Behavioral and Neural Correlates of Social Function in Alcohol Use Disorders

酒精使用障碍中社会功能的行为和神经相关性

基本信息

批准号：
10190735
负责人：
ANDREW S KAYSER
金额：
$ 45.6万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-15 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10190735
关键词：
Alcoholics Anonymous Alcoholism Anterior Behavior Behavioral Behavioral Mechanisms Biological Assay Biological Markers Brain Brain region Characteristics Clinical Treatment Cognitive Competence Complication Computer Models Conflict (Psychology)DSM-V Data Deception Development Diagnostic Economics Foundations Functional Magnetic Resonance Imaging Goals Human Impairment Incentives Individual Insula of Reil Interpersonal Relations Link Measures Modeling Nature Nurses Occupations Patients Perception Questionnaires Recording of previous events Resources Rewards Schizotypal Personality Disorder Social Behavior Social Environment Social Functioning Social Perception Substance Use Disorder Therapeutic Translating Variant Ventral Striatum Work addiction affective neuroscience alcohol use disorder base cognitive neuroscience experimental study neural circuit neural correlate neuroeconomics neuroimaging neuromechanism psychologic relating to nervous system research clinical testing social social cognition social deficits social neuroscience theories trait

Alcoholics Anonymous Alcoholism Anterior Behavior Behavioral Behavioral Mechanisms Biological Assay Biological Markers Brain Brain region Characteristics Clinical Treatment Cognitive Competence Complication Computer Models Conflict (Psychology)DSM-V Data Deception Development Diagnostic Economics Foundations Functional Magnetic Resonance Imaging Goals Human Impairment Incentives Individual Insula of Reil Interpersonal Relations Link Measures Modeling Nature Nurses Occupations Patients Perception Questionnaires Recording of previous events Resources Rewards Schizotypal Personality Disorder Social Behavior Social Environment Social Functioning Social Perception Substance Use Disorder Therapeutic Translating Variant Ventral Striatum Work addiction affective neuroscience alcohol use disorder base cognitive neuroscience experimental study neural circuit neural correlate neuroeconomics neuroimaging neuromechanism psychologic relating to nervous system research clinical testing social social cognition social deficits social neuroscience theories trait

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项目摘要

Project Summary Despite the widespread nature of social deficits in patients with alcohol use disorders (AUDs) and the foundational importance of adequate social function for therapies (which often directly depend upon group and other interpersonal interactions), the behavioral and neural basis of social impairments in AUDs remains understudied. A significant challenge for understanding such impairments is to link high-level theories of social behavior and cognition with the computations performed by brain circuits. Specifically, how does the brain translate social perception into social valuation, and how does such valuation influence social actions? We propose to leverage recent developments in economic theory and cognitive neuroscience to bridge this divide using a computational, model-based approach. In this proposal, we hypothesize that social impairments in subjects with alcohol use disorders are manifest in the perception of potential social partners and the value consequently assigned to them, impacting the actions that result. By evaluating well-established economic games, we will quantify how subjects with AUDs divide rewards between themselves and anonymous partners in different social contexts. We will manipulate both incentives related to how subjects divide monetary resources between themselves and various social partners, as well as the characteristics of the partners themselves by employing validated quantitative measures of social perception. To unravel the neural mechanisms supporting the above choices, we will use functional MRI to assess brain regions whose activity we hypothesize will vary parametrically with monetary decisions. We thus seek to broaden our understanding of the computations and circuits underlying social behavior. Moreover, we believe that a model-based understanding of these behaviors and neural circuits may someday guide more robust and quantitative assessments of social function in patients with alcohol use disorders, with possible implications for both clinical evaluation and treatment.

项目摘要尽管酒精使用障碍患者（AUD）和适当的社会功能对疗法的基本重要性（通常直接取决于群体和其他人际交往），AUD的社会障碍的行为和神经基础仍然存在研究了。理解这种障碍的一个重大挑战是将高级社会理论联系起来通过大脑回路执行的计算的行为和认知。具体来说，大脑如何将社会看法转化为社会估值，这种估值如何影响社会行为？我们建议利用经济理论和认知神经科学的最新发展来弥合这种鸿沟使用基于计算的基于模型的方法。在这项提议中，我们假设患有饮酒障碍的受试者的社会障碍在对潜在的社会伴侣的看法以及因此分配给他们的价值，影响了行动结果。通过评估良好的经济游戏，我们将量化AUDS主题如何分配奖励在不同社会背景下的匿名伙伴之间。我们将操纵这两个激励措施与主体如何在自己和各种社会伙伴之间分配货币资源以及伴侣本身的特征通过采用验证的社会感知定量衡量标准。到阐明支持上述选择的神经机制，我们将使用功能性MRI评估大脑区域我们假设其活动的活动将随着货币决策而变化。因此，我们寻求扩大对社会行为潜在的计算和电路的理解。此外，我们认为对这些行为和神经回路的基于模型的理解可能有一天指导对酒精使用障碍患者的社交功能的更稳健和定量评估，对临床评估和治疗的可能影响。