Predoctoral Training at the Chemistry-Biology Interface

化学-生物学界面的博士前培训

• 批准号: 10202660
• 负责人: Ronen Marmorstein
• 金额: $ 29.26万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10202660
• 关键词: Biology; Chemistry; Training; pre-doctoral; Biology; Chemistry; Training; pre-doctoral

The goal of the CBI Training Program is to provide students with the intellectual and technical skills that are necessary to solve important and complex biological problems that can be most effectively addressed by studies at the chemistry-biology interface. We are focusing on the mechanistic chemistry of biomolecules that have implications for impacting human health and treatment of disease. This is a theme that is of interest to a significant population of students on campus and serves as an excellent system for the application of tools at the chemistry-biology interface to solve important biological problems. The program creates a group of chemists and biologists who can speak the same language and thereby function effectively in multidisciplinary teams. The Program involves 34 participating faculty from two separate Schools within the University of Pennsylvania, The Perelman School of Medicine (SOM) and The School of Arts and Sciences (SAS). Participating students come primarily from two graduate groups that span institution and school boundaries, the Graduate Group in Chemistry (CHEM, in SAS) and the Graduate Group in Biochemistry and Molecular Biophysics (BMB, in SOM). To ensure that students carry out research within the scope of the training program, students are selected for the program after they have chosen a thesis laboratory and project and generally in their second year. To ensure chemistry-biology interface training and cross-fertilization between the chemistry and biology students that participate in the program, students participate in the following activities: (1) research at the chemistry-biology interface, (2) didactic course-work dealing with the chemistry and biology of proteins, nucleic acids and small biomolecules, including a literature-based component, (3) an annual student-run Chemical Biophysics mini-symposia series, (4) twice monthly student luncheons, (5) an annual Chemistry-Biology Interface retreat, (6) an annual mid-Atlantic Frontiers at the Chemistry-Biology Interface Symposium, and (7) a structured career development plan. The program also has effective mechanisms in place for the recruitment and retention of underrepresented minorities as well as the disadvantaged and disabled, and for student instruction in the responsible conduct of research. We request funds for a steady state predoctoral training group of ~ 40 students, including 8 who are funded during years 2 and 3. Oversite of the Training Program is by the PI, Ronen Marmorstein and Co-PI, E. James Petersson, with input from CHEM (SAS) and BMB (SOM) External Advisory Committees and Internal CBI Training Committee, comprised of roughly equal faculty representation from the two participating schools and trainee representatives, which meets every 6 months. The CBI Training Committee votes on the selection of students for funded training slot positions, ensuring equitable distribution of students, encouraging applications from underrepresented minorities, the disadvantaged and disabled and administering other functions of the program.

CBI培训计划的目标是为学生提供智力和技术技能 解决重要且复杂的生物学问题所必需的，可以最有效地解决 化学生物学界面的研究。我们关注的是生物分子的机械化学反应 对影响人类健康和疾病的治疗有影响。这是一个感兴趣的主题 校园中的大量学生人口是应用工具的绝佳系统 化学生物学界面解决了重要的生物学问题。该程序创建了一组 化学家和生物学家可以说相同的语言，从而有效地在多学科中发挥作用 团队。该计划涉及来自大学内两所独立学校的34名参与教师 宾夕法尼亚州，佩雷曼医学院（SOM）和艺术与科学学院（SAS）。 参加的学生主要来自两个跨越机构和学校界限的研究生群体， 化学研究生组（Chem，SAS）和生物化学和分子研究生组 生物物理学（BMB，SOM）。确保学生在培训范围内进行研究 计划，学生选择了论文实验室和项目后，将选择该计划 通常在第二年。确保化学生物学界面训练和交叉施用 参加该计划的化学和生物学学生，学生参与以下 活动：（1）化学生物学界面的研究，（2）处理化学的教学课程 蛋白质，核酸和小生物分子的生物学，包括基于文献的成分，（3） 年度学生经营的化学化学生物物理学迷你符号系列，（4）每月两次学生午餐，（5） 年度化学生物学界面撤退，（6）化学生物学的年度中大西洋前沿 界面研讨会和（7）结构化的职业发展计划。该计划也有效 招募和保留人数不足的少数民族以及 不利和残疾，以及负责任的研究的学生指导。我们要求 稳态培训小组的资金约40名学生，其中包括8年级资助的8名学生 3。 CHEM（SAS）和BMB（SOM）外部咨询委员会和CBI培训委员会的投入， 由两所参与学校和学员的大致平等教师代表组成 代表每6个月开会一次。 CBI培训委员会对学生的选择进行投票 用于资助的培训老虎机职位，确保学生的公平分配，鼓励申请 代表性不足的少数民族，处于弱势和残疾的少数群体，并管理其他职能 程序。