Ultra-Resolution Imaging on Standard Clinical CT

标准临床 CT 的超分辨率成像

基本信息

批准号：
10226095
负责人：
Lin Fu
金额：
$ 72.02万
依托单位：
GENERAL ELECTRIC GLOBAL RESEARCH CTR
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-02 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10226095
关键词：
3-Dimensional Affect Algorithms Anatomy Applications Grants Area Cadaver Caring Cells Characteristics Clinical Cochlea Cochlear Implants Dental Care Development Dose Ear Evaluation Eye Fracture Goals Gold Head Healthcare High Resolution Computed Tomography Hospitals Image Implantation procedure Incubated Institutes Investments Labyrinth Lateral Lead Limb structure Massachusetts Maxillofacial Procedures Methods Monitor Morphologic artifacts Motion Names Neck Noise Nose Operative Surgical Procedures Osteoporosis Outcome Patients Pharyngeal structure Plants Radiation Research Resolution Roentgen Rays Scanning Scheme Site Source Special Hospitals Specimen Spinal Fusion Spinal Stenosis Spottings Structure System Tail Techniques Temporal bone structure Translations Tube Vertebral column Work X-Ray Computed Tomography base bone bone imaging clinical application comparative cost cost effective deaf design detector fracture risk healing hip replacement arthroplasty image reconstruction imaging capabilities improved in vivo inner ear diseases innovation interest medical specialties microCT middle ear minimally invasive new technology osteoporosis with pathological fracture patient population reconstruction spine bone structure standard of care temporal measurement treatment response validation studies

3-Dimensional Affect Algorithms Anatomy Applications Grants Area Cadaver Caring Cells Characteristics Clinical Cochlea Cochlear Implants Dental Care Development Dose Ear Evaluation Eye Fracture Goals Gold Head Healthcare High Resolution Computed Tomography Hospitals Image Implantation procedure Incubated Institutes Investments Labyrinth Lateral Lead Limb structure Massachusetts Maxillofacial Procedures Methods Monitor Morphologic artifacts Motion Names Neck Noise Nose Operative Surgical Procedures Osteoporosis Outcome Patients Pharyngeal structure Plants Radiation Research Resolution Roentgen Rays Scanning Scheme Site Source Special Hospitals Specimen Spinal Fusion Spinal Stenosis Spottings Structure System Tail Techniques Temporal bone structure Translations Tube Vertebral column Work X-Ray Computed Tomography base bone bone imaging clinical application comparative cost cost effective deaf design detector fracture risk healing hip replacement arthroplasty image reconstruction imaging capabilities improved in vivo inner ear diseases innovation interest medical specialties microCT middle ear minimally invasive new technology osteoporosis with pathological fracture patient population reconstruction spine bone structure standard of care temporal measurement treatment response validation studies

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项目摘要

PROJECT SUMMARY/ABSTRACT Despite great strides in improving the volume coverage, temporal resolution, and dose efficiency of clinical CT scanners, the spatial resolution has plateaued since the mid-1980s. Nevertheless, there is a clear clinical need to reveal a new level of anatomic detail for CT imaging in multiple areas, including assessment of bone fractures, bone microarchitecture and fracture risk, spinal stenosis, spinal fusion healing after surgery, and cochlear im- plant placement. Various attempts have been made to improve the spatial resolution of CT, but the improvements have been incremental and there is still no practical solution that can enable in vivo ultra-resolution imaging on standard clinical CT scanners: a redesign of the CT detector array to one with finer pitched cells is very expensive for widespread application, while high-resolution extremity CT and flat-panel CT have limited bore size and suffer from inherent image quality issues, respectively. We propose a new ultra-resolution CT technique, named “Zoomed-In Partial Scan” (ZIPS), to achieve a ma- jor improvement in the spatial resolution of standard, clinical CT. The increased spatial resolution is achieved by combining an extra small focal spot with a large magnification, and with innovative scanning schemes and re- construction algorithms. The ZIPS method can be incorporated on existing standard clinical CT scanners, with- out a costly redesign of the CT detector based on smaller cells or sacrificing image quality or dose efficiency in regular scans. Compared with various specialized high-resolution research CT scanners, the proposed ZIPS method leverages the accessibility, versatility, and wide volume coverage of standard clinical CT to provide an in vivo ultra-resolution option for a wide patient population and various anatomical regions. The project combines CT systems and reconstruction expertise at GE Research Center and clinical applica- tion expertise at the Hospital for Special Surgery (HSS) and the Massachusetts Eye and Ear Institute (MEEI). The GE Research Center team will perform all technical developments of this project. The HSS team will lead an ex vivo validation study of the ZIPS CT technique applied to bone microstructure analysis, and compare results with µCT gold standard and standard clinical CT. MEEI will provide clinical expertise in the evaluation of ZIPS CT for temporal bone imaging.

项目摘要/摘要尽管在改善临床CT的体积覆盖率，暂时分辨率和剂量效率方面取得了长足的进步扫描仪，自1980年代中期以来，空间分辨率已经平稳。然而，明显的临床需要在多个区域中揭示了CT成像的新水平，包括评估骨折的评估，骨微体系结构和骨折风险，脊髓狭窄，脊柱融合愈合后以及人工耳蜗植物位置。已经尝试了改善CT的空间分辨率的各种尝试，但是改进已经进行了增量，仍然没有实用的解决方案可以使体内超分辨率成像标准成像临床CT扫描仪：将CT检测器阵列重新设计为具有较细胞的细胞非常昂贵宽度应用程序，而高分辨率的肢体CT和Flat-Panel CT的孔径有限和患者分别从继承图像质量问题中。我们提出了一种新的超分辨率CT技术，称为“放大部分扫描”（ZIPS），以实现MA- 标准临床CT的空间分辨率的JOR改进。空间分辨率提高是通过将一个额外的小焦点与大放大倍数结合在一起，并与创新的扫描方案和重新相结合施工算法。可以将ZIPS方法纳入现有的标准临床CT扫描仪，并具有 - 基于较小的细胞或牺牲图像质量或剂量效率的CT检测器的昂贵重新设计定期扫描。与各种专门的高分辨率研究CT扫描仪相比，提议的拉链方法利用标准临床CT的可访问性，多功能性和广泛的覆盖范围来提供用于广泛的患者人群和各种解剖区域的体内超分辨率选择。该项目结合了GE研究中心和临床应用的CT系统和重建专业知识特殊外科医院（HSS）和马萨诸塞州眼科研究所（MEEI）的专业知识。 GE研究中心团队将执行该项目的所有技术发展。 HSS团队将领导用于骨微结构分析的ZIPS CT技术的离体验证研究，并比较结果具有µCT金标准和标准临床CT。 MEEI将在评估拉链方面提供临床专业知识 CT用于临时骨成像。