Antimicrobial Resistance and Therapeutic Discovery Training Program

抗菌素耐药性和治疗发现培训计划

• 批准号: 10186684
• 负责人: William Maurice Shafer
• 金额: $ 24.76万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10186684
• 关键词: Antimicrobial Resistance; Therapeutic; Training Programs

The challenge of drug-resistant microbes requires that a new generation of basic scientists be broadly trained and educated in a triad of equally important sub-disciplines of anti-infective research: i.) mechanisms of antimicrobial resistance (AMR); ii.) antimicrobial discovery and development; and iii.) vaccinology to prevent or treat infections for which antimicrobial therapies are absent or becoming ineffectual due to AMR. The continued success of the Antimicrobial Resistance and Therapeutic Discovery Training Program (ARTDTP) of Emory University will help to ensure that a cadre of investigators will be available in the future to combat the global health problem of AMR. This need for future scientists in anti-infective research is an international priority given the reduced number of new, effective antimicrobials (antibiotics and antivirals) that have entered clinical practice in the past two decades and the difficulty often faced by physicians in treating certain infections because of AMR or the lack of effective therapeutics. Thus, the objective of the competitive renewal of ARTDTP is to provide high quality training to a select group of highly motivated graduate students for careers as independent investigators. Towards that end, ARTDTP will select five Ph.D. candidates yearly from four graduate programs within the Graduate Division of Biological and Biomedical Sciences and the Department of Chemistry for a two-year period of training in the areas of AMR and therapeutic discovery through chemical or immunologic-based strategies. ARTDTP faculty members who will serve as the pool of preceptors for trainees are highly collaborative and span the university with academic appointments in basic science and clinical departments of the School of Medicine and Emory College of Arts and Sciences. Educational training will consist of a course of study and programmatic events in sub-disciplines that emphasize research and education in AMR and drug discovery or vaccine development. ARTDTP will be governed by an Executive Committee and evaluated bi-yearly by an external Advisory Committee and by trainees after completion of their two-year program of training. Recruitment of under-represented minority students (URMS) from local and national colleges and universities will be a priority for ARTDTP and specific initiatives coupled with university-based programs will be employed to maximally train URMS. In addition to training in the sub-disciplines of anti- infective research ARTDTP trainees will receive education in the essential concepts of rigor, reproducibility and ethics that are needed for careers in the biological and biomedical fields. Upon completion of training and receipt of the Ph.D. degree, ARTDTP trainees will be ready to assume post-doctoral positions in academia, government or industry that continue their interests developed through the training experience provided by our T32 pre-doctoral program.

耐药微生物的挑战要求对新一代基础科学家进行广泛培训 并接受了反感染研究同样重要的子学科的三合会的教育：i。）机制 抗菌耐药性（AMR）； ii。）抗菌发现和发育；和iii。）预防或 治疗因AMR而缺乏抗菌疗法或无效的感染。继续 Emory的抗菌素抵抗和治疗发现培训计划（ARTDTP）的成功 大学将有助于确保将来有一批调查人员来与全球作战 AMR的健康问题。对未来科学家在反感染研究中的需求是国际优先事项 进入临床实践的新的有效抗生素（抗生素和抗病毒药）数量减少 在过去的二十年中，由于AMR，医生经常面临某些感染的困难 或缺乏有效的治疗剂。因此，ARTDTP竞争更新的目的是提供高 为一组精选积极进取的研究生作为独立调查员的职业生涯的质量培训。 为此，ARTDP将选择五个博士学位。每年来自四个研究生课程的候选人 生物学和生物医学科学和化学系研究生级两年 通过化学或基于免疫学的AMR和治疗发现领域的培训 策略。 ARTDTP的教职员工将充当学员的受体库 合作并跨越大学与基础科学和临床部门的学术任命 医学院艺术与科学学院。教育培训将包括 在亚科学科中的研究和程序化事件的过程，强调AMR的研究和教育 和药物发现或疫苗开发。 ARTDTP将由执行委员会和 由外部咨询委员会和学员完成两年后的双年一次评估 培训计划。从当地和国家 大学和大学将成为ARTDP的优先事项，并将具体的倡议与大学相结合 计划将被用来最大程度地训练URMS。除了训练抗学科 感染性研究ARTDP受训者将接受严格，可重复性的基本概念的教育 以及生物学和生物医学领域的职业所需的伦理。完成培训后 并获得博士学位。学位，ARTDP受训者将准备在术后担任博士后职位 通过培训经验发展其利益的学术界，政府或行业 由我们的T32前计划提供。