Adolescent Markers of Depression and the Impact of Alcohol Use

青少年抑郁症的标志和饮酒的影响

• 批准号: 10180803
• 负责人: Alejandro Daniel Meruelo
• 金额: $ 20.41万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10180803
• 关键词: Address; Adolescence; Adolescent; Adolescent and Young Adult; Adult; Affect; Age; Alcohol consumption; Alcohols; Amygdaloid structure; Anisotropy; Anterior; Area; Award; Basal Ganglia; Bilateral; Brain; Brain imaging; Cerebellum; Characteristics; Classification; Classification Scheme; Clinical; Computational Biology; Corpus Callosum; Corpus striatum structure; DSM-V; Data; Depressed mood; Development; Diffusion Magnetic Resonance Imaging; Disease; Early Intervention; Early treatment; Exhibits; Fiber; Fusiform gyrus; Goals; Health; Health system; Heavy Drinking; Hippocampus (Brain); Image; Imaging Techniques; Individual; Inferior; Lead; Left; Life; Linear Regressions; Link; Long-Term Depression; Longitudinal Studies; Magnetic Resonance Imaging; Major Depressive Disorder; Measures; Medial; Mental Depression; Mentored Patient-Oriented Research Career Development Award; Mentorship; Metabolic; Modeling; Monitor; Morbidity - disease rate; National Institute on Alcohol Abuse and Alcoholism; Occipital lobe; Outcome; Participant; Patient Self-Report; Patients; Play; Positioning Attribute; Principal Component Analysis; Process; Quality of life; Reporting; Research; Research Design; Risk; Risk Factors; Role; Running; Sampling; Societies; Stress; Structure; Surface; Symptoms; Teenagers; Testing; Thalamic structure; Thick; Time; Training; Youth; alcohol comorbidity; alcohol use disorder; base; career; career development; child depression; cingulate cortex; clinically significant; comorbid depression; comorbidity; corpus callosum body; cost; depressive symptoms; design; drinking; follow-up; frontal lobe; gray matter; improved; innovation; lateral ventricle; longitudinal analysis; morphometry; mortality; multidisciplinary; neurodevelopment; neuroimaging; recruit; relating to nervous system; responsible research conduct; skill acquisition; statistics; substance use; symptomatology; thalamocortical tract; underage drinking; white matter

PROJECT SUMMARY This K23 award will allow Dr. Meruelo to become an expert on the relationship between adolescent alcohol use and depression. During his training, he proposes to address that untreated alcohol use disorder and depression lead to poor health outcomes ultimately affecting both quality and quantity of life. Dr. Meruelo plans to use an innovative approach and multiple imaging techniques of the NCANDA consortium in a longitudinal study to identify brain features that address the temporal relationship between these two comorbid disorders. Identifying risk factors is of critical importance to anticipating which individuals would benefit from earlier interventions and treatment to reduce morbidity and mortality directly. The award will provide him the support needed to develop expertise in four areas: (1) adolescent alcohol use and major depression, (2) neuroimaging and brain development, (3) advanced statistics, and (4) execution of longitudinal studies. To achieve the K23's goals, Dr. Meruelo has assembled an expert multidisciplinary team. Drs Tapert and Brown will facilitate guidance and access to the activities of and data from a longitudinal study conducted by the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) to address one of NIAAA's major initiatives. They will also provide expertise in adolescent alcohol use and comorbid depression and on planning, recruiting, and implementing longitudinal study designs with adolescents, as well as career and mentorship on the responsible conduct of research. Dr. Schuckit will provide expertise on comorbidity between alcohol and depression and other career development skills. Dr. Thomas will provide hands-on training in advanced longitudinal analyses of associated data. NCANDA data is already available to begin addressing central questions of the proposal. At Year 1 or 2, clinically significant depression has been identified in 61 participants after a healthy prior year following a non- depressed baseline. Also identified are those using moderate or heavy alcohol use at baseline, year 1, and year 2 of the study in 164, 223 and 283 participants, respectively. Year 3 data will be available January 2018. The K23 research specific aims are: (Aim 1) to identify whether any adolescent alcohol use is more likely to lead to long-term depression, or if long-term depression is seen more often after subsequent increases in alcohol use, or both, using latent difference score models to distinguish cause and effect. The common factor of stress and subsequent depression and/or substance use is critical to understanding their impact on growing adolescents, and (Aim 2) to identify morphometrics that predict the development of depression in healthy adolescents using: (a) Naïve Bayesian classifier, and (b) principal component analysis with subsequent hierarchical linear regression.

项目摘要 该K23奖将使Meruelo博士成为青少年之间关系的专家 酒精使用和抑郁。在培训期间，他提议解决未经治疗的酒精使用 疾病和抑郁导致健康状况不佳，最终影响了生活的质量和数量。 Meruelo博士计划使用Ncanda的创新方法和多种成像技术 联盟在一项纵向研究中，以识别解决临时关系的大脑特征 在这两种合并症之间。确定风险因素对于预期至关重要 哪些人将从早期的干预措施和治疗中受益，以降低发病率和死亡率 直接地。该奖项将为他提供在四个领域发展专业知识所需的支持：（1）青少年 酒精使用和重度抑郁症，（2）神经影像学和大脑发育，（3）高级统计和 （4）执行纵向研究。 为了实现K23的目标，Meruelo博士组建了一个专业的多学科团队。 Tapert博士 布朗将促进指导和访问纵向研究的活动和数据 由 青少年（Ncanda）的国家酒精和神经发育联盟 介绍了NIAAA的主要举措之一。他们还将提供青少年饮酒的专业知识和 合并抑郁症以及计划，招募和实施纵向研究设计 青少年，以及负责任的研究行为的职业和心态。 Schuckit Will博士 提供有关酒精与抑郁症与其他职业发展技能合并症的专业知识。 托马斯博士将提供有关相关数据的高级纵向分析的动手培训。 NCANDA数据已经可以开始解决该提案的主要问题。在第1年或2年 在非健康之后，有61名参与者发现了临床意义的抑郁症 抑郁基线。还确定的是在基线，1年级使用中等或大量饮酒的人， 研究分别为164、223和283名参与者。第三年数据将于2018年1月提供。 K23研究的特定目的是：（目标1）确定任何青春期饮酒是否更多 可能导致长期抑郁症，或者在随后的长期抑郁症之后更频繁地看到 使用潜在的差异分数模型来区分因果关系，或两者兼而有之。 压力和随后的抑郁和/或物质使用的共同因素对于 了解他们对成长中的青少年的影响，（目标2）确定预测的形态计量学 使用：（a）幼稚的贝叶斯分类器和（b）校长的健康青少年的抑郁发展 组件分析，随后的分层线性回归。