Forward viewing catheter-delivered microbubble enhanced sonothrombolysis (FV-CAMUS)

前视导管微泡增强超声溶栓 (FV-CAMUS)

基本信息

批准号：
10219344
负责人：
Xiaoning Jiang
金额：
$ 52.24万
依托单位：
NORTH CAROLINA STATE UNIVERSITY RALEIGH
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-15 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10219344
关键词：
Acoustics Acute Affect Alteplase American Animals Basic Science Blood coagulation Caliber Catheters Cessation of life Clinical Coagulation Process Contrast Media Cytolysis Deep Vein Thrombosis Development Devices Disease Distal Drug Delivery Systems Embolism Endothelium Failure Family suidae Femoral vein Fibrinolysis Fibrinolytic Agents Focused Ultrasound Frequencies Functional disorder Goals Heating Hemorrhage Hour In Vitro Injections Injury Intravenous Leg Letters Lung Lytic Malignant Neoplasms Measures Mechanics Mediating Microbubbles Modeling Monitor Morbidity - disease rate Output Pain Particle Size Pathologic Patients Penetration Performance Peripheral Pharmaceutical Preparations Pharmacology Postphlebitic Syndrome Procedures Prognosis Pulmonary Embolism Quality of life Recurrence Research Residual state Risk Safety Side Source Survivors System Techniques Technology Testing Thrombectomy Thrombosis Thrombus Time Tissues Transducers Translation Process Tube Ulcer Ultrasonic Transducer Ultrasonography Validation Vascular Diseases Veins Venous Work base bone clinical translation clinically significant contrast enhanced deep vein design effective therapy improved in vivo in vivo evaluation innovation innovative technologies interest mortality nanoDroplet new technology novel novel strategies patient population phase change prototype thrombolysis tool

项目摘要

Forward viewing catheter-delivered microbubble enhanced sonothrombolysis (FV-CAMUS) Deep vein thrombosis (DVT) induced pulmonary embolism (PE) causes more than 0.1 million deaths annually in the US alone. Recent innovative treatment techniques for thrombolysis, such as pharmacological dissolution or fibrinolysis and mechanical fragmentation, have showed progressive results, yet still suffer from severe limitations such as low thrombolysis efficiency and long treatment times, frequent bleeding complications, high failure rate, vein injury associated with severe regional dysfunction, recurrence, and the relatively large particle size of residual clot debris which can result in distal embolism. This has led to great interest in sonothrombolysis, the use of focused ultrasound to disrupt clots, yet current commercial sonothrombolysis systems (e.g. EKOS) are still limited by long treatment times and peripheral tissue damage due to heating and excessive acoustic exposure. More recently, our group and others have demonstrated several advances which promise to improve the performance (significantly reduced treatment time) and safety of thrombolysis using a microbubble-mediated forward-looking dual frequency catheter based technology. We hypothesize that the development of a new approach for catheter sonothrombolysis combining multi-frequency tools as well as cavitation-enhancing agents can substantially improve the efficacy, safety, and impact of this approach. In this project, we develop innovative technologies from our collaborative group, each of which has shown notable advantages over current technology, and we hypothesize that together they can overcome existing challenges in the aforementioned acute embolism treatments. Specifically, a 4-French catheter will be integrated with dual acoustic sources - a small aperture dual frequency forward-looking ultrasound transducer, combined with a micro-tube for delivery of microbubbles and lytic agent (tissue-type plasminogen activator or t-PA), to achieve Forward Viewing CAtheter- delivered MicrobUbble enhanced Sonothrombolysis (FV-CAMUS). The FV-CAMUS catheter will be designed, prototyped and characterized, followed by in-vitro, ex-vivo and in-vivo thrombolysis tests in large animals. The proposed FV-CAMUS technology will provide a new tool enabling accurate, fast, and safe thrombus treatment.

