HIV Virology Core

HIV病毒学核心

• 批准号: 10219094
• 负责人: Alan N. Engelman
• 金额: $ 30.2万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-27 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10219094
• 关键词: Biochemical; Biological Assay; Capsid; Cells; Collaborations; Complement; Complex; HIV; HIV Infections; HIV-1; Image; Proteins; Resources; Structural Biologist; Structure; Testing; Validation; Virus; design; experimental study; genetic manipulation; novel; protein complex; virology; Biochemical; Biological Assay; Capsid; Cells; Collaborations; Complement; Complex; HIV; HIV Infections; HIV-1; Image; Proteins; Resources; Structural Biologist; Structure; Testing; Validation; Virus; design; experimental study; genetic manipulation; novel; protein complex; virology

HIV Virology Core Abstract The HIV Virology Core (HVC) will provide virological support for structural and biochemical studies that require functional validation. This will be accomplished through the utilization of established assays of HIV infection, replication, virus and host cell genetic manipulations, imaging, as well as biochemical assays of preintegration complex (PIC) and capsid function. The Core will validate novel capsid-interacting proteins identified in the Interactions Core and will be fully involved in several PCHPI projects, especially Projects 1-5.

HIV病毒学核心摘要 HIV病毒学核心（HVC）将为结构和生化研究提供病毒学支持， 需要功能验证。这将通过利用既定的艾滋病毒测定法实现 感染，复制，病毒和宿主细胞遗传操作，成像以及生化测定 预一体化复合物（PIC）和衣壳功能。核心将验证新型的衣壳相互作用蛋白 在互动核心中确定，将完全参与多个PCHPI项目，尤其是项目1-5。