Infection and Inflammation as Drivers of Aging (IIDA) Predoctoral Training Program

感染和炎症作为衰老驱动因素 (IIDA) 博士前培训计划

• 批准号: 10179263
• 负责人: Felicia D Goodrum
• 金额: $ 19.7万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10179263
• 关键词: Aging; Infection; Inflammation; Training Programs; pre-doctoral

SUMMARY The most profound demographic change confronting our world is a dramatic increase in individuals over 65 years of age, projected to reach over 80 million people in the US and 1.2 billion worldwide by 2050. The increasing number of older adults has major socioeconomic ramifications. First, the increase in longevity dramatically increases numbers of older adults with multiple chronic diseases and with reduced quality of life. Second, the challenge of managing health care of older adults consumes a disproportionally large segment of health care dollars. Therefore, biomedical innovations must target increasing resilience and healthspan in older adults. Robustly increased training in biomedical sciences pertinent to the biology of aging is critical to address the needs of the growing number of older adults. Here we propose a new, innovative multidisciplinary program designed to train pre-doctoral investigators (4 per year) to define mechanisms underlying the roles of Infection and Inflammation as Drivers of Aging (IIDA). The IIDA training program is comprised of basic scientists, clinicians, and public health mentors at the University of Arizona (UA), a top 20 public Research I University, recognized for its training history in the field of basic biomedical research and for its commitment to mentoring, diversity (designated Hispanic-serving Institution) and cross-disciplinary training. In the last 3 years, as part of unprecedented growth in biomedical sciences, UA has identified research on aging as a pillar of all four strategic initiatives of the UA Health Sciences and as one of top 10 initiatives of the UA College of Medicine. To leverage this, we propose a graduate-level training program with 3 major themes: (i) inflammation and immunity in aging, (ii) persistent infection in aging, and (iii) inflammation and age- related pathology. The 21 NIH-funded faculty supporting this training program have diverse and strong expertise in infection, inflammation, immunology, and age-related pathologies. The training program is supported by a number of UA strengths in aging, basic sciences, clinical practice, and public health. The goal if the IIDA is to harness these strengths towards the premier training program in the underserved area of infection and inflammation as drivers of the aging process. Extensive institutional support, state- of-the-art core facilities, and clinical and public health mentorship will enhance the training experience, that will also have a strong underrepresented minority (URM) outreach and diversity-building component. Thereby, the IIDA training program will provide unique opportunities for training the next generation of diverse scientists to advance our understanding of the biological basis of aging processes and develop strategies to enhance resilience and healthspan.

概括 我们的世界面临的最深刻的人口变化是人口的急剧增加 65 岁以上的个人，预计将覆盖美国超过 8000 万人和 12 亿人 到 2050 年，老年人数量的增加会产生重大的社会经济影响。第一的， 寿命的延长导致患有多种慢性疾病的老年人数量急剧增加 以及生活质量下降。其次，管理老年人医疗保健的挑战 医疗保健费用中的很大一部分。因此，生物医学创新必须瞄准 提高老年人的适应力和健康寿命。大力加强生物医学科学培训 与衰老生物学相关的研究对于满足日益增长的老年人的需求至关重要。 在这里，我们提出了一个新的、创新的多学科项目，旨在培养博士生 研究人员（每年 4 名）将感染和炎症作用的潜在机制定义为 老龄化驱动因素（IIDA）。 IIDA 培训计划由基础科学家、临床医生和公众组成 亚利桑那大学 (UA) 的健康导师是排名前 20 的公立研究型大学，因其 基础生物医学研究领域的培训历史及其对指导、多样性的承诺 （指定西班牙裔服务机构）和跨学科培训。在过去 3 年里，作为 随着生物医学科学空前的发展，UA 已将衰老研究确定为所有四个领域的支柱 UA 健康科学的战略举措，并作为 UA 学院的十大举措之一 药品。为了利用这一点，我们提出了一个包含 3 个主题的研究生培训计划：(i) 衰老过程中的炎症和免疫，（ii）衰老过程中的持续感染，以及（iii）炎症和年龄- 相关病理学。支持该培训计划的 21 名 NIH 资助教师拥有多元化且实力雄厚 感染、炎症、免疫学和年龄相关病理学方面的专业知识。培训计划是 得到了 UA 在老龄化、基础科学、临床实践和公共卫生领域的众多优势的支持。这 如果 IIDA 想要利用这些优势在服务欠缺的地区开展首要培训计划，那么这就是我们的目标 感染和炎症区域是衰老过程的驱动因素。广泛的机构支持，国家 最先进的核心设施以及临床和公共卫生指导将增强培训经验， 它还将具有强大的代表性不足的少数群体 (URM) 外展和多样性建设组成部分。 因此，IIDA 培训计划将为培训下一代提供独特的机会 不同的科学家促进我们对衰老过程的生物学基础的理解并开发 增强复原力和健康寿命的策略。