr. Tsui has assembled an outstanding multi-disciplinary team of mentors to ensure that he will achieve these goals. His mentorship team consists of Dr. Gary N. Holland (Professor of Ophthalmology and an expert in pediatric uveitis), Dr. Srinivas R. Sadda (Professor of Ophthalmology and a world-leader in ophthalmic image processing and analysis), and Dr. Deborah K. McCurdy (Professor of Pediatrics, Division of Pediatric Rheumatology and an expert in pediatric arthritis). We will pursue the following specific aims: 1) develop a standardized, reproducible technique using anterior- segment optical coherence tomography to quantify AC cells, 2) longitudinally evaluate AC flare using laser flare photometry, and 3) create a predictive risk stratification model based on objective measures of intraocular inflammation. The long-term goal is that these results would support the use of objective measures in routine clinical practice and as endpoints in clinical trials. Ultimately, earlier detection and improved monitoring of uveitis in children can prevent permanent vision loss and disability. This research will lead to the submission of an R01 grant prior to the end of the K23 award to enable Dr. Tsui to become an independent clinician-scientist.

项目概要 前葡萄膜炎是儿童最常见的眼内炎症。 比成人有慢性病程，因此需要更频繁的检查来筛查和监测 目前正在对前房（AC）炎症（细胞炎症和耀斑炎症）进行临床分级。 在裂隙灯上使用广泛接受的葡萄膜炎命名标准化 (SUN) 工作组 然而，该系统具有局限性，因为它是非连续的和半定量的。 用于评估炎症的可重复的定量技术对于儿童来说至关重要，因为 他们常常无法配合裂隙灯下的长时间检查。 此 K23 以患者为导向的指导职业发展奖提案旨在评估目标 眼内炎症措施，以改善儿童前葡萄膜炎的诊断和监测。 该奖项将颁发给葡萄膜炎专家、斯坦眼科研究所助理教授 Edmund Tsui 博士。 在加州大学洛杉矶分校，拥有受保护的研究时间和正式课程，以实现 临床研究理学硕士学位，使自己成为以患者为导向的研究的研究者 该奖项将为徐博士实现以下目标提供支持：1）学习生物统计学。 和流行病学，2）熟练掌握图像采集、处理和分析，3）了解 Tsui博士组建了一支优秀的多学科团队，负责临床试验的设计和实施。 确保他实现这些目标的导师团队由 Gary N. Holland 博士组成。 Srinivas R. Sadda 博士（眼科教授和小儿葡萄膜炎专家） 眼科和眼科图像处理和分析领域的世界领先者），以及 Deborah K. McCurdy（儿科教授，小儿风湿病科，小儿关节炎专家）。 我们将追求以下具体目标：1）使用前路技术开发标准化的、可重复的技术 分段光学相干断层扫描来量化 AC 细胞，2) 使用激光纵向评估 AC 耀斑 耀斑光度测定，3) 基于眼内客观测量创建预测风险分层模型 长期目标是这些结果将支持在常规中使用客观措施。 临床实践并作为临床试验的终点，最终是早期发现和改进监测。 儿童葡萄膜炎可以预防永久性视力丧失和残疾。这项研究将导致提交。 在 K23 奖项结束之前获得 R01 资助，使徐博士能够成为一名独立的临床医生科学家。