Marijuana Harm Reduction: Innovative Strategies for Developing New Knowledge

减少大麻危害：开发新知识的创新策略

• 批准号: 10307408
• 负责人: KENT E. HUTCHISON
• 金额: $ 20.28万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10307408
• 关键词: Marijuana; Harm; Reduction; Innovative; Strategies

DESCRIPTION (provided by applicant): Over the last two years, the United States has witnessed enormous changes concerning the acceptance of marijuana. In 2015, Colorado state officials expect demand in the legal market to exceed 130 metric tons. Given these changes, the scientific literature that should inform public policy regarding harm reduction is inadequate and outdated. There are a number of critical limitations in the extant literature that need to be addressed if scientists are to have an influence on the regulation of marijuana. Scientists need to understand the effects of commonly used marijuana strains, as they are used in everyday life, as opposed to relying solely on testing the effects of government grown marijuana in controlled laboratory experiments. In addition, scientists need to conceptualize the effects of marijuana as the compound action of different cannabinoids, specifically tetrahydrocannabinol (THC) and cannabidiol (CBD). The ratio of CBD to THC may have an important impact on the effects of the marijuana, which in turn may have important implications for harm reduction. The overarching objective of the proposed research is to advance a more nuanced understanding of the potential harm associated with different strains of marijuana, using an observational design with high external validity, thereby avoiding many of the limitations of previous research. The first specifi aim will examine three strains that differ markedly on THC potency (6%, 12%, 18%) but do not differ on the potency of other major cannabinoids (< .5%) to determine whether the level of THC is associated with increased intoxication and greater harmful effects. It is hypothesized that the higher potency marijuana will be associated with greater blood levels of THC and diminished working memory and increased ratings of drug reward. The second specific aim will examine whether CBD moderates the harmful effects of THC and will identify the ratio of CBD to THC with the lowest harmful effects. To this end, 180 regular users will be assigned to one of five strains of marijuana with different ratios of CBD to THC, ranging approximately from 1:20 to 20:1. It is hypothesized that the strains with a high CBD to THC ratio will demonstrate the least amount of harm on measures of memory and drug reward. The information gained from this research will inform the public about the potential harms of different cannabinoids and strains. It may also have a translational application with respect to identifying THC levels or CBD to THC ratios that could be the focus of future regulatory actions.

描述（由申请人提供）：过去两年，美国在接受大麻方面发生了巨大变化。 2015年，科罗拉多州官员预计合法市场的需求量将超过130吨。鉴于这些变化，为减少危害公共政策提供信息的科学文献是不充分且过时的。如果科学家想要对大麻的监管产生影响，现有文献中存在许多关键局限性，需要解决这些局限性。科学家需要了解常用大麻品种的影响，因为它们在日常生活中使用，而不是仅仅依靠在受控实验室实验中测试政府种植的大麻的影响。此外，科学家需要将大麻的作用概念化为不同大麻素，特别是四氢大麻酚（THC）和大麻二酚（CBD）的复合作用。 CBD 与 THC 的比例可能对大麻的效果产生重要影响，这反过来又可能对减少危害产生重要影响。拟议研究的总体目标是使用具有高外部效度的观察设计，促进对不同大麻品种相关潜在危害的更细致的了解，从而避免先前研究的许多局限性。第一个具体目标将检查 THC 效力显着差异（6%、12%、18%）但其他主要大麻素效力没有差异（< .5%）的三种菌株，以确定 THC 水平是否相关中毒程度增加，有害影响更大。据推测，大麻的效力越高，血液中的四氢大麻酚浓度越高，工作记忆力下降，药物奖励等级越高。第二个具体目标将检查 CBD 是否可以减轻 THC 的有害影响，并确定 CBD 与 THC 的有害影响最低的比例。为此，180 名常规使用者将被分配到五种大麻中的一种，其 CBD 与 THC 的比例不同，范围约为 1:20 至 20:1。据推测，CBD 与 THC 比例较高的菌株对记忆和药物奖励的影响最小。从这项研究中获得的信息将使公众了解不同大麻素和菌株的潜在危害。它 还可能在确定 THC 水平或 CBD 与 THC 比率方面具有转化应用，这可能是未来监管行动的重点。

项目成果

Analysis of 14 endocannabinoids and endocannabinoid congeners in human plasma using column switching high-performance atmospheric pressure chemical ionization liquid chromatography-mass spectrometry.

使用柱切换高性能大气压化学电离液相色谱-质谱法分析人血浆中的 14 种内源性大麻素和内源性大麻素同系物。

• DOI: 10.1007/s00216-021-03280-0
• 发表时间: 2021
• 期刊: Analytical and bioanalytical chemistry
• 影响因子: 4.3
• 作者: Sempio,Cristina;Klawitter,Jelena;Jackson,Matthew;Freni,Francesca;Shillingburg,Ryan;Hutchison,Kent;Bidwell,LCinnamon;Christians,Uwe;Klawitter,Jost
• 通讯作者: Klawitter,Jost

Cannabinoid Exposure and Subjective Effects of THC and CBD in Edible Cannabis Products.

食用大麻产品中大麻素的暴露以及 THC 和 CBD 的主观影响。

• DOI: 10.1089/can.2022.0020
• 发表时间: 2024
• 期刊: Cannabis and cannabinoid research
• 影响因子: 3.8
• 作者: Gibson,LaurelP;Mueller,RaeghanL;Winiger,EvanA;Klawitter,Jost;Sempio,Cristina;Williams,Sarah;Bryan,AngelaD;Bidwell,LCinnamon;Hutchison,KentE
• 通讯作者: Hutchison,KentE

Associations between self-reported cannabis use frequency, potency, and cannabis/health metrics.

• DOI: 10.1016/j.drugpo.2021.103278
• 发表时间: 2021-11
• 期刊: The International journal on drug policy
• 作者: Steeger CM;Hitchcock LN;Bryan AD;Hutchison KE;Hill KG;Bidwell LC
• 通讯作者: Bidwell LC

Effects of cannabidiol in cannabis flower: Implications for harm reduction.

• DOI: 10.1111/adb.13092
• 发表时间: 2022-01
• 期刊: ADDICTION BIOLOGY
• 影响因子: 3.4
• 作者: Gibson, Laurel P.;Karoly, Hollis C.;Ellingson, Jarrod M.;Klawitter, Jost;Sempio, Cristina;Squeri, Julia E.;Bryan, Angela D.;Bidwell, L. Cinnamon;Hutchison, Kent E.
• 通讯作者: Hutchison, Kent E.