Adolescent Markers of Depression and the Impact of Alcohol Use

青少年抑郁症的标志和饮酒的影响

基本信息

批准号：
10180803
负责人：
Alejandro Daniel Meruelo
金额：
$ 20.41万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-01 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10180803
关键词：
Address Adolescence Adolescent Adolescent and Young Adult Adult Affect Age Alcohol consumption Alcohols Amygdaloid structure Anisotropy Anterior Area Award Basal Ganglia Bilateral Brain Brain imaging Cerebellum Characteristics Classification Classification Scheme Clinical Computational Biology Corpus Callosum Corpus striatum structure DSM-V Data Depressed mood Development Diffusion Magnetic Resonance Imaging Disease Early Intervention Early treatment Exhibits Fiber Fusiform gyrus Goals Health Health system Heavy Drinking Hippocampus (Brain)Image Imaging Techniques Individual Inferior Lead Left Life Linear Regressions Link Long-Term Depression Longitudinal Studies Magnetic Resonance Imaging Major Depressive Disorder Measures Medial Mental Depression Mentored Patient-Oriented Research Career Development Award Mentorship Metabolic Modeling Monitor Morbidity - disease rate National Institute on Alcohol Abuse and Alcoholism Occipital lobe Outcome Participant Patient Self-Report Patients Play Positioning Attribute Principal Component Analysis Process Quality of life Reporting Research Research Design Risk Risk Factors Role Running Sampling Societies Stress Structure Surface Symptoms Teenagers Testing Thalamic structure Thick Time Training Youth alcohol comorbidity alcohol use disorder base career career development child depression cingulate cortex clinically significant comorbid depression comorbidity corpus callosum body cost depressive symptoms design drinking follow-up frontal lobe gray matter improved innovation lateral ventricle longitudinal analysis morphometry mortality multidisciplinary neurodevelopment neuroimaging recruit relating to nervous system responsible research conduct skill acquisition statistics substance use symptomatology thalamocortical tract underage drinking white matter

项目摘要

PROJECT SUMMARY This K23 award will allow Dr. Meruelo to become an expert on the relationship between adolescent alcohol use and depression. During his training, he proposes to address that untreated alcohol use disorder and depression lead to poor health outcomes ultimately affecting both quality and quantity of life. Dr. Meruelo plans to use an innovative approach and multiple imaging techniques of the NCANDA consortium in a longitudinal study to identify brain features that address the temporal relationship between these two comorbid disorders. Identifying risk factors is of critical importance to anticipating which individuals would benefit from earlier interventions and treatment to reduce morbidity and mortality directly. The award will provide him the support needed to develop expertise in four areas: (1) adolescent alcohol use and major depression, (2) neuroimaging and brain development, (3) advanced statistics, and (4) execution of longitudinal studies. To achieve the K23's goals, Dr. Meruelo has assembled an expert multidisciplinary team. Drs Tapert and Brown will facilitate guidance and access to the activities of and data from a longitudinal study conducted by the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) to address one of NIAAA's major initiatives. They will also provide expertise in adolescent alcohol use and comorbid depression and on planning, recruiting, and implementing longitudinal study designs with adolescents, as well as career and mentorship on the responsible conduct of research. Dr. Schuckit will provide expertise on comorbidity between alcohol and depression and other career development skills. Dr. Thomas will provide hands-on training in advanced longitudinal analyses of associated data. NCANDA data is already available to begin addressing central questions of the proposal. At Year 1 or 2, clinically significant depression has been identified in 61 participants after a healthy prior year following a non- depressed baseline. Also identified are those using moderate or heavy alcohol use at baseline, year 1, and year 2 of the study in 164, 223 and 283 participants, respectively. Year 3 data will be available January 2018. The K23 research specific aims are: (Aim 1) to identify whether any adolescent alcohol use is more likely to lead to long-term depression, or if long-term depression is seen more often after subsequent increases in alcohol use, or both, using latent difference score models to distinguish cause and effect. The common factor of stress and subsequent depression and/or substance use is critical to understanding their impact on growing adolescents, and (Aim 2) to identify morphometrics that predict the development of depression in healthy adolescents using: (a) Naïve Bayesian classifier, and (b) principal component analysis with subsequent hierarchical linear regression.

项目摘要这个K23奖将将Meruelo博士发给他在培训期间提出了饮酒和深度。疾病和抑郁导致池健康结果最终影响Quallity和数量的生命。 Meruelo博士计划使用Ncanda的Ennovative方法和多个成像技术在一项纵向研究中，财团识别以识别解决时间关系的大脑特征在这两种疾病中，确定风险因素至关重要哪些人将从早期的干预措施和治疗中受益，以降低发病率和恶性该奖项将为他提供在四个领域发展专业知识所需的支持：（1）酒精使用和重大抑郁症，（2）神经影像学和大脑发育，（3）高级统计，以及（4）执行纵向研究。为了实现K23的目标，D。Meruelo组成了一支专业的多学科团队。布朗将促进指导并访问纵向研究的活动和数据由你进行青春期酒精和神经发育联盟（NCANDA）谈到NIAAA的主要倡议之一。合并的抑郁症以及计划，招募和隐含纵向研究设计青少年，以及有关研究的响应行为的职业和指导。在酒精与衰落与其他职业发展技能之间提供有关Comorbidge的专业知识。托马斯博士将在对相关数据的高级纵向分析中进行动手训练。 NCANDA数据是可以在第1或2年的中心问题上解决的。在非临床意义的抑郁症已在61名参与者的前一年中患有临床抑郁症抑郁症也确定了那些在基线时使用的中等或大量酒精 164、223和283名参与者的研究将于2018年1月提供敏感。 K23研究的特定目的是：（目标1）确定是否有更多青春期饮酒可能会导致长期抑郁症，或者如果看到长期深度随后发生更多使用潜在的差异分数模型来区分因果关系，或两者兼而有之。压力和随后的深度和/或物质使用的共同因素对于了解对成长中青少年的影响，（目标2）确定预测的形态计量学使用：（a）幼稚的贝叶斯分类器和（b）校长的健康青少年剥夺的发展组件分析，随后的分层线性回归。