Novel Methods for Evaluating the Association of Electronic Cigarette Use with Cardiovascular Health

评估电子烟使用与心血管健康关联的新方法

基本信息

批准号：
10227805
负责人：
Andrew Stokes
金额：
$ 18.47万
依托单位：
BOSTON UNIVERSITY MEDICAL CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10227805
关键词：
Abstinence Acute Adult Aerosols Applications Grants Aromatic Polycyclic Hydrocarbons Behavior Biological Markers Biometry Blood Pressure Cardiovascular system Characteristics Cholesterol Cigar Cigarette Clinical Clinical Sciences Consequentialism Coronary heart disease Data Data Science Data Set Development Diagnosis Electronic cigarette Etiology Event Family Frequencies Funding Future Goals Health Health Professional Heart failure In Vitro Inflammation Institutes Intervention Knowledge Label Link Long-Term Effects Measures Mediating Mediation Mediator of activation protein Mentored Research Scientist Development Award Mentors Mentorship Metals Methods Modeling Myocardial Infarction National Health and Nutrition Examination Survey Nicotine Nitrosamines Outcome Oxidative Stress Patient Self-Report Pattern Policies Population Population Assessment of Tobacco and Health Population Research Probability Program Development Prospective cohort study Randomized Controlled Trials Research Research Personnel Residual state Risk Risk Factors Role Safety Sample Size Scientist Secure Series Smokeless Tobacco Statistical Methods Stroke Structural Models Testing Thrombosis Time Tobacco Tobacco use Training Training Activity Translational Research Triglycerides United States Food and Drug Administration United States National Institutes of Health Work base biomarker signature cardiovascular disorder epidemiology cardiovascular effects cardiovascular health cardiovascular injury cardiovascular risk factor career cigarette smoking cigarillos design e-cigarette aerosols early-career faculty electronic cigarette use evidence base high risk population in vivo innovation multidisciplinary non-cigarette tobacco product novel population based population health pre-clinical programs public health intervention skills tobacco products tobacco regulatory science urinary volatile organic compound

项目摘要

Project Summary This proposed 5-year study brings together Dr. Stokes’ training in population health and research on tobacco use behaviors with additional training in tobacco regulatory science, cardiovascular (CV) epidemiology, advanced biostatistics, and applied data science. To this end, Dr. Stokes has assembled a multidisciplinary team of mentors and advisors to aid his training and studies. The K01 will support a complementary set of training activities, including formal coursework, participation in the Early Career Faculty Development Program, the NIH-funded Clinical and Translational Science Institute sponsored K-to-R PRIME program, and strong mentorship from experts in relevant fields, to help him in his professional development and transition to independence. Population-based evidence on the CV effects of e-cigarette use is sparse, and the particular components of e-cigarette aerosols that may be responsible for CV harm remain poorly elucidated. The proposed research will integrate state-of-the-art causal inference methods, mediation analyses, and unsupervised data clustering approaches with the study of CV effects of e-cigarette use. The applicant will 1) examine the association of e-cigarette use and product transitions with incident CV events; 2) estimate associations of e-cigarette use with risk factors and preclinical biomarkers of CV injury, and analyze biomarkers of exposure as potential mediators; and 3) identify unique biomarker signatures of e-cigarette exposure using a data-driven clustering approach, and associate clusters with preclinical biomarkers of CV injury. With high quality population data and novel statistical methods to optimally control for cigarette smoking and other tobacco product use, the results of this project will provide timely and rigorous evidence on the CV effects of e-cigarette use. Together with evaluating the mediating role of exposure biomarkers and clustered e- cigarette use behavior patterns, the results will inform Food and Drug Administration regulatory standards for product safety and guide primary and secondary public health interventions that aim to reduce tobacco-related CV harm. The methods and findings will also inform future studies focused on other non-cigarette tobacco products, such as little cigars, cigarillos, and smokeless tobacco products. The additional training and protected time afforded by the K01 will aid Dr. Stokes in making his transition to an independent investigator capable of securing R-series NIH funding.

项目概要这项拟议的为期 5 年的研究汇集了斯托克斯博士在人口健康方面的培训和烟草研究使用行为并接受烟草监管科学、心血管（CV）流行病学、为此，斯托克斯博士汇集了先进的生物统计学和应用数据科学。 K01 将支持一套互补的导师和顾问团队来帮助他的培训和学习。培训活动，包括正式课程、参与早期职业教师发展计划、 NIH 资助的临床和转化科学研究所赞助的 K-to-R PRIME 计划，以及强大的相关领域专家的指导，帮助他的专业发展和过渡关于电子烟使用对心血管影响的基于人群的证据很少，而且具体情况还不清楚。可能导致心血管损害的电子烟气溶胶成分仍不清楚。拟议的研究将整合最先进的因果推理方法、中介分析和采用无监督数据聚类方法研究电子烟使用的心血管效应：1) 检查电子烟使用和产品转换与心血管事件的关联 2) 估计；电子烟使用与心血管损伤危险因素和临床前生物标志物的关联，并分析暴露的生物标志物作为潜在介质；3) 识别电子烟的独特生物标志物特征使用数据驱动的聚类方法进行暴露，并将聚类与 CV 的临床前生物标志物相关联凭借高质量的人口数据和新颖的统计方法来最佳地控制吸烟。和其他烟草制品的使用，该项目的结果将为简历提供及时而严格的证据电子烟使用的影响，同时评估暴露生物标志物和聚集电子烟的中介作用。香烟使用行为模式，结果将告知食品和药物管理局的监管标准产品安全并指导旨在减少烟草相关的初级和次级公共卫生干预措施这些方法和研究结果也将为未来针对其他非卷烟烟草的研究提供信息。产品，例如小雪茄、小雪茄和无烟烟草产品。 K01 提供的受保护时间将帮助 Stokes 博士过渡到独立调查员能够获得 R 系列 NIH 资助。