前视导管微泡增强超声溶栓 (FV-CAMUS) 深静脉血栓 (DVT) 引起的肺栓塞 (PE) 每年导致超过 10 万人死亡仅在美国。溶栓治疗的最新创新治疗技术，例如药物溶解或纤维蛋白溶解和机械碎裂，已显示出渐进的结果，但仍然遭受严重的溶栓效率低、治疗时间长、出血并发症多、治疗费用高等局限性失败率、静脉损伤伴有严重的区域功能障碍、复发以及相对较大的颗粒残余血栓碎片的大小可能导致远端栓塞。这引起了人们对超声溶栓的极大兴趣，使用聚焦超声来破坏血栓，但目前的商业超声溶栓系统（例如 EKOS）仍然受到治疗时间长以及由于加热和过度声波导致的周围组织损伤的限制接触。最近，我们的团队和其他人展示了几项进展，有望改善使用微泡介导的溶栓的性能（显着减少治疗时间）和安全性基于前瞻性双频导管的技术。我们假设新的开发结合多频工具和空化增强剂的导管超声溶栓方法可以大大提高这种方法的有效性、安全性和影响。在这个项目中，我们开发创新我们合作小组的技术，每一项都比当前的技术显示出显着的优势技术，我们假设它们可以共同克服上述领域的现有挑战急性栓塞治疗。具体来说，4-French 导管将与双声源集成 - 小孔径双频前视超声换能器，与微管相结合，用于输送微泡和溶解剂（组织型纤溶酶原激活剂或t-PA），以实现前视导管- 交付微泡增强超声溶栓 (FV-CAMUS)。 FV-CAMUS 导管将被设计，进行原型设计和表征，然后在大型动物中进行体外、离体和体内溶栓试验。这拟议的 FV-CAMUS 技术将提供一种新的工具，实现准确、快速和安全的血栓治疗。

项目成果

期刊论文数量（14）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（1）

Recent Advances in Transducers for Intravascular Ultrasound (IVUS) Imaging.

DOI：
10.3390/s21103540
发表时间：
2021-05-19
期刊：
Sensors (Basel, Switzerland)
影响因子：
0
作者：
Peng C;Wu H;Kim S;Dai X;Jiang X
通讯作者：
Jiang X

Nanodroplet-mediated catheter-directed sonothrombolysis of retracted blood clots.

DOI：
10.1038/s41378-020-00228-9
发表时间：
2021
期刊：
Microsystems & nanoengineering
影响因子：
7.9
作者：
Goel L;Wu H;Zhang B;Kim J;Dayton PA;Xu Z;Jiang X
通讯作者：
Jiang X

Ultrasound-Guided Intravascular Sonothrombolysis With a Dual Mode Ultrasound Catheter: In Vitro Study.

DOI：
10.1109/tuffc.2022.3153929
发表时间：
2022-06
期刊：
IEEE transactions on ultrasonics, ferroelectrics, and frequency control
影响因子：
0
作者：
通讯作者：

Safety Evaluation of a Forward-Viewing Intravascular Transducer for Sonothrombolysis: An in Vitro and ex Vivo Study.

DOI：
10.1016/j.ultrasmedbio.2021.07.018
发表时间：
2021-11
期刊：
Ultrasound in medicine & biology
影响因子：
2.9
作者：
Goel L;Wu H;Zhang B;Kim J;Dayton PA;Xu Z;Jiang X
通讯作者：
Jiang X

Miniaturized Stacked Transducer for Intravascular Sonothrombolysis With Internal-Illumination Photoacoustic Imaging Guidance and Clot Characterization.

用于血管内超声溶栓的微型堆叠换能器，具有内部照明光声成像引导和凝块表征。

DOI：
10.1109/tbme.2023.3240725
发表时间：
2023
期刊：
IEEE transactions on bio-medical engineering
影响因子：
0
作者：
Wu,Huaiyu;Tang,Yuqi;Zhang,Bohua;Klippel,Paul;Jing,Yun;Yao,Junjie;Jiang,Xiaoning
通讯作者：
Jiang,Xiaoning