Research-Dedicated Magnetic Resonance Imaging at McGuire VA Medical Center

麦奎尔退伍军人医疗中心的研究专用磁共振成像

• 批准号: 10177717
• 负责人: Jose Francisco Huizar
• 金额: --
• 依托单位: VA VETERANS ADMINISTRATION HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-10-01 至 2021-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10177717
• 关键词: Address; Alzheimer' s Disease; Anatomy; Anxiety; Appearance; Applications Grants; Area; Back; Basic Science; Biomedical Engineering; Body Composition; Breast; COVID-19; Cardiac; Cardiology; Cardiomyopathies; Cardiotoxicity; Caring; Childhood; Claustrophobias; Clinical; Clinical Research; Collaborations; Conflict (Psychology); Coronary; Data; Diagnostic; Diffusion Magnetic Resonance Imaging; Discipline; Ectopic beats; Elements; Ensure; Equipment; Evaluation; Exercise; Exercise Test; Fatty acid glycerol esters; Fees; Functional Magnetic Resonance Imaging; Funding; Generations; Gold; Head; Health Care Research; Heart Diseases; Heart failure; Helium; Hepatology; Human Resources; Image; Imaging technology; Infrastructure; Institution; Institutional Review Boards; International; Length; Link; Liver; Liver diseases; Logistics; MRI Scans; Magnetic Resonance; Magnetic Resonance Imaging; Medical; Medical center; Mental Depression; Mental Health; Minor; Multiple Sclerosis; Neurology; Noise; Oncology; Optics; Organ; Orthopedics; Outsourcing; Pain management; Parkinson Disease; Patients; Performance; Physicians; Post-Traumatic Stress Disorders; Property; Protocols documentation; Psychiatry; Radiology Specialty; Rehabilitation therapy; Research; Research Activity; Research Institute; Research Personnel; Scanning; Scientist; Signal Transduction; Speed; Spinal; Spinal cord injury; Spinal cord injury patients; Structure; Substance abuse problem; System; Technology; Technology Transfer; Tissues; Toes; Traumatic Brain Injury; Travel; Uncertainty; Ventricular Function; Veterans; Wait Time; Walkers; Water; biomedical referral center; chemotherapy; clinical care; conflict resolution; density; design; diagnosis standard; experience; heart imaging; high resolution imaging; improved; medical specialties; myocardial injury; neurosurgery; operation; participant enrollment; pressure; research study; sound; tool; Address; Alzheimer' s Disease; Anatomy; Anxiety; Appearance; Applications Grants; Area; Back; Basic Science; Biomedical Engineering; Body Composition; Breast; COVID-19; Cardiac; Cardiology; Cardiomyopathies; Cardiotoxicity; Caring; Childhood; Claustrophobias; Clinical; Clinical Research; Collaborations; Conflict (Psychology); Coronary; Data; Diagnostic; Diffusion Magnetic Resonance Imaging; Discipline; Ectopic beats; Elements; Ensure; Equipment; Evaluation; Exercise; Exercise Test; Fatty acid glycerol esters; Fees; Functional Magnetic Resonance Imaging; Funding; Generations; Gold; Head; Health Care Research; Heart Diseases; Heart failure; Helium; Hepatology; Human Resources; Image; Imaging technology; Infrastructure; Institution; Institutional Review Boards; International; Length; Link; Liver; Liver diseases; Logistics; MRI Scans; Magnetic Resonance; Magnetic Resonance Imaging; Medical; Medical center; Mental Depression; Mental Health; Minor; Multiple Sclerosis; Neurology; Noise; Oncology; Optics; Organ; Orthopedics; Outsourcing; Pain management; Parkinson Disease; Patients; Performance; Physicians; Post-Traumatic Stress Disorders; Property; Protocols documentation; Psychiatry; Radiology Specialty; Rehabilitation therapy; Research; Research Activity; Research Institute; Research Personnel; Scanning; Scientist; Signal Transduction; Speed; Spinal; Spinal cord injury; Spinal cord injury patients; Structure; Substance abuse problem; System; Technology; Technology Transfer; Tissues; Toes; Traumatic Brain Injury; Travel; Uncertainty; Ventricular Function; Veterans; Wait Time; Walkers; Water; biomedical referral center; chemotherapy; clinical care; conflict resolution; density; design; diagnosis standard; experience; heart imaging; high resolution imaging; improved; medical specialties; myocardial injury; neurosurgery; operation; participant enrollment; pressure; research study; sound; tool

PROJECT SUMMARY / ABSTRACT Advances in Magnetic Resonance Imaging (MRI) have become astonishing in the medical field, allowing the assessment of structural and tissue characterization of many organs and functional features of some. Thus, MRI has become a critical tool for clinical and research use in multiple disciplines including neurology, neurosurgery, psychiatry, oncology, pain management, rehabilitation, and cardiology to mention few. The limited availability of the current MRI scanners for research at the McGuire VAMC frequently results in outsourcing MRI scans to other institutions and further IRB approval for researchers, besides limiting patient enrollment and adding wait times, logistical and travel burden to our Veterans participating in research. Furthermore, the lack of an MRI scanner limits collaborations with other institutions and clinical research consortiums in multiple areas including traumatic brain injury (TBI), spinal cord injury (SCI), PTSD, Alzheimer’s and Parkinson’s disease, multiple sclerosis, liver and cardiac disease. We request the funds to acquire a 3 Tesla Magnetic Resonance Imaging (3T-MRI) designed to provide versatility to meet the increasing demands in clinical research. Its current features offer a comprehensive application portfolio with unique functions, as well as a short and open appearance to reduce patient anxiety and claustrophobia. The equipment will have multiple advanced clinical and scientific suites for research applications in multiple disciplines such as tissue characterization, Diffusion Tensor Imaging (DTI) and functional MRI (fMRI). The requested 3T-MRI will provide accessibility of all required MRI features to all our 9 major and 6 minor users. This will allow Drs. Fuchs and Pandak to perform required magnetic resonance enterography (MRE) and liver fat content; Drs. Hundley and Huizar to complete and expand their studies in heart failure and cardiomyopathy associated with ectopic beats, myocardial injury in COVID-19, cardiotoxicity, and MRI exercise testing after chemotherapy; Dr Walker (LIMIBIC consortium) and Dr. McDonald (MIRECC and ENIGMA-PTSD consortium) to perform advanced MRI with DTI and fMRI to study TBI and PTSD; Dr. Gorgey to assess body composition, adaptation of tracts to trans-spinal / epidural stimulation and exercise using DTI in SCI patients; Dr. Bjork to study mental health, depression, and substance abuse with fMRI; and Dr. Gitchel to expand his current efforts with Parkinson’s disease research (PADRECC). The McGuire VAMC has a tradition for excellence in clinical care as a tertiary referral center with 3 current state-of-the-art scanners, primarily for clinical use. Thus, the infrastructure and expertise to install, maintain and sustain the 3T MRI scanner are in place. Similarly, the McGuire VAMC has had a long tradition of basic and clinical research funding for at least 30 years supporting multiple research protocols and investigators. This application is fully supported by all our VA officials including the Medical Center Director, Chief of Staff, Chief of Bioengineering, Research Department and Radiology, providing the full infrastructure, physical space, human resources and financial commitment to install, maintain and sustain this equipment. An detailed sustainment plan with a back-fee structure and an organizational plan with an oversight mechanism and conflict resolution is in place to assure its fair use and avoid conflicts. Thus, a research-dedicated MRI scanner is feasible and will address our current limitations and allow all investigators within McGuire VAMC and other neighboring institutions to add comprehensive structural and functional assessment in their respective disciplines using state-of-the-art MRI technology. This new MRI infrastructure, if funded, is likely to change the research trajectory for multiple specialties at the McGuire VAMC and likely will attract physician scientists and researchers to join our VAMC. Most importantly, it will open new opportunities for multiple investigators to participate / collaborate in national and international research studies and consortiums.

项目摘要 /摘要 磁共振成像的进步（MRI）在医学领域变得惊人，允许 评估许多器官的结构和组织表征以及某些人的功能特征。那， MRI已成为多个学科的临床和研究使用的关键工具，包括神经病学， 神经外科，精神病学，肿瘤学，疼痛管理，康复和心脏病学很少有人提及。 经常在McGuire VAMC进行研究的当前MRI扫描仪的可用性有限 导致将MRI扫描外包给其他机构，并向研究人员提供进一步的IRB批准 限制患者入学率并增加等待时间，后勤和旅行伯恩（Burnen）到我们的退伍军人 参与研究。此外，缺乏MRI扫描仪限制与其他合作 在包括创伤性脑损伤（TBI），脊柱的多个地区的机构和临床研究联盟 绳索损伤（SCI），PTSD，阿尔茨海默氏病和帕金森氏病，多发性硬化症，肝脏和心脏病。 我们要求资金购买3个特斯拉磁共振成像（3T-MRI）旨在提供 多功能性满足临床研究中日益增长的需求。其当前功能提供了全面的 具有独特功能的应用程序组合，以及简短而开放的外观，以减少患者动画和 幽闭恐惧症。该设备将有多个用于研究应用的高级临床和科学套件 在多个学科中，例如组织表征，扩散张量成像（DTI）和功能性MRI（fMRI）。 所请求的3T-MRI将为我们所有9大专业和6个所需的MRI功能提供所有必需的MRI功能 次要用户。这将允许Drs。 Fuchs和Pandak进行所需的磁共振娱乐 （MRE）和肝脂肪含量；博士。 Hundley和Huizar完成和扩大他们在心力衰竭和 与生态节拍相关的心肌病，COVID-19中的心肌损伤，心脏毒性和MRI运动 化学疗法后的测试； Walker博士（Limibic Consortium）和McDonald博士（Mirecc和Enigma-Ptsd 联盟）用DTI和fMRI进行高级MRI，以研究TBI和PTSD；华丽博士评估身体 组成，在SCI患者中使用DTI对跨性脊髓 /硬膜外刺激的适应和运动；博士 Bjork通过fMRI研究心理健康，抑郁和药物滥用；吉切尔博士扩大了他的当前 帕金森氏病研究（PADRECC）的努力。 McGuire VAMC的传统是临床护理的良好传统，作为第三次转诊中心，有3个电流 最先进的扫描仪，主要用于临床。那就是安装，维护和 维持3T MRI扫描仪已就位。同样，McGuire VAMC具有悠久的基本传统和 至少30年来支持多个研究方案和研究人员。 该申请得到了我们所有VA官员的全面支持，包括医疗中心主任，负责人 工作人员，生物工程部长，研究部和放射学，提供完整的基础设施，物理 空间，人力资源和财务承诺，以安装，维护和维护此设备。详细 维持背景结构和具有监督机制和冲突的组织计划 解决方案是为了合理使用并避免冲突。那是一个研究的MRI扫描仪是 可行，并将解决我们目前的局限性，并允许McGuire VAMC和其他调查人员 邻近的机构在其各自的 使用最先进的MRI技术的学科。这个新的MRI基础设施（如果资助）可能会改变 McGuire VAMC多个专业的研究轨迹，可能会吸引医生 科学家和研究人员加入我们的VAMC。最重要的是，它将为多重 研究人员参加 /合作参加国际和国际研究和财团。