Repetitive Thinking and Emotional Health in Adults with ASD

自闭症谱系障碍成人的重复思维和情绪健康

• 批准号: 10224641
• 负责人: Katherine O Gotham
• 金额: $ 40.82万
• 依托单位: ROWAN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10224641
• 关键词: Adult; Affective; Anxiety; Caregiver Burden; Characteristics; Clinical; Code; Cognitive; Complex; Data; Data Collection; Depressed mood; Development; Diagnosis; Diagnostic; Dimensions; Emotional; Equation; Face; Failure; General Population; Goals; Health; Health behavior; Hobbies; Intervention; Language; Linear Regressions; Link; Longevity; Matched Group; Measurement; Measures; Mediating; Mental Depression; Methods; Modeling; Mydriasis; Obsession; Occupations; Outcome; Participant; Patient Self-Report; Pattern; Personal Satisfaction; Physiological; Play; Population; Problem Solving; Process; Psychometrics; Pupil; Quality of life; Reflex action; Research; Response to stimulus physiology; Role; Sampling; Services; Shapes; Special Population; Stimulus; Structure; Surveys; Symptoms; Testing; Thinking; Underserved Population; Work; adult with autism spectrum disorder; autism spectrum disorder; base; behavioral health; clinically significant; cohort; comorbidity; depressive symptoms; emotional stimulus; experience; improved; indexing; instrument; interest; neural correlate; neural patterning; neuromechanism; novel; novel marker; physical conditioning; relating to nervous system; repetitive behavior; response; skills; social; social deficits; therapy design; therapy development

Project Summary/Abstract Adults with autism spectrum disorder (ASD) often have poor outcomes across a range of domains, particularly emotional health. Rumination, or repetitive negative thinking, is a cognitive characteristic of ASD that also appears to contribute to depression and anxiety. Rumination is linked to both poor emotional and physical health in the general population. However, as perseveration is a core feature of autism, repetitive thinking (RepT) within ASD appears to be a broader construct than general rumination. Better understanding of the phenomenon, mechanisms, and health states associated with RepT in autism could determine novel, specific targets to guide development of health interventions for adults with ASD. Our proposal seeks to characterize repetitive thinking within ASD and inform its psychometric measurement in this population (Aim 1); explore neural correlates of sustained cognitive-affective processing in adults with ASD using pupil methods, with comparisons to typically developing depressed adults (TD-dep) (Aim 2); and investigate relations between diverse forms of RepT and health and behavior in adults with ASD (Aim 3). This work is intended to shape precision hypotheses as to which specific RepT processes most impact which adverse health outcomes in this special population. Aim 1 takes a mixed-method approach, including: (1) structural analyses of survey data on various constructs related to RepT (e.g., rumination, worry, obsessive thoughts, circumscribed interests) to identify common patterns of repetitive thinking (e.g., by valence, function, intrusiveness) in a large sample of verbally-fluent adults with ASD, n=760 online + n=72 in lab; and (2) lab- based inductions of RepT, with pre-/post language samples coded for RepT features. Findings will be synthesized to inform understanding of the phenomenon and measurement of RepT in ASD. In Aim 2, patterns of pupil-indexed neural reactivity will be compared across diagnostic cohorts (ASD and TD-dep) and stimuli types (social, non-social, emotional, non-emotional), and assessed for relation to RepT features and other moderators. This is intended to illuminate patterns of sustained cognitive-affective processing in ASD, and thus refine future research into mechanistic “points of entry” for treatment development. Aim 3 proposes to analyze both existing and novel markers of diverse forms of RepT for differential association with health and functioning in adults with ASD. A model will be tested in which negative RepT predicts poor emotional and physical health, whereas positive/neutral RepT predicts social deficits. This proposal applies an expert team and multi-method approach to the goal of identifying potential targets for intervention on emotional health problems, which are prevalent and largely untreated in adults with ASD. If successful, this also will structure empirical data collection on RepT, advance understanding of its mechanisms via a convergent physiological marker (sustained pupil responsivity), and help extend repetitive behavior research to internal thinking processes.

项目概要/摘要 患有自闭症谱系障碍 (ASD) 的成年人通常在一系列领域都表现不佳，特别是 情绪健康，或重复的消极思考，是自闭症谱系障碍的一个认知特征。 沉思似乎会导致抑郁和焦虑，与情绪和身体状况不佳有关。 然而，由于坚持不懈是自闭症的核心特征，重复性思维。 自闭症谱系障碍（ASD）中的（RepT）似乎是一个比一般反思更广泛的概念。 与自闭症 RepT 相关的现象、机制和健康状况可以确定新的、特定的 指导制定针对自闭症谱系障碍成人的健康干预措施的目标。 我们的建议旨在描述 ASD 中重复思维的特征，并为其心理测量提供信息 该人群（目标 1）；探索自闭症谱系障碍成人持续认知情感处理的神经相关性 使用学生方法，与典型的抑郁成年人进行比较（TD-dep）（目标 2）； 研究不同形式的 RepT 与 ASD 成人的健康和行为之间的关系（目标 3）。 工作的目的是形成精确的假设，以确定哪些特定的 RepT 流程对哪些流程影响最大 目标 1 采用混合方法，包括：(1) 对与 RepT 相关的各种结构的调查数据进行结构分析（例如，沉思、担忧、强迫） 想法、有限的兴趣）来识别重复思维的常见模式（例如，通过价、功能、 侵入性）在语言流利的 ASD 成年人的大样本中，n = 760 在线 + n = 72 在实验室和（2）实验室 - 基于 RepT 的归纳，以及为 RepT 特征编码的前/后语言样本。 旨在帮助理解自闭症谱系障碍 (ASD) 中 RepT 的现象和测量。目标 2：模式。 将在诊断队列（ASD 和 TD-dep）和刺激之间比较瞳孔指数神经反应性 类型（社交、非社交、情感、非情感），并评估与 RepT 特征和其他特征的关系 这是为了阐明自闭症谱系障碍中持续认知情感处理的模式，从而阐明自闭症谱系障碍中持续认知情感处理的模式。 将未来研究细化为治疗开发的机械“切入点”。目标 3 建议进行分析。 不同形式 RepT 的现有标记和新标记与健康和功能的差异关联 将在患有 ASD 的成人中测试一个模型，其中阴性 RepT 预测情绪和身体健康状况不佳， 而正/中性 RepT 则预测社会赤字。该提案采用了专家团队和多种方法。 确定情绪健康问题干预潜在目标的方法，这些目标是 如果成功的话，这也将构建经验数据。 RepT 上的集合，通过聚合生理标记加深对其机制的理解 （持续的学生反应能力），并有助于将重复行为研究扩展到内部思维过程。