Epidemiology of SARS-CoV-2 in Low-income Countries.

低收入国家 SARS-CoV-2 的流行病学。

• 批准号: 10188735
• 负责人: Michael Stephen Glickman
• 金额: $ 63.29万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10188735
• 关键词: 2019-nCoV; Acquired Immunodeficiency Syndrome; Address; Adult; African; Antibodies; Area; Arrhythmia; Autopsy; COVID-19; COVID-19 pandemic; Cardiac; Caring; Cellular Phone; Cessation of life; Chronic lung disease; Clinical; Clinical Trials; Cohort Analysis; Collaborations; Communication; Communities; Conduct Clinical Trials; Country; Data; Development; Disease; Echocardiography; Electrocardiogram; Emergency Situation; Enrollment; Epidemic; Epidemiology; Functional disorder; Funding; Future; Geography; Goals; HIV; HIV Infections; HIV/TB; Haiti; Haitian; Health; Heart Diseases; Heart Injuries; Home environment; Hospital Records; Hypertension; Immunoglobulin G; Incidence; Income; Infection; Infrastructure; Intervention Trial; Left; Left Ventricular Function; Low income; Motion; Myocardial Ischemia; Myocarditis; National Institute of Allergy and Infectious Disease; Natural History; Outcome; Participant; Patients; Population; Positioning Attribute; Prevalence; Prevention; Preventive Intervention; Procedures; Protocols documentation; Pulmonary Hypertension; Pulmonary Tuberculosis; Report (document); Reporting; Research; Research Infrastructure; Risk; Risk Factors; Seminal; Serologic tests; Severities; Survivors; Symptoms; Tanzania; Telephone; Telephone Interviews; Troponin; United States National Institutes of Health; Universities; Ventricular; Viral Respiratory Tract Infection; Virus Diseases; Visit; World Health Organization; cohort; falls; follow-up; heart function; improved; infection rate; low income country; mortality; pandemic disease; public health intervention; symptomatology

The COVID-19 pandemic has now spread from high- and middle-income countries to low-income countries, including Haiti and Tanzania. The natural history of COVID-19 is unknown in low-income countries. We propose to study a combined cohort of 3,054 adults in Haiti and Tanzania to determine the attack rate of SARS-CoV-2 infection and severe COVID-19, to examine interactions with HIV infection, pulmonary tuberculosis, and hypertension in populations of African descent, and to determine long term cardiac complications of COVID-19. Cornell University has collaborated with the Groupe Haitien d’Etude du Sarcome de Kaposi et des Infections Opportunistes (GHESKIO) in Haiti for 38 years and for 15 years with the Mwanza Intervention Trials Unit (MITU) in Tanzania. The proposed emergency supplement leverages these collaborations and four established NIH-supported cohorts, which have already been enrolled, to address NIAID priority areas. The specific aims are: 1.To determine the incidence proportion of SARS-CoV-2 infection and the attack rate and risk factors for severe COVID-19, in well characterized cohorts of 3,054 adults from low-income communities in Haiti and Tanzania. Starting May 1, 2020 we will conduct monthly telephone interviews with the 3,054 participants who are in active follow-up to record symptoms of COVID-19 during the pandemic. Participants will also be encouraged to telephone us if they develop new symptoms. We have cell phone numbers for all cohort participants and have established procedures for telephone communication. We will also review hospital records, perform verbal autopsies, and grade severity of COVID-19. We have banked sera from all participants collected in 2016-2019. In September-November 2020 and again in March-May 2021, we will collect follow-up sera and perform serologic testing for the presence of anti-SARS-CoV-2 IgG antibodies. We will determine the odds for development of severe COVID-19 in participants who had HIV, TB, and hypertension. 2. To determine the cardiac complications of SARS-CoV-2 infection in 1,909 adults with known baseline cardiac function. In 1,909 patients who previously had baseline EKGs and echocardiograms (2016-2019), we will repeat cardiac echo and EKG in 2021 to quantify the odds for development of incident left ventricular systolic dysfunction in those who did and did not become SARS-CoV-2 infected. LV function will be quantified by global longitudinal strain. We will also determine incidence of right ventricular systolic dysfunction, pulmonary hypertension and segmental wall motion abnormalities by echocardiogram, and new Q-waves and other abnormalities on EKG. Defining viral infection rates and natural history in low-income countries will be critical for future prevention interventions. Determining risk for people with HIV, TB, and hypertension will improve their care and prevention. Understanding cardiac sequelae of SARS-CoV-2 will improve care for COVID-19 survivors.

Covid-19-19现在已经从高收入国家和低收入国家传播到低收入国家， 包括海地和坦桑尼亚。在低收入国家，Covid-19的自然历史尚不清楚。我们 提议研究海地和坦桑尼亚的3,054名成年人组合的联合队列以确定的攻击率 SARS-COV-2感染和严重的Covid-19，以检查与HIV感染，肺部的相互作用 结核病和非洲血统种群的高血压，并确定长期心脏 COVID-19的并发症。康奈尔大学与海地d'Etude du Sarcome合作 海地的Kaposi et des感染机会主义者（Gheskio）持续了38年，持续了15年 坦桑尼亚的干预试验单位（MITU）。拟议的紧急补充剂利用这些 合作和四个已签署的NIH支持的同类人才已被录取，以解决 NIAID优先区域。具体目的是： 1.确定SARS-COV-2感染的事件比例以及攻击率和风险因素 对于严重的Covid-19。 海地和坦桑尼亚。从2020年5月1日开始，我们将每月与3,054进行电话采访 正在积极随访的参与者记录大流行期间Covid-19的症状。参与者会 我们有所有的手机号码 队列参与者，并建立了电话通信的程序。我们还将审查医院 记录，进行言语尸检和COVID-19的年级严重程度。我们已经从所有参与者那里存放了血清 收集于2016 - 2019年。在2020年9月至11月，再次在2021年3月3日，我们将收集随访 血清并进行血清学测试，以实现抗SARS-COV-2 IgG抗体的存在。我们将确定 患有艾滋病毒，结核病和高血压的参与者的严重共同证明的赔率。 2。确定1,909名具有已知基线的成年人SARS-COV-2感染的心脏并发症 心脏功能。在1,909例以前具有基线心电图和超声心动图的患者中（2016-2019），我们 将在2021年重复心脏回声和心电图，以量化事件发展的几率 在那些并且没有被SARS-COV-2感染的人中的收缩功能障碍。 LV功能将被量化 由全球纵向应变。我们还将确定右心室收缩功能障碍的事件， 超声心动图以及新的Q波和新的Q波的肺高血压和节段性壁运动异常 心电图的其他异常。 在低收入国家定义病毒感染率和自然历史对于将来的预防至关重要 干预措施。确定艾滋病毒，结核病和高血压患者的风险将改善他们的护理和 预防。了解SARS-COV-2的心脏后遗症将改善对Covid-19的生存的护理。

项目成果

Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome.

• DOI: 10.1021/acsinfecdis.6b00172
• 发表时间: 2017-02-10
• 期刊: ACS infectious diseases
• 影响因子: 5.3
• 作者: Totaro KA;Barthelme D;Simpson PT;Jiang X;Lin G;Nathan CF;Sauer RT;Sello JK
• 通讯作者: Sello JK

Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma.

C-2取代对非传统头孢菌素在小鼠血浆中稳定性的影响。

• DOI: 10.1038/s41429-019-0167-y
• 发表时间: 2019
• 期刊: The Journal of antibiotics
• 作者: Zimmerman,Matthew;McDonald,StaceyL;Ho-Liang,Hsin-Pin;Porubsky,Patrick;Nguyen,Quyen;Pharr,CameronW;Perkowski,AndrewJ;Smith,Robert;Schoenen,FrankJ;Gold,BenS;Zhang,David;Nathan,CarlF;Dartois,Véronique;Aubé,Jeffrey
• 通讯作者: Aubé,Jeffrey

Rapid Emergence and Spread of Severe Acute Respiratory Syndrome Coronavirus 2 Gamma (P.1) Variant in Haiti.

• DOI: 10.1093/cid/ciab736
• 发表时间: 2022-06-10
• 期刊: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
• 作者: Tagliamonte MS;Mavian C;Zainabadi K;Cash MN;Lednicky JA;Magalis BR;Riva A;Deschamps MM;Liautaud B;Rouzier V;Fitzgerald DW;Pape JW;Morris JG;Salemi M
• 通讯作者: Salemi M

Targeting protein biotinylation enhances tuberculosis chemotherapy.

• DOI: 10.1126/scitranslmed.aal1803
• 发表时间: 2018-04-25
• 期刊: Science translational medicine
• 影响因子: 17.1
• 作者: Tiwari D;Park SW;Essawy MM;Dawadi S;Mason A;Nandakumar M;Zimmerman M;Mina M;Ho HP;Engelhart CA;Ioerger T;Sacchettini JC;Rhee K;Ehrt S;Aldrich CC;Dartois V;Schnappinger D
• 通讯作者: Schnappinger D

Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection.

• DOI: 10.1038/s41467-021-26941-1
• 发表时间: 2021-11-15
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Beites T;Jansen RS;Wang R;Jinich A;Rhee KY;Schnappinger D;Ehrt S
• 通讯作者: Ehrt S