An Eiger2 XE 9M detector for the NYSBC-operated NYX beamline at NSLS-II

用于 NSLS-II NYSBC 操作的 NYX 光束线的 Eiger2 XE 9M 探测器

• 批准号: 10176813
• 负责人: KEVIN P BATTAILE
• 金额: $ 179.47万
• 依托单位: NEW YORK STRUCTURAL BIOLOGY CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10176813
• 关键词: Area; Communities; Crystallography; Data Collection; Funding; Institution; Laboratories; Light; Methods; Modernization; New York; Photons; Radiation induced damage; Research; Roentgen Rays; Sampling; Services; Source; Speed; Structural Biologist; Synchrotrons; System; Time; United States National Institutes of Health; beamline; data quality; detector; expectation; member; programs; prototype; structural biology

Project Summary The New York Structural Biology Center (NYSBC) owns and operates the NYX beamline at the National Synchrotron Light Source II (NSLS-II) which is located at the Brookhaven National Laboratory (BNL) and operated for the benefit of the member institutions of the NYSBC and the community of non-consortium-member structural biologists. We seek funds to acquire a Dectris Eiger2 XE 9M X-ray detector for macromolecular crystallography. This advanced, high-speed readout of the detector will significantly increase the throughput of samples and therefore increase the number of projects that can be prosecuted in a set amount of time. The high frame rate will allow us to perform advanced crystallographic methods that are not possible with our current experimental setup, such as serial crystallography, ultra-fast rastering and potentially outrunning radiation damage during data collection. NYX has been operating with a prototype pixel array detector from Area Detector Systems Corporation (HF-4M) since its inception at NSLS-II. While the data quality from this detector has been comparable with other available detectors, ADSC ceased to operate several years ago with the result that the detector is no longer serviceable and is starting to fail. In order to remain valuable to users, it is imperative that we replace the ADSC HF-4M with a modern pixel array detector with the expectation that it will remain useful and serviceable for the next 8-10 years. Of particular importance is performing this upgrade prior to the temporary shutdown of the Advanced Photon Source for a facility upgrade in 2022 when the demand for synchrotron access for NIH-funded projects is expected to increase dramatically. Having this detector in place in 2021 will allow NYX to significantly enhance the NIH-funded research programs of the NYSBC consortium members, non- consortium members as well as be fully prepared to provide uninterrupted access to NIH-funded projects due to the temporary closure of the APS.

项目摘要 纽约结构生物学中心（NYSBC）拥有并运营NYX Beamine 位于Brookhaven的National Synchrotron Light Source II（NSLS-II） 国家实验室（BNL），并为成员机构的利益运营 NYSBC和非符合人群的结构生物学家社区。我们寻找 获得eiger2 XE Dectris eiger2 9M X射线检测器的资金用于大分子 晶体学。该检测器的高级高速读数将显着 增加样本的吞吐量，因此增加了可以 在一定的时间内起诉。高帧速率将使我们能够执行 我们当前的实验是不可能的高级晶体学方法 设置，例如串行晶体学，超快速的栅格和潜在的超越 数据收集期间的辐射损坏。 NYX一直使用原型像素运行 自从其成立以来，来自地区探测器系统公司（HF-4M） NSLS-II。虽然该检测器的数据质量与其他 可用探测器，ADSC几年前停止运行，结果 检测器不再有用，并且开始失败。为了保持有价值 用户，我们必须用现代像素阵列替换ADSC HF-4M 探测器期望它将在接下来的8-10中保持有用且可服务 年。特别重要的是在临时之前执行此升级 关闭2022年设施升级的高级光子源 NIH资助项目对同步加速器访问的需求有望增加 急剧。在2021年将该检测器设置在适当的位置将使NYX显着 增强NYSBC财团成员的NIH资助研究计划，非 - 财团会员以及充分准备，以提供不间断的访问权限 NIH资助的项目由于AP的暂时关闭。