CHARACTERIZING AND IMPROVING HUMANIZED IMMUNE SYSTEM MOUSE MODELS (IMM-HIS)

人源化免疫系统小鼠模型 (IMM-HIS) 的表征和改进

基本信息

批准号：
10282227
负责人：
JULIE LANG
金额：
$ 204.14万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-30 至 2023-09-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10282227
关键词：
Allografting Architecture Cells Chimerism Communities Contracts Development Enzyme-Linked Immunosorbent Assay Flow Cytometry Hematopoietic stem cells Human Immune Immune system Immunization Implant Intestines Lead Liver Lung Lymphoid Cell Lymphoid Tissue Measurement Modeling Mus Neonatal Organ Population Production Testing Thymic Tissue Thymus Gland Time Training Transplantation Umbilical Cord Blood Vaccination aged allograft rejection cytokine improved member mouse model tumor growth

Allografting Architecture Cells Chimerism Communities Contracts Development Enzyme-Linked Immunosorbent Assay Flow Cytometry Hematopoietic stem cells Human Immune Immune system Immunization Implant Intestines Lead Liver Lung Lymphoid Cell Lymphoid Tissue Measurement Modeling Mus Neonatal Organ Population Production Testing Thymic Tissue Thymus Gland Time Training Transplantation Umbilical Cord Blood Vaccination aged allograft rejection cytokine improved member mouse model tumor growth

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项目摘要

This contract proposes to develop, optimize, and test the production of HIS mice using hematopoietic stem cells from cord blood, including the co-transplantation of neonatal thymic tissue. Comprehensive characterizations of the adaptive and innate human immune systems will include testing its ability to respond to a standard human vaccination and an allograft. The chosen models for optimization and improvement center on increasing populations of innate lymphoid cells which facilitate lymphoid tissue development, that in turn would lead to more robust and complete development of the human immune system.

该合同建议使用脐带血中的造血干细胞（包括新生儿胸腺组织的共移植）开发，优化和测试小鼠的产生。适应性和先天性免疫系统的全面表征将包括测试其对标准人类疫苗接种和同种异体移植的反应能力。选定的用于优化和改进的模型，促进了促进淋巴组织发展的先天淋巴样细胞种群的增加，这又会导致人类免疫系统的更强大而完整的发展。