Forward viewing catheter-delivered microbubble enhanced sonothrombolysis (FV-CAMUS)

前视导管微泡增强超声溶栓 (FV-CAMUS)

基本信息

批准号：
10219344
负责人：
Xiaoning Jiang
金额：
$ 52.24万
依托单位：
NORTH CAROLINA STATE UNIVERSITY RALEIGH
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-15 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10219344
关键词：
Acoustics Acute Affect Alteplase American Animals Basic Science Blood coagulation Caliber Catheters Cessation of life Clinical Coagulation Process Contrast Media Cytolysis Deep Vein Thrombosis Development Devices Disease Distal Drug Delivery Systems Embolism Endothelium Failure Family suidae Femoral vein Fibrinolysis Fibrinolytic Agents Focused Ultrasound Frequencies Functional disorder Goals Heating Hemorrhage Hour In Vitro Injections Injury Intravenous Leg Letters Lung Lytic Malignant Neoplasms Measures Mechanics Mediating Microbubbles Modeling Monitor Morbidity - disease rate Output Pain Particle Size Pathologic Patients Penetration Performance Peripheral Pharmaceutical Preparations Pharmacology Postphlebitic Syndrome Procedures Prognosis Pulmonary Embolism Quality of life Recurrence Research Residual state Risk Safety Side Source Survivors System Techniques Technology Testing Thrombectomy Thrombosis Thrombus Time Tissues Transducers Translation Process Tube Ulcer Ultrasonic Transducer Ultrasonography Validation Vascular Diseases Veins Venous Work base bone clinical translation clinically significant contrast enhanced deep vein design effective therapy improved in vivo in vivo evaluation innovation innovative technologies interest mortality nanoDroplet new technology novel novel strategies patient population phase change prototype thrombolysis tool

项目摘要

Forward viewing catheter-delivered microbubble enhanced sonothrombolysis (FV-CAMUS) Deep vein thrombosis (DVT) induced pulmonary embolism (PE) causes more than 0.1 million deaths annually in the US alone. Recent innovative treatment techniques for thrombolysis, such as pharmacological dissolution or fibrinolysis and mechanical fragmentation, have showed progressive results, yet still suffer from severe limitations such as low thrombolysis efficiency and long treatment times, frequent bleeding complications, high failure rate, vein injury associated with severe regional dysfunction, recurrence, and the relatively large particle size of residual clot debris which can result in distal embolism. This has led to great interest in sonothrombolysis, the use of focused ultrasound to disrupt clots, yet current commercial sonothrombolysis systems (e.g. EKOS) are still limited by long treatment times and peripheral tissue damage due to heating and excessive acoustic exposure. More recently, our group and others have demonstrated several advances which promise to improve the performance (significantly reduced treatment time) and safety of thrombolysis using a microbubble-mediated forward-looking dual frequency catheter based technology. We hypothesize that the development of a new approach for catheter sonothrombolysis combining multi-frequency tools as well as cavitation-enhancing agents can substantially improve the efficacy, safety, and impact of this approach. In this project, we develop innovative technologies from our collaborative group, each of which has shown notable advantages over current technology, and we hypothesize that together they can overcome existing challenges in the aforementioned acute embolism treatments. Specifically, a 4-French catheter will be integrated with dual acoustic sources - a small aperture dual frequency forward-looking ultrasound transducer, combined with a micro-tube for delivery of microbubbles and lytic agent (tissue-type plasminogen activator or t-PA), to achieve Forward Viewing CAtheter- delivered MicrobUbble enhanced Sonothrombolysis (FV-CAMUS). The FV-CAMUS catheter will be designed, prototyped and characterized, followed by in-vitro, ex-vivo and in-vivo thrombolysis tests in large animals. The proposed FV-CAMUS technology will provide a new tool enabling accurate, fast, and safe thrombus treatment.

向前查看导管传递的微泡增强的Sonothrombolysy（FV-Camus）深静脉血栓形成（DVT）诱导肺栓塞（PE）每年造成超过10万人死亡一个人在美国。最近针对溶栓的创新治疗技术，例如药理溶解或纤维蛋白溶解和机械碎片化，已经显示出渐进效果，但仍然患有严重诸如低溶栓效率和较长治疗时间，频繁出血并发症等局限性，高故障率，与严重区域功能障碍相关的静脉损伤，复发和相对较大的粒子残留的凝块碎片的大小，可能导致远端栓塞。这引起了人们对Sonothrombolysy的极大兴趣，使用集中的超声来破坏凝块，但目前的商业Sonothrombolsysy Systems（例如Ekos）由于加热和声音过多而导致的长时间治疗时间和周围组织损伤的限制接触。最近，我们的小组和其他人展示了一些进步，有望改善使用微气泡介导的性能（显着缩短治疗时间）和溶栓的安全前瞻性双重导管基于基于双重频率导管的技术。我们假设新的发展组合多频工具和增强剂的导管Sonothrombolysy方法可以大大提高这种方法的功效，安全性和影响。在这个项目中，我们发展创新我们的协作小组的技术，每个技术都表现出比当前的显着优势技术，我们假设他们可以共同克服上述的现有挑战急性栓塞治疗。具体而言，4-法国导管将与双声源集成 - A 小光圈双频率向前看起来超声传感器，并结合微管递送微泡和裂解剂（组织型纤溶酶原激活剂或T-PA），以实现向前查看导管传递的微泡增强的Sonothrombolysy（FV-Camus）。 FV-Camus导管将设计，在大型动物中进行了原型和特征，其次是体外，体内和体内溶栓测试。这拟议的FV-Camus技术将提供一种新的工具，以实现准确，快速和安全的血栓处理。

项目成果

期刊论文数量（14）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（1）

Recent Advances in Transducers for Intravascular Ultrasound (IVUS) Imaging.

DOI：
10.3390/s21103540
发表时间：
2021-05-19
期刊：
Sensors (Basel, Switzerland)
影响因子：
0
作者：
Peng C;Wu H;Kim S;Dai X;Jiang X
通讯作者：
Jiang X

Nanodroplet-mediated catheter-directed sonothrombolysis of retracted blood clots.

DOI：
10.1038/s41378-020-00228-9
发表时间：
2021
期刊：
Microsystems & nanoengineering
影响因子：
7.9
作者：
Goel L;Wu H;Zhang B;Kim J;Dayton PA;Xu Z;Jiang X
通讯作者：
Jiang X

Dual-Frequency Intravascular Sonothrombolysis: An In Vitro Study.

DOI：
10.1109/tuffc.2021.3103409
发表时间：
2021-12
期刊：
IEEE transactions on ultrasonics, ferroelectrics, and frequency control
影响因子：
0
作者：
Wu H;Goel LD;Kim H;Zhang B;Kim J;Dayton PA;Xu Z;Jiang X
通讯作者：
Jiang X

Miniaturized Stacked Transducer for Intravascular Sonothrombolysis With Internal-Illumination Photoacoustic Imaging Guidance and Clot Characterization.

用于血管内超声溶栓的微型堆叠换能器，具有内部照明光声成像引导和凝块表征。

DOI：
10.1109/tbme.2023.3240725
发表时间：
2023
期刊：
IEEE transactions on bio-medical engineering
影响因子：
0
作者：
Wu,Huaiyu;Tang,Yuqi;Zhang,Bohua;Klippel,Paul;Jing,Yun;Yao,Junjie;Jiang,Xiaoning
通讯作者：
Jiang,Xiaoning

Safety Evaluation of a Forward-Viewing Intravascular Transducer for Sonothrombolysis: An in Vitro and ex Vivo Study